导师姓名： 黄倩 专业代码： 100214
性别： 女 专业名称： 肿瘤学
培养单位： 附属第一人民医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师： 兼
联系方式： qianh2011@126.com
邮编： 邮箱地址： qhuang@sjtu.edu.cn

研究方向 (点击浏览详细信息)
肿瘤发生与复发机制研究

社会任职
《中华医学会上海分会肿瘤靶分子专业委员会》委员
《中国生物技术协会基因治疗分会》常委
《中国医药生物技术协会精准医疗分会》 常委
《上海细胞治疗工程技术研究中心》理事

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 放疗诱导的多核巨细胞去多倍体化导致肿瘤再增殖机制研究 国家自然科学基金 2020-01~2023-12 60万元 课题负责人
** 放疗后细胞坏死与HMGB1释放与肿瘤再增殖的关系 国家自然基金委 2016-01~2019-12 57万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Jin Cheng, Sijia He, Min Wang, Ling Zhou, Zhengxiang Zhang, Xiao Feng,Yang Yu, JingjingMa,Chenyun Dai, Shengping Zhang, Lianhui Sun,Yanping Gong,YiweiWang, Minghui Zhao,Yuntao Luo, Xinjian Liu, Ling Tian, Chuanyuan Li, and Qian Huang （通讯作者） The Caspase-3/PKCd/Akt/VEGF-A Signaling Pathway Mediates Tumor Repopulation during Radiotherapy Clin Cancer Res 2019 25(12): 3732-43
Sijia He, Jin Cheng, Lianhui Sun, Yiwei Wang, Chuangui Wang, Xinjian Liu, Zhengxiang Zhang, Minghui Zhao, Yuntao Luo, Ling Tian, Chuanyuan Li and Qian Huang HMGB1 released by irradiated tumor cells promotes living tumor cell proliferation via paracrine effect Cell Death and Disease 2018 9:648
Xiao Feng, Yang Yu, Sijia He, Jin Cheng, Yanping Gong, Zhengxiang Zhang, Xuguang Yang, Bing Xu, Xinjian Liu, Chuan-Yuan Li, Ling Tian, Qian Huang （通讯作者） Dying glioma cells establish a proangiogenic microenvironment through a caspase 3 dependent mechanism. Cancer Letters. 2017 385:12-20
Yang Yu, Ling Tian, Xiao Feng, Jin Cheng, Yanping Gong, Xianjian Liu, Zhengxiang Zhang, Xuguang Yang, Sijia He, Chuanyuan Li, Qian Huang. （通讯作者） eIF4E-phosphorylation-mediated Sox2 upregulation promotes pancreatic tumor cell repopulation after irradiation Cancer Letters 2016 375(1):31-38.
Jin Cheng, Ling Tian, Jingjing Ma, Yanping Gong, Zhengxiang Zhang, Zhiwei Chen, Bing Xu, Hui Xiong, Chuanyuan Li, Qian Huang. Dying tumor cells stimulate proliferation of living tumor cells via caspase-dependent protein kinase Cδ activation in pancreatic ductal adenocarcinoma Mol Oncol. 2015 doi: 10.1016/j.molonc.2014.07.024
Xiao Feng, Ling Tian, Zhengxiang Zhang, Yang Yu, Jin Cheng, Yanping Gong, Chuan-Yuan Li and Qian Huang. Caspase 3 in dying tumor cells mediates post-irradiation angiogenesis. Oncotarget. 2015 6(32):32353-32367
Zhengxiang Zhang, Min Wang, Ling Zhou, Xiao Feng, Jin Cheng, Yang Yu1, Yangping Gong, Yin Zhu, Chuanyuan Li, Ling Tian, Qian Huang. Increased HMGB1 and cleaved caspase3 stimulate tumor repopulation and is correlated to poor prognosis in colorectal cancer. Journal of Experimental & Clinical Cancer Research. 2015 DOI 10.1186/s13046-015-0166-1
Jingjing Ma, Jin Cheng, Yanping Gong, Ling Tian, Qian Huang Wnt signaling downregulated after sonic hedgehog activation negatively associates with tumor repopulation Disease Model & Mechanism 2015 9:105-114.
Ming Quan, Jiujie Cui, Tian Xia,Zhiliang Jia, Dacheng Xie, Daoyan Wei, Suyun Huang, Qian Huang （通讯作者）, Shaojiang Zheng, and Keping Xie. Merlin/NF2 Suppresses Pancreatic Tumor Growth and Metastasis by Attenuating the FOXM1-Mediated Wnt/beta-catenin Signaling Cancer Res 2015 75（22）:4778-89
Fang Wei, Huiping Wang, Xiafang Chen, Chuanyuan Li , Qian Huang. Dissecting the roles of E1A and E1B in adenoviral replication and RCAd-enhanced RDAd transduction efficacy on tumor cells Cancer Biology & Therapy 2014 doi: 10.4161/cbt.29842
Donato AL, Huang Q （共同第一作者）, Liu X, Li F, Zimmerman MA, Li CY. Caspase 3 Promotes Surviving Melanoma Tumor Cell Growth after Cytotoxic Therapy J Invest Dermatol. 2014 2014 Jan 16. doi: 10.1038/jid.2014.18.
Zhou L, Li K, Luo Y, Tian L, Wang M, Li C, Huang Q. Novel prognostic markers for patients with triple-negative breast cancer Hum Pathol. 2013 44(10):2180-7
Wei F, Wang H, Zhang J, Chen X, Li C, Huang Q Pharmacokinetics of combined gene therapy expressing constitutive human GM-CSF and hyperthermia-regulated human IL-12 J Exp Clin Cancer Res 2013 32：5
Ling Zhou, Yanli Luo, Ke Li, Ling Tian, Min Wang, Chuanyuan Li, Qian Huang Molecular markers for predicting therapeutic resistance in breast cancer Hum Pathol 2013 44(7):1421-8
Ma J, Tian L, Cheng J, Chen Z, Xu B, Wang L, Li C, Huang Q Sonic hedgehog signaling pathway supports cancer cell growth during cancer radiotherapy PLoS One 2013 2013 Jun 10;8(6):e65032. doi: 10.1371/journal.pone.**
Luo Y, Tian L, Feng Y, Yi M, Chen X, Huang Q. The Predictive Role of p16 Deletion, p53 Deletion, and Polysomy 9 and 17 in Pancreatic Ductal Adenocarcinoma Pathol Oncol Res. 2013 19(1):35-40
Luo Y, Qiu Z, Tian L, Zhu G, Feng Y, Yi M, Chen X, Wang L, Li C, Huang Q. Identification of novel predictive markers for the prognosis of pancreatic ductal adenocarcinoma Hum Pathol. 2013 44(1):69-76
Wang H, Wei F, Zhang J, Wang F, Li H, Chen X, Xie K, Wang Y, Li C, Huang Q A novel immunocompetent murine tumor model for the evaluation of RCAd-enhanced RDAd transduction efficacy Tumour Biol. 2012 33(4):1245-53
Ye Feng,Wengjing Bao,Yanli Luo,Ling Tian,Xiafang Chen,Miaoying Yi,Hui Xiong,Qian Huang Phosphomimetic Mutants of Pigment Epithelium-Derived Factor with Enhanced Anti-Choroidal Melanoma Cell Activity In Vitro and In Vivo. IOVS 2012 10(53):6793-6802
Zhang S, Wu J, Wu X, Xu P, Tian Y, Yi M, Liu X, Dong X, Wolf F, Li C, Huang Q. Enhancement of rAAV2-Mediated Transgene Expression in Retina Cells In Vitro and In Vivo by Coadministration of Low-Dose Chemotherapeutic Drugs Invest Ophthalmol Vis Sci. 2012 53(6):2675-84
Huang Q （共同第一作者）, Li F, Liu XJ, Li WR, He ZM, Peng YL, Shen JP, Wolf F, Han GW, Wang XJ, Thorburn A, Bedford J, Li CY. Caspase-mediated stimulation of tumor cell repopulation during Cancer Radiotherapy Nature Medicine 2011 17:860-867
Liu XJ, Qian QJ, Xu P, Wolf F, Zhang JF, Zhang DB, Li CY, Huang Q. A Novel Conditionally Replicating ‘‘Armed’’ Adenovirus Selectively Targeting Gastrointestinal Tumors with Aberrant wnt Signaling Human Gene Therapy 2011 71:4130-4137
Xinjian Liu, Jinjun Li, Yuhua Tian, Ping Xu, Xiafang Chen, Kuangchen Xie, Zhengjun Qiu, Yufei Wang, Dabing Zhang, Frank Wolf, Chuanyuan Li, and Qian Huang. Enhanced Pancreatic Cancer Gene Therapy by Combination of Adenoviral Vector Expressing c-erb-B2 (Her-2/neu)-Targeted Immunotoxin with a Replication-Competent Adenovirus or Etoposide. Human Gene Therapy 2010 21:157-170
Xunda Ji , Lin Cheng, Fang Wei, Huiming Li, Mengyun Wang, Yuhua Tian, Xiafang Chen, Yufei Wang, Frank Wolf, Chuanyuan Li, Qian Huang. Non-invasive Visualization of Retinoblastoma Growth and Metastasis via Bioluminescence Imaging. Invest Ophthalmol Vis Sci 2009 50:5544-5551
Xunda Ji , Lin Cheng, Fang Wei, Huiming Li, Mengyun Wang, Yuhua Tian, Xunda Ji, Jufeng Zhang, Lin Cheng, Fang Wei, Huiming Li, Xinjian Liu, Xiafang Chen, Chuanyuan Li, Yufei Wang, Qian Huang. Oncolytic adenovirus delivering herpes simplex virus thymidine kinase suicide gene reduces the growth of human retinoblastoma in an in vivo mouse model Exp Eye Res. 2009 89:193-199
Liu X, Wu J, Zhang S, Li C, Huang Q. Novel strategies to augment genetically delivered immunotoxin molecular therapy for cancer therapy Cancer Gene Ther 2009 16:861-868
Jihong Wu, Shenghai Zhang, Xiaobing Wu, Xiaoyan Dong, Ping Xu, Xinjian Liu, Chuanyuan Li, Qian HuangZhang, Lin Cheng, Fang Wei, Huiming Li, Xinjian Liu, Xiafang Chen, Chuanyuan Li, Yufei Wang, Qian Huang. Enhanced transduction and improved photoreceptor survival of retinal degeneration by the combinatorial use of rAAV2 with a lower dose of adenovirus Vision Research 2008 48:1648–1654
Shenghai Zhang, Jihong Wu, Xiaobing Wu, Xiaoyan Dong, Xinjian Liu, Chuanyuan Li, Qian Huang Distinctive gene transduction efficiencies of commonly used viral vectors in the retina. Curr Eye Res 2008 33:81-90
Jufeng Zhang, Zhanli Wang, Fang Wei, Wei Qiu, Liangren Zhang, Qian Huang. Computational modeling and functional analysis of Herpes simplex virus type-1 thymidine kinase and Escherichia coli cytosine deaminase fusion protein. Biochem Biophys Res Commun 2007 361:946-952
Hui Yu, Jihong Wu, Huiming Li, Zhanli Wang, Xiafang Chen, Yuhua Tian, Miaoying Yi, Xunda Ji, Jialie Ma, Qian Huang. nhibition of corneal neovascularization by recombinant adenovirus mediated sFlk-1 expression Biochem Biophys Res Commun 2007 360:46-50
Qian Huang, XiuWu Zhang, He Wang, Bin Yan, Mark W. Dewhirst, and ChuanYuan Li A novel conditionally replicative adenovirus vector targeting telomerase-positive tumor cells Clinical Cancer Research 2004 10:1439-1445
Chuan-yuan Li, Siqing Shan, Qian Huang （共同第一作者）, Rod Brun, Jeniffer Lanzen, Kang Hu, Pengnian Lin, and Mark W. Dewhirst Initial stages of tumor cell-induced angiogenesis: Evaluation via skin window chambers in rodent models. Journal of the National Cancer Institute 2000 92:143-147.
Qian Huang, Jim K.Hu, Frank Lohr, Li Zhang, Rod Brun, Jeniffer Lanzen, John B. Little, Mark W. Dewhirst and Chuan-yuan Li Heat-induced gene expression as a novel targeted cancer gene therapy strategy Cancer Research 2000 60:3435-3439
Qian Huang （共同第一作者）, Siqing Shan, Rod D. Braun, Jennifer Lanzen, Gopal Anyrhambatla, Garheng Kong, Michael Borelli, Peter Corry, Mark W. Dewhirst, and Chuan-yuan Li. Noninvasive visualization of tumors in radent dorsal skin window chambers. Nature Biotechnology 1999 17:1033-1035