导师姓名： 洪江 专业代码： 100218
性别： 男 专业名称： 急诊医学
培养单位： 附属第一人民医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师： 兼
联系方式： 上海市松江区新松江路650号
邮编： 200080 邮箱地址： jhong.pku@163.com

研究方向 (点击浏览详细信息)
心律失常与心衰的流行病学和病理生理机制
群体灾难事件的预防和急救

社会任职
海峡两岸医药卫生交流协会心血管专业委员会 常委
中国生物技术协会心电学分会 全国委员
中国心律学会急诊工作委员会 全国委员
上海市中西医结合学会脑心同治专业委员会 常委
虹口区医学会急诊专委会 主任委员
上海市中西医结合学会急诊专业委员会 常委
中国中西医结合学会脑心同治委员会心律失常学组 委员
台海医学会心律专业委员会 常委

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
2017SJKJGG31 GRK2在丙泊酚抗心肌缺血再灌注损伤中的作用机制研究 松江区科技攻关项目 2018-01~2019-12 8万元 课题负责人
** 丙泊酚调节GRK2-β2-肾上腺素受体通路在缺血性心律失常中的作用机制 国家自然科学基金面上项目 2016-01~2019-12 57万元 课题负责人
** 环氧20碳－三烯酸通过Smad7抗心房纤维化/房颤的机制 国家自然基金青年基金 2014-01~2016-12 23万元 课题参与人
YG2013MS04 基于云计算技术远程无线心电监护与心律失常管理平台的建立 上海交通大学医工交叉项目 2013-12~2016-12 15万元 课题负责人
11B24 丙泊酚对Katp通道的调节与抗室性心律失常作用机制研究 上海交通大学医学院科研基金 2013-01~2015-12 6万元 课题负责人
WS** 吸烟与房颤发生的关系 辉瑞中国控烟科研基金 2012-01~2013-12 5万元 课题负责人
06BZ065 导管消融致犬肺静脉狭窄的机制研究 上海市教委科研基金 2007-01~2009-01 5万元 课题负责人
2007CB512008 心力衰竭致猝死的危险性评估和早期预警 国家973课题子课题 2007-01~2009-01 8万元 课题参与人
犬肺静脉冷冻消融治疗房颤的试验研究 中国博士后科学基金一等资助 2006-07~2007-12 5万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Zhou D, Zhuang J, Wang Y, Zhao D, Zhao L, Zhu S, Pu J, Yin M, Zhang H, Wang Z, Hong J. （通讯作者） Propofol Alleviates DNA Damage Induced by Oxygen Glucose Deprivation and Reperfusion via FoxO1 Nuclear Translocation in H9c2 Cells. Front Physiol 2019 10:223.
Gao J#, Zhao L#, Wang J, Zhang L, Zhou D, Qu J, Wang H, Yin M, Hong J* （通讯作者）, Zhao W*. C-Phycocyanin Ameliorates Mitochondrial Fission and Fusion Dynamics in Ischemic Cardiomyocyte Damage. Front Pharmacol 2019 10:733
Pu J#, Zhu S #, Zhou D, Zhao L, Yin M, Wang Z*, Hong J*. （通讯作者） Propofol alleviates apoptosis induced by chronic high glucose exposure via regulation of HIF-1a in H9c2 Cells. Oxid Med Cell Longev 2019 2019: ID **
Zhao L, Zhuang J, Wang Y, Zhou D, Zhao D, Zhu S, Pu J, Zhang H, Yin M, Zhao W, Wang Z, Hong J. （通讯作者） Propofol Ameliorates H9c2 Cells Apoptosis Induced by Oxygen Glucose Deprivation and Reperfusion Injury via Inhibiting High Levels of Mitochondrial Fusion and Fission. Front Pharmacol 2019 10:61
Wang Y, Chen B, Huang CK, Guo A, Wu J, Zhang X, Chen R, Chen C, Kutschke W, Weiss RM, Boudreau RL, Margulies KB, Hong J* （通讯作者）, Song LS*. Targeting Calpain for Heart Failure Therapy: Implications From Multiple Murine Models. JACC Basic Transl Sci 2018 3(4):503-517
Guo A, Wang Y, Chen B, Wang Y, Yuan J, Zhang L, Hall D, Wu J, Shi Y, Zhu Q, Chen C, Thiel WH, Zhan X, Weiss RM, Zhan F, Musselman CA, Pufall M, Zhu W, Au KF, Hong J, Anderson ME, Grueter CE, Song LS*. E-C coupling structural protein junctophilin-2 encodes a stress-adaptive transcription regulator. SCIENCE 2018 362(6421). pii: eaan3303
Guo A#, Chen R#, Wang Y, Huang CK, Chen B, Kutschke W, Hong J, Song LS*. Transient activation of PKC results in long-lasting detrimental effects on systolic [Ca(2+)](i) in cardiomyocytes by altering actin cytoskeletal dynamics and T-tubule integrity. J Mol Cell Cardiol 2018 115:104-114.
Zhang C#, Chen B#, Wang Y#, Guo A, Tang Y, Khataei T, Shi Y, Kutschke WJ, Zimmerman K, Weiss RM, Liu J, Benson CJ, Hong J, Ma J, Song LS*. MG53 is dispensable for T-tubule maturation but critical for maintaining T-tubule integrity following cardiac stress. J Mol Cell Cardiol 2017 112: 123-130.
Huang CK, Chen BY, Guo A, Chen R, Zhu YQ, Kutschke W, Hong J* （通讯作者）, Song LS. Sildenafil ameliorates left ventricular T-tubule remodeling in a pressure overload-induced murine heart failure model. Acta Pharmacologica Sinica 2016 37(4): 473-482
Zhu Y, Zhang C, Chen B, Chen R, Guo A, Hong J, Song LS. Cholesterol is required for maintaining T-tubule integrity and intercellular connections at intercalated discs in cardiomyocytes. J Mol Cell Cardiol 2016 97:204-12
Ding X#, Zheng X#, Xing A, Wang D, Qi S, Wu Y, Li H, Wu S, Hong J*. （通讯作者） Predictive factors of atrial fibrillation in type 2 diabetic patients: results from Chinese Kailuan study. QJM 2015 108(11):885-890
Zhao D, Li Q, Huang Q, Li X, Yin M, Wang Z*, Hong J*. （通讯作者） Cardioprotective effect of propofol against oxygen glucose deprivation and reperfusion injury in H9c2 cells. Oxidative Medicine and Cellular Longevity 2015 2015: ID 184938
Hong J, Xu MD, Kong AL, Liu Q, Chen R, Dai QY, Wang L, Sun BG*. Propofol terminates ventricular fibrillation storm caused by pulmonary embolism. Chin Med J (Engl) 2014 127(21 ):3840-3840.
Li X, Zhao G, Ma B, Li R, Hong J, Liu S, Wang DW*. 20-hydroxyeicosatetraenoic Acid impairs endothelial insulin signaling by inducing phosphorylation of the insulin receptor substrate-1 at ser616. PLoS One 2014 9(4): e95841
Liu Q, Wang T, Chen R, Liu C, Yue W, Hong J, Jia R*. Mean platelet volume predicts left descending artery occlusion in patients with non-ST-elevation myocardial infarction. Platelets 2014 25(4):246-251.
Zhang C, Chen B, Guo A, Zhu Y, Miller JD, Gao S, Yuan C, Kutschke W, Zimmerman K, Weiss RM, Wehrens XH, Hong J, Johnson FL, Santana LF, Anderson ME, Song LS*. Microtubule-Mediated Defects in Junctophilin-2 Trafficking Contribute to Myocyte T-Tubule Remodeling and Ca2+ Handling Dysfunction in Heart Failure. Circulation 2014 129(17):1742-50.
Yu K, Xing A, Wang D, Qi S, Wang G, Chen R, Wang Y, Wu S*, Hong J*. （通讯作者） Prevalence and relative risk factors of atrial fibrillation in male coal miners in North China. Int J Cardiol 2014 174(1): 223-224.
Chen B, Guo A, Zhang C, Chen R, Zhu Y, Hong J, Kutschke W, Zimmerman K, Weiss RM, Zingman L, Anderson ME, Wehrens XH, Song LS*. Critical roles of Junctophilin-2 in T-tubule and excitation-contraction coupling maturation during postnatal development. Cardiovasc Res 2013 100(1):54-62.
Liu Q, Yao JY, Qian C, Chen R, Li XY, Liu SW, Sun BG, Song LS, Hong J*. （通讯作者） Effects of propofol on ischemia-induced ventricular arrhythmias and mitochondrial ATP-sensitive potassium channels. Acta Pharmacol Sin 2012 33(12):1495-501
Liu Q,Kong A, Chen R, Qian C, Liu S, Sun B, Wang L, Song L, Hong J. （通讯作者） Propofol and arrhythmias: two sides of the coin. Acta Pharmacologica Sinica 2011 32(8):817-823
Zou N, Hong J, Dai QY*. Passive cigarette smoking induces inflammatory injury in human arterial wall. Chinese Medical Journal 2009 122(4):444-448
Huang WB, Hong J* （通讯作者）, Wang Y, Zhou FG, Zeng ZB, Gong Y. Ablation of left-deviated dual atrioventricular nodal pathway from coronary sinus. Chinese Medical Journal 2009 122(5):593-595
Hong J, Guo J, Li X. Radiofrequency Ablation of a Posteroseptal Atrioventricular Accessory Pathway in a Patient with Mechanical Mitral Valve. Heart 2005 91(1):43-43