导师姓名： 王传贵 专业代码： 100214
性别： 男 专业名称： 肿瘤学
培养单位： 附属第一人民医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： cgwang2016@sjtu.edu.cn
邮编： cgwang2016@sjtu.edu.cn 邮箱地址： cgwang@bio.ecnu.edu.cn

研究方向 (点击浏览详细信息)
1、肿瘤分子生物学； 2、细胞代谢紊乱机制； 3、天然产物及大分子药物研发

社会任职

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** KLF14翻译后修饰及其在调控肿瘤细胞死亡中的作用研究 国家自然科学基金面上项目 2020-01~2023-12 58万元 课题负责人
**-2 Sirtuin与代谢紊乱及转化研究 医学院临床专职科研队伍 2019-01~2021-12 100万元 课题负责人
** 去乙酰化酶SirT7在应激反应及肿瘤细胞死亡中的作用及调控研究 国家自然科学基金 2017-01~2020-12 62万元 课题负责人
2016YFC** 2型糖尿病表观遗传信息的建立和维持机制及可塑性研究 国家重点研发计划 2016-09~2020-12 120万元 课题负责人
** Sirtuin与代谢紊乱及转化研究 医学院临床专职科研队伍 2016-01~2018-12 100万元 课题负责人
** 真核生物mRNA poly(A)结合蛋白(PABP)功能及调控研究 国家自然科学基金面上项目 2014-01~2017-12 70万元 课题负责人
** 蛋白酶体激活因子通过负调控Sirtuin参与细胞自噬和核糖体胁迫的新功能发现和机制研究 国家自然科学基金青年科学基金项目 2013-01~2015-12 23万元 课题参与人
** 线粒体去乙酰化酶SirT3功能研究 国家自然科学基金面上项目 2012-01~2015-12 60万元 课题负责人
** KAP1翻译后修饰机制及其参与细胞周期调控功能研究课题 国家自然科学基金面上项目 2011-01~2013-12 32万元 课题负责人
** 半导体复合纳米材料光电分析方法构建及其在乙酰胆碱酯酶活性检测中的应用研究 华东师范大学科研创新基金重点项目 2010-01~2012-06 40万元 课题参与人
2008B39 SirT1去乙酰化酶与肿瘤关系 华东师范大学科研创新基金重点项目 2010-01~2011-12 40万元 课题负责人
2009CB918401 蛋白质翻译后修饰和动态相互作用的机制与效应研究课题 科技部973计划 2009-01~2013-08 170万元 子课题负责人
NCET-08-0194 KAP1参与肿瘤细胞生长和凋亡机制研究 2008教育部“新世纪优秀人才支持计划” 2009-01~2010-12 50万元 课题负责人
08PJ14042 SirT1生物活性调控及其与肿瘤关系研究 上海市科委浦江人才计划 2008-09~2010-10 30万元 课题负责人
2009BAK43B31 2010年世博期间主要输入性传染病及危害因子的快速筛检和应急处置体系建立的研究课题 科技部发展计划项目 2008-01~2010-12 28万元 课题参与人
07SG28 SirT1核质运转与肿瘤关系研究 上海市教育委员会曙光计划 2008-01~2010-12 15万元 课题负责人
** SirT1磷酸化修饰及其生物学功能研究 国家自然科学基金面上项目 2008-01~2011-12 28万元 课题负责人
08ZZ23 SirT1蛋白修饰与肿瘤耐辐射和耐药性关系的研究 上海市教育委员会科研创新重点项目 2008-01~2010-12 15万元 课题负责人
** 华东师范大学985平台建设重点课题 “985工程”专项资金 2007-01~2013-12 300万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Tianshi Wang, Ying Cao, Quan Zheng, Jun Tu, Wei Zhou, Jianli He, Jie Zhong, Yalan Chen, Jiqiu Wang, Rong Cai, Yong Zuo, Bo Wei, Qiuju Fan, Jie Yang, Yicheng Wu, Jing Yi, Dali Li, Mingyao Liu, Chuangui Wang, Aiwu Zhou, Yu Li, Xuefeng Wu, Wen Yang, Y. Eugene Chin, Guoqiang Chen, and Jinke Cheng SENP1-Sirt3 Signaling Controls Mitochondrial Protein Acetylation and Metabolism Molecular Cell 2019 75, 1-12
He S, Cheng J, Sun L, Wang Y, Wang C, Liu X, Zhang Z, Zhao M, Luo Y, Tian L, Li C, Huang Q HMGB1 released by irradiated tumor cells promotes living tumor cell proliferation via paracrine effect. Cell Death Dis. 2018 May 29;9(6):648.
Shan P, Fan F, Sun L, Liu J, Wang W, Hu C,Zhang X, Zhai Q,Song X, Cao L, Cui Y , Zhang S, and Wang C （通讯作者） SIRT1 Functions as a Negative Regulator of Eukaryotic Poly(A)RNA Transport Current Biology 2017 27：2271-2284
Klionsky DJ, Abdelmohsen K, ---- Wang C ---- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) Autophagy 2016 12:1, 1-222
Song B, Cui H, Li Y, Cheng C, Yang B, Wang F, Kong P, Li H, Zhang L, Jia Z, Bi Y, Wang J, Zhou Y, Liu J, Wang J, Zhao Z, Zhang Y, Hu X, Shi R, Yang J, Liu H, Yan T, Li Y, Xu E, Qian Y, Xi Y, Guo S, Chen Y, Wang J, Li G, Liang J, Jia J, Chen X, Guo J, Wang T, Zhang Y, Li Q, Wang C, Cheng X, Zhan Q, Cui Y Mutually exclusive mutations in NOTCH1 and PIK3CA associated with clinical prognosis and chemotherapy responses of esophageal squamous cell carcinoma in China Oncotarget 2016 7(3):3599-613
Sun L, Fan G, Shan P, Qiu X, Dong S, Liao L, Yu C, Wang T, Gu X, Li Q, Song X, Cao L, Li X, Cui Y, Zhang S, Wang C （通讯作者） Regulation of energy homeostasis by the ubiquitin-independent REGγ proteasome Nature Communications 2016 7:12497. doi: 10.1038/ncomms12497.
Zhang X, Ren X, Zhang Q, Li Z, Ma S, Bao J, Li Z, Bai X, Zheng L, Zhang Z, Shang S, Zhang C, Wang C, Cao L, Wang Q, Ji J PGC-1α/ERRα-Sirt3 pathway regulates DAergic neuronal death by directly deacetylating SOD2 and ATP synthase β Antioxid Redox Signal. 2016 24(6):312-28
Cheng C, Cui H, Zhang L, Jia Z, Song B, Wang F, Li Y, Liu J, Kong P, Shi R, Bi Y, Yang B, Wang J, Zhao Z, Zhang Y, Hu X, Yang J, He C, Zhao Z, Wang J, Xi Y, Xu E, Li G, Guo S, Chen Y, Yang X, Chen X, Liang J, Guo J, Cheng X, Wang C, Zhan Q, Cui Y Genomic analyses reveal FAM84B and the NOTCH pathway are associated with the progression of esophageal squamous cell carcinoma Gigascience 2016 5:1. doi: 10.1186/s13742-015-0107-0
Fan G, Sun L, Shan P, Zhang X, Huan J, Zhang X, Li D, Wang T, Wei T, Zhang X, Gu X, Yao L, Xuan Y, Hou Z, Cui Y, Cao L, Li X, Zhang S, Wang C （通讯作者） Loss of KLF14 triggers centrosome amplification and tumorigenesis Nature Communications 2015 6:8450 ncomms9450.
Mu Zhang,Shengyan Xiang,Heui-Yun Joo,Lei Wang,Kendra A. Williams,Wei Liu,Chen Hu,Dan Tong,Joshua Haakenson,Chuangui Wang,Shengping Zhang,Ryan E. Pavlovicz,Amanda Jones,Kristina H. Schmidt,Jinfu Tang,Huiqin Dong,Bin Shan,Bin Fang,Rangasudhagar Radhakrishnan,Peter M. Glazer,Patrick Matthias,John Koomen,Edward Seto,Gerold Bepler,Santo V. Nicosia,Jiandong Chen,Chenglong Li,Liya Gu,Guo-Min Li,Wenlong Bai,Hengbin Wang,Xiaohong Zhang HDAC6 deacetylates and ubiquitinates MSH2 to maintain proper levels of MutSα. Molecular Cell 2014 55(1):31-46
An Y, Fu Y,Lu D, Wang Y, Bi W,Xu Z, Dong S, Zhang S, Wang C, Zhang W A TiO2-Au-polymer hybrid system for photoelectrochemical immunoassay of SirT1 J. Mater. Chem. B 2014 1644-1652
Liu J, Wang Y, Li L, Zhou L, Wei H, Zhou Q, Liu J, Wang W, Ji L, Shan P, Wang Y, Yang Y, Jung SY, Zhang P, Wang C, Long W, Zhang B, Li X Site-specific acetylation of the proteasome activator REGγdirects its heptameric structure and functions J Biol Chem 2014 288(23):16567-78
Fu Y, Liu K, Sun Q, Lin B, Lu D, Xu Z, Hu C, Fan G, Zhang S, Wang C, Zhang W A highly sensitive immunosensor for calmodulin assay based on enhanced biocatalyzed precipitation adopting a dual-layered enzyme strategy Biosens Bioelectron 2014 56:258-63
Dong S, Jia C, Zhang S, Fan G, Li Y, Shan P, Sun L, Xiao W, Li L, Zheng Y, Liu J, Wei H, Hu C, Zhang W, Chin YE, Zhai Q, Li Q, Liu J, Jia F, Mo Q, Edwards DP, Huang S, Chan L, O'Malley BW, Li X, Wang C. （通讯作者） The REGγ proteasome regulates hepatic lipid metabolism through inhibition of autophagy Cell Metabolism 2013 18(3):380-91
Zhou P, Wang Z, Yuan X, Zhou C, Liu L, Wan X, Zhang F, Ding X, Wang C, Xiong S, Wang Z, Yuan J, Li Q, Zhang Y Mixed lineage leukemia 5 (MLL5) protein regulates cell cycle progression and E2F1-responsive gene expression via association with host cell factor-1 (HCF-1) J Biol Chem 2013 288(24):17532-43
Williams KA, Zhang M, Xiang S, Hu C, Wu JY, Zhang S, Ryan M, Cox AD, Der CJ, Fang B, Koomen J, Haura E, Bepler G, Nicosia SV, Matthias P, Wang C, Bai W, Zhang X Extracellular signal-regulated kinase (ERK) phosphorylates histone deacetylase 6 (HDAC6) at serine 1035 to stimulate cell migration J Biol Chem 2013 288(46):33156-70
Liu J, Cheng X, Zhang Y, Li S, Cui H, Zhang L, Shi R, Zhao Z, He C, Wang C, Zhao H, Zhang C, Fisk HA, Guadagno TM, Cui Y Phosphorylation of Mps1 by BRAFV600E prevents Mps1 degradation and contributes to chromosome instability in melanoma Oncogene 2013 32(6):713-23
Fu Y, Lu D, Lin B, Sun Q, Liu K, Xu L, Zhang S, Hu C, Wang C, Xu Z, Zhang W Fluorescence assay for glycan expression on living cancer cells based on competitive strategy coupled with dual-functionalized nanobiocomposites Analyst 2013 138 (22): 7016 -22
Li P, Gao S, Wang L, Yu F, Li J, Wang C, Li J, Wong J ABH2 couples regulation of ribosomal DNA transcription with DNA alkylation repair Cell Rep 2013 4(4):817-29
Zang Y, Xiong J, Zhai WZ, Cao L, Zhang SP, Tang Y, Wang J, Su JJ, Yang GX, Zhao Y, Fan H, Xia G, Wang CG, Hu JF Fomentarols A-D, sterols from the polypore macrofungus Fomes fomentarius Phytochemistry 2013 92:137-45
Ding H, Gao YS, Hu C, Wang Y, Wang CG, Yin JM, Sun Y, Zhang CQ HIF-1α transgenic bone marrow cells can promote tissue repair in cases of corticosteroid-induced osteonecrosis of the femoral head in rabbits PLoS One 2013 8(5):e63628
Meng S, Zhang M, Pan W, Li Z, Anderson DH, Zhang S, Ge B, Wang C （通讯作者） Tyrosines 303/343/353 within the Sprouty-related domain of Spred2 are essential for its interaction with p85 and inhibitory effect on Ras/ERK activation Int J Biochem Cell Biol 2012 44(5):748-58
Hu C, Zhang S, Gao X, Gao X, Xu X, Lv Y, Zhang Y, Zhu Z, Zhang C, Li Q, Wong J, Cui Y, Zhang W, Ma L, Wang C. （通讯作者） Roles of Kruppel-associated Box (KRAB)-associated Co-repressor KAP1 Ser-473 Phosphorylation in DNA Damage Response J Biol Chem 2012 287(23):18937-52
An Y, Jiang X, Bi W, Chen H, Jin L, Zhang S, Wang C, Zhang W Sensitive electrochemical immunosensor for α-synuclein based on dual signal amplification using PAMAM dendrimer-encapsulated Au and enhanced gold nanoparticle labels Biosens Bioelectron 2012 32(1):224-30
Shen J, Zhang S, Li Y, Zhang W, Chen J, Zhang M, Wang T, Jiang L, Zou X, Wong J, Li X, Cui Y, Wang C （通讯作者） p14(ARF) inhibits the functions of adenovirus E1A oncoprotein Biochem J 2011 434(2):275-85
Zhang X, Teng Y, Fu Y,Zhang S, Wang T, Wang C, Jin L, Zhang W Lectin-based electrochemical biosensor constructed by functionalized carbon nanotubes for the competitive assay of glycan expression on living cancer cells Chem. Sci 2011 2353-60
Liu J, Yu G, Zhao Y, Zhao D, Wang Y, Wang L, Liu J, Li L, Zeng Y, Dang Y, Wang C, Gao G, Long W, Lonard DM, Qiao S, Tsai MJ, Zhang B, Luo H, Li X REGgamma modulates p53 activity by regulating its cellular localization J Cell Sci 2010 123(Pt 23):4076-84
Zhang Z, Zhang W, Ji YP, Zhao Y, Wang CG, Hu JF Gynostemosides A-E, megastigmane glycosides from Gynostemma pentaphyllum Phytochemistry 2010 71(5-6):693-700
Wu SB, Su JJ, Sun LH, Wang WX, Zhao Y, Li H, Zhang SP, Dai GH, Wang CG, Hu JF Triterpenoids and steroids from the fruits of Melia toosendan and their cytotoxic effects on two human cancer cell lines J Nat Prod 2010 73(11):1898-906
Meng S, Gui Q, Xu Q, Lu K, Jiao X, Fan J, Ge B, Ke Y, Zhang S, Wu J, Wang C （通讯作者） Association of Shp2 with phosphorylated IL-22R1 is required for interleukin-22-induced MAP kinase activation J Mol Cell Biol 2010 2(4):223-30
Zhang X, Teng Y, Fu Y, Xu L, Zhang S, He B, Wang C （通讯作者）, Zhang W Lectin-based biosensor strategy for electrochemical assay of glycan expression on living cancer cells Anal Chem 2010 82(22):9455-60
Cui Y, Cheng X, Zhang C, Zhang Y, Li S, Wang C, Guadagno TM Degradation of the human mitotic checkpoint kinase Mps1 is cell cycle-regulated by APC-cCdc20 and APC-cCdh1 ubiquitin ligases J Biol Chem 2010 285(43):32988-98
An Y, Tang L, Jiang X, Chen H, Yang M, Jin L, Zhang S, Wang C, Zhang W A photoelectrochemical immunosensor based on Au-doped TiO2 nanotube arrays for the detection of α-synuclein CHEM-EUR J 2010 16(48):14439-46
Li Z, Chen L, Kabra N, Wang C, Fang J, Chen J Inhibition of SUV39H1 methyltransferase activity by DBC1 J Biol Chem 2009 284(16):10361-6
Kabra N, Li Z, Chen L, Li B, Zhang X, Wang C, Yeatman T, Coppola D, Chen J SirT1 is an inhibitor of proliferation and tumor formation in colon cancer J Biol Chem 2009 284(27):18210-7
Wang C, Rauscher FJ 3rd, Cress WD, Chen J Regulation of E2F1 function by the nuclear corepressor KAP1 J Biol Chem 2007 282(41):29902-9
Wang C, Chen L, Hou X, Li Z, Kabra N, Ma Y, Nemoto S, Finkel T, Gu W, Cress WD, Chen J Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage Nat Cell Biol 2006 8(9):1025-31
Wang C, Hou X, Mohapatra S, Ma Y, Cress WD, Pledger WJ, Chen J Activation of p27Kip1 Expression by E2F1. A negative feedback mechanism J Biol Chem. 2005 280(13):12339-43
Wang C, Ivanov A, Chen L, Fredericks WJ, Seto E, Rauscher FJ 3rd, Chen J MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation EMBO J 2005 24(18):3279-90
Wang C, Chen J Phosphorylation and hsp90 binding mediate heat shock stabilization of p53 J Biol Chem 2003 278(3):2066-71
Wu J, Wang C, Mei X. Stimulation of taxol production and excretion in Taxus spp cell cultures by rare earth chemical lanthanum J Biotechnol. 2001 85(1):67-73
Wang C, Wu J, Mei X. Enhanced taxol production and release in Taxus chinensis cell suspension cultures with selected organic solvents and sucrose feeding Biotechnol Prog. 2001 17(1):89-94
Wang C, Wu J, Mei X. Enhancement of Taxol production and excretion in Taxus chinensis cell culture by fungal elicitation and medium renewal Appl Microbiol Biotechnol. 2001 55(4):404-10