导师姓名： 田恒力 专业代码： 100210
性别： 男 专业名称： 外科学
培养单位： 附属第六人民医院 三级学科/
专业领域： 神外
导师类型： 博士生导师 专业学位导师： 兼
联系方式： tianhlsh@126.com
邮编： 200233 邮箱地址： tianhlsh@126.com

研究方向 (点击浏览详细信息)
中枢神经系统损伤及修复

社会任职
中华医学会神经外科分会全国委员
中华医学会创伤学分会全国委员
中华创伤学分会神经创伤专业委员会常委
中国医师协会神经损伤培训委员会常委
中国神经重症协作组常委
上海市神经外科学会委员兼秘书
上海市医师协会神经外科医师分会副会长
上海市创伤学会副主任委员
上海市颅脑创伤研究所副所长
中华医学会医疗事故技术鉴定专家
国家自然科学基金评审专家
教育部研究生学位论文评审专家
上海市卫生高级职称评审专家
《Neuroscience Bulletin》、《中华神经外科杂志》英文版、《中华神经创伤杂志》、《上海医学》、《中国临床神经科学》、《现代外科杂志》等杂志编委、常务编委、理事等。

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
070 上海市领军人才 上海市人力资源和社会保障局 2020-05~2023-04 160万元 课题负责人
** NAADP调节TBI后脑细胞间线粒体转移及其在神经损伤修复作用研究 国家自然科学基金面上项目 2020-01~2023-12 55万元 课题负责人
** 最适脑灌注压为导向的颅脑创伤患者精准化治疗 上海市科委科技创新行动计划 2019-01~2022-03 30万元 课题负责人
** SIRT2调控MEK乙酰化修饰及其在创伤性脑损伤后神经损伤修复作用和机制的研究 国家自然科学基金面上项目 2017-01~2020-12 57万元 课题负责人
** miRNA-21调节PTEN表达及其在创伤后神经元和脑血管内皮细胞损伤修复中的作用和机理研究 国家自然科学基金面上项目 2015-01~2018-12 70万元 课题负责人
**/** 合并颅脑创伤多发伤早期评估及损伤控制外科理论在其诊治中的应用研究 上海市科委科技创新行动计划 2013-07~2016-10 30万元 课题负责人
** 机械敏感TRP 通道调节SUR1 表达变化及其在脑挫伤后进展性出 血中的作用及机理研究 国家自然科学基金面上项目 2013-01~2016-12 70万元 课题负责人
10JC** 颅脑创伤后进展性脑损害的数据库建立、危险因素分析和治疗策略 上海市科委重点项目 2010-10~2013-09 30万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Yao Jing, Dian-Xu Yang, Wei Wang, Fang Yuan, Hao Chen, Jun Ding, Zhi Geng, Heng-Li Tian. （通讯作者） Aloin Protects Against Blood-Brain Barrier Damage After Traumatic Brain Injury in Mice. Neurosci Bull 2020 36(6):625-638
Pan-Ting Zhou, Li-Ping Wang, Mei-Jie Qu, Hui Shen, Hao-Ran Zheng, Li-Dong Deng, Yuan-Yuan Ma, Yu-Yang Wang, Yong-Ting Wang, Yao-Hui Tang, Heng-Li Tian （通讯作者）, Zhi-Jun Zhang, Guo-Yuan Yang. Dl-3-N-butylphthalide promotes angiogenesis and upregulates sonic hedgehog expression after cerebral ischemia in rats. CNS Neurosci Ther 2019 25(6):748–758
Yang DX, Jing Y, Liu YL, Xu ZM, Yuan F, Wang ML, Geng Z, Tian HL. （通讯作者） Inhibition of Transient Receptor Potential Vanilloid 1 Attenuates Blood-Brain Barrier Disruption after Traumatic Brain Injury in Mice. J Neurotrauma 2019 36(8):1279-1290
Li Z, Gu Y, Wen R, Shen F, Tian HL （通讯作者）, Yang GY, Zhang Z. Lysosome exocytosis is involved in astrocyte ATP release after oxidative stress induced by H2O2. Neurosci Lett 2019 705:251-258
Jing Y, Yang D, Fu Y, Wang W, Yang G, Yuan F, Chen H, Ding J, Chen S, Tian H. （通讯作者） Neuroprotective Effects of Serpina3k in Traumatic Brain Injury. Front Neurol 2019 10:1215
Yang DX, Jing Y, Xu ZM, Yuan F, Liu YL, Wang GS, Tian HL. （通讯作者） Primary glioblastoma of the cerebellopontine angle in an adult mimicking an acoustic neuroma. World Neurosurg 2019 122:48-52
Jing Y, Zhang L, Xu Z, Chen H, Ju S, Ding J, Guo Y, Tian H. （通讯作者） Phosphatase Actin Regulator-1 (PHACTR-1) Knockdown Suppresses Cell Proliferation and Migration and Promotes Cell Apoptosis in the bEnd.3 Mouse Brain Capillary Endothelial Cell Line. Med Sci Monit 2019 25:1291-1300
Liu YL, Yuan F, Yang DX, Xu ZM, Jing Y, Yang GY, Geng Z, Xia WL, Tian HL. （通讯作者） Adjudin Attenuates Cerebral Edema and Improves Neurological Function in Mice with Experimental Traumatic Brain Injury. J Neurotrauma 2018 35(23):2850-2860
Z Xu, Y Liu, D Yang, F Yuan, J Ding, L W, M Qu, G Yang, H Tian. （通讯作者） Glibenclamide–sulfonylurea receptor 1 antagonist alleviates LPS-induced BV2 cell activation through the p38/MAPK pathway. Rsc Advances 2017 7(44):27206-27213
Xu Z, Liu Y, Yang D, Yuan F, Ding J, Chen H, Tian H. （通讯作者） Sesamin protects SH-SY5Y cells against mechanical stretch injury and promoting cell survival. BMC Neurosci 2017 18(1):57
Chen H, Yuan F, Chen SW, Guo Y, Wang G, Deng ZF, Tian HL. （通讯作者） Predicting posttraumatic hydrocephalus: derivation and validation of a risk scoring system based on clinical characteristics. Metab Brain Dis 2017 32(5):1427-1435
Xu ZM, Yuan F, Liu YL, Ding J, Tian HL. （通讯作者） Glibenclamide Attenuates Blood-Brain Barrier Disruption in Adult Mice after Traumatic Brain Injury J Neurotrauma 2017 34(4):925-933
Liu YL, Xu ZM, Yang GY, Yang DX, Ding J, Chen H, Yuan F, Tian HL. （通讯作者） Sesamin alleviates blood-brain barrier disruption in mice with experimental traumatic brain injury. Acta Pharmacol Sin 2017 38(11):1445-1455
Yuan F, Xu ZM, Lu LY, Nie H, Ding J, Ying WH, Tian HL. （通讯作者） SIRT2 inhibition exacerbates neuroinflammation and blood-brain barrier disruption in experimental traumatic brain injury by enhancing NF-κB p65 acetylation and activation. J Neurochem 2016 136(3):581-93
Liu J, Tian HL （通讯作者） Relationship between trauma-induced coagulopathy and progressive hemorrhagic injury in patients with traumatic brain injury Chin J Traumatol. 2016 19(3):172-5
Jun Ding, Zhengang Ding, Fang Yuan, Jianyi Guo, Hao Chen, Wenwei Gao, Ren Wang, Yi Gu, Jiong Chen, Yan Guo, Hengli Tian （通讯作者） Proteomics analysis after traumatic brain injury in rats: the search for potential biomarkers Arq Neuropsiquiatr 2015 73(4):342-9
Wang XY, Ba YC, Xiong LL, Li XL, Zou Y, Zhu YC, Zhou XF, Wang TH, Wang F, Tian HL （通讯作者）, Li JT. Endogenous TGFβ1 Plays a Crucial Role in Functional Recovery After Traumatic Brain Injury Associated with Smad3 Signal in Rats. Neurochem Res 2015 40(8):1671-80
Wang R, Li M, Gao WW, Guo Y, Chen J, Tian HL. （通讯作者） Outcomes of Early Decompressive Craniectomy Versus Conventional Medical Management After Severe Traumatic Brain Injury: A Systematic Review and Meta-Analysis. Medicine (Baltimore) 2015 94(43):e1733
Ding J, Guo Y, Tian H. （通讯作者） The infuluence of decompressive craniectomy on the development of hydrocephalus: A review Arq Neuropsiquiatr 2014 72(9):715-20
Wang R, Li M, Gao WW, Gu Y, Guo Y, Wang G, Tian HL. （通讯作者） Quantitative assessment of the association between XRCC3 C18607T polymorphism and glioma risk. Tumour Biol 2014 35(2):1101-5
Chen H, Xue LX, Guo Y, Chen SW, Wang G, Cao HL, Chen J, Tian HL. （通讯作者） The influence of hemocoagulation disorders on the development of posttraumatic cerebral infarction and outcome in patients with moderate or severe head trauma. Biomed Res Int 2013 (2013):6851-74
Guo JY, Ding J, Yuan F, Chen H, Chen SW, Tian HL. （通讯作者） Dose-Dependent Protective Effect of Bisperoxovanadium against Acute Cerebral Ischemia in a Rat Model of Ischemia/Reperfusion Injury. Int J Mol Sci 2013 14(6):12013-12022
Ding J, Yuan F, Guo JY, Chen H, Tian HL. （通讯作者） Influence of glibenclamide on outcome in patients with type 2 diabetes and traumatic brain injury Clin Neurol Neurosurg 2013 (115):2166-2169
Ding J, Guo J, Yuan Q, Yuan F, Chen H, Tian H. （通讯作者） Inhibition of phosphatase and tensin homolog deleted on chromosome 10 decreases rat cortical neuron injury and blood-brain barrier permeability, and improves neurological functional recovery in trauma PLoS One 2013 (8):804-29
Chen H, Xue LX, Cao HL, Chen SW, Guo Y, Gao WW, Ju SM, Tian HL. （通讯作者） Endostatin/collagen XVIII is increased in cerebrospinal fluid after severe traumatic brain injury. Biomed Res Int 2013 (2013):402-375
Dai D, Yuan Q, Sun Y, Yuan F, Su Z, Ding J, Tian H. （通讯作者） Impact of Thoracic Injury on Traumatic Brain Injury Outcome PLoS One 2013 (8):742-04
Ding J, Yuan F, Guo Y, Chen SW, Gao WW, Wang G, Cao HL, Ju SM, Chen H, Zhang PQ, Tian HL. （通讯作者） A prospective clinical study of routine repeat computed tomography (CT) after traumatic brain injury (TBI). Brain Inj 2012 26(10):1211-6
Fang Yuan,Jun Ding, Hao Chen, Yan Guo, Gan Wang, Wen-Wei Gao, Shi-Wen Chen, Heng-Li Tian （通讯作者） Predicting Progressive Hemorrhagic Injury after Traumatic Brain Injury: Derivation and Validation of a Risk Score Based on Admission Characteristics JOURNAL OF NEUROTRAUMA 2012 29(12):2137-42
Guo Y, Wang G, Gao WW, Cheng SW, Wang R, Ju SM, Cao HL, Tian HL. （通讯作者） Induction of apoptosis in glioma cells and upregulation of Fas expression using the human interferon-β gene. Asian Pac J Cancer Prev 2012 13(6):2837-40
Fang Yuan, Jun Ding,Hao Chen, Yan Guo,Gan Wang, Wen-Wei Gao, Shi-Wen Chen, Heng-Li Tian （通讯作者） Predicting outcomes after traumatic brain injury: The development and validation of prognostic models based on admission characteristics J Trauma Acute Care Surg 2012 73(1):137-145
Tian HL, Chen H, Wu BS, Cao HL, Xu T, Hu J, Wang G, Gao WW, Lin ZK, Chen SW. D-dimer as a predictor of progressive hemorrhagic injury in patients with traumatic brain injury: analysis of 194 cases. Neurosurg Rev 2010 33(3):359-65
Heng-Li Tian, Yan Guo, Jin Hu, Bo-Ying Rong, Gan Wan, Wen-Wei Gao, Shi-Wen Chen and Hao Chen. Clinical characterization of comatose patients with cervical spine injury and traumatic brain injury. J of Trauma 2009 67(6):1305-10
Heng-Li Tian, Tao Xu, Jin Hu, Yu-Hui Cui, Hao Chen, Liang-Fu Zhou. Risk factors related to hydrocephalus after traumatic subarachnoid hemorrhage. Surg Neurol 2008 69(3): 241-246
Heng-Li Tian, Zhi Geng, Yu-Hui Cui, Jin Hu, Tao Xu, He-Li Cao, Shi-Wen Chen and Hao Chen. Risk factors for posttraumatic cerebral infarction in patients with moderate or severe head trauma. Neurosurgical Review 2008 31(4):431-437
Heng-Li Tian, Shi-Wen Chen, Tao Xu, Jin Hu, Bo-Ying Rong, Gan Wan, Wen-Wei Gao and Hao Chen. Risk factors related to hospital mortality in patients with isolated traumatic acute subdural haematoma: analysis of 308 patients undergone surgery. Chin Med J 2008 121(12):1080-1084
Heng-Li Tian, Hao Chen, Yu-Hui Cui, Tao Xu and Liang-Fu Zhou. Increased protein and mRNA expression of endostatin in the ischemic brain tissue of rabbits after middle cerebral artery occlusion. Neuroscience Bulletin 2007 23(1): 35-40