导师姓名： 于晓巍 专业代码： 100210
性别： 男 专业名称： 外科学
培养单位： 附属第六人民医院 三级学科/
专业领域： 骨外
导师类型： 博士生导师 专业学位导师： 兼
联系方式： yuxw@sjtu.edu.cn
邮编： 邮箱地址： yuxw@sjtu.edu.cn

研究方向 (点击浏览详细信息)
股骨头坏死
骨免疫与骨修复
骨与关节损伤

社会任职
国际矫形与创伤外科学会(SICOT)中国部创伤学会委员
上海市医师协会骨科医师分会关节组委员
《中华创伤杂志英文版》通讯编委
白求恩公益基金会老年髋部骨折专业委员会委员
Annals of Translational Medicine 编委
Medicine Research高级编辑委员会成员
上海市医学会创伤专科分会委员
中国医疗保健国际交流促进会创伤学会委员
中华医学会骨科学分会运动医学学组青年委员
中华医学会创伤学分会青年委员
中华医学会医学工程学分会数字骨科学组工作委员会（数字骨科创伤与关节工作委员会）委员
General Chemistry高级编辑委员会成员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
PKJ2019-Y02 基于仿真分析软件为主体的人工智能用于单间室膝关节炎的截骨方案优化设计 上海市浦东新区科技发展基金民生科研专项资金医疗卫生项目 2019-12~2022-11 36万元 课题负责人
SHDC12019X24 Anybody软件结合人工智能辅助截骨方案优化设计治疗内侧间室膝关节炎 上海申康医院发展中心临床科技创新项目 2019-11~2022-11 30万元 课题负责人
DYZD201803 Anybody软件在闭合楔形胫骨高位截骨手术中的应用 上海市第六人民医院东院临床研究重点专项 2019-01~2021-12 15万元 课题负责人
** 双控释骨支架的制备及其在感染性骨缺损中的应用及机制研究 国自然面上项目 2019-01~2022-12 57万元 课题负责人
2018BR38 上海市卫生计生系统优秀学科带头人培养计划 上海市卫计委 2018-09~2021-06 45万元 课题负责人
** 程序释放VEGF/BMP载药系统强化磷酸钙治疗股骨头缺血性坏死的研究 国家自然科学基金委员会 2016-01~2019-12 68.4万元 课题负责人
ZY3-CCCX-3-3044 人参果治疗骨质疏松症及骨质疏松骨折的应用研究 上海市进一步加快中医药事业发展三年行动计划（2014年-2016年） 2014-09~2016-12 50万元 课题负责人
14ZR** 同轴纳米PCL/PVA纤维载红霉素强化磷酸钙治疗骨髓炎的实验研究 上海市自然科学基金项目 2014-07~2017-06 10万元 课题负责人
** 组织工程软骨-骨复合移植物的仿生构建 国家自然科学基金面上项目 2011-01~2013-12 33万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Jiang F, Zong Y, Ma X, Jiang C,Shan H, Lin Y, Xia W, Yin F, Wang N, Zhou L, Zhou Z, Yu X （通讯作者） MiR-26a attenuated bone-specific insulin resistance and bone quality in diabetic mice Mol Ther Nucleic Acids 2020 20:459-467
Zhang W, Liu J, Shan H, Yin F, Zhong B, Zhang C, Yu X （通讯作者） Machine learning-guided evolution of BMP-2 knuckle Epitope-Derived osteogenic peptides to target BMP receptor II J Drug Target 2020 1-9
Zhou Z, Lin Y, Pan C, Wang N, Zhou L, Shan H, Gao Y, Yu X （通讯作者） IL-15 deficiency alleviates steroid-induced osteonecrosis of the femoral head by impact osteoclasts via RANKL-RANK-OPG system Immun Ageing 2020 17:19
Wu T, Yin F, Wang N, Ma X, Jiang C, Zhou L, Zong Y, Shan H, Xia W, Lin Y, Zhou Z, Yu X （通讯作者） Involvement of mechanosensitive ion channels in the effects of mechanical stretch induces osteogenic differentiation in mouse bone marrow mesenchymal stem cells J Cell Physiol 2020 doi: 10.1002/jcp.29841
Zhang W, Zhang C, Hu C, Luo C, Zhong B, Yu X （通讯作者） Circular RNA-CDR1as acts as the sponge of microRNA-641 to promote osteoarthritis progression J Inflamm (Lond) 2020 17:8
Jiang C, Xia W, Wu T, Pan C, Shan H, Wang F, Zhou Z, Yu X （通讯作者） Inhibition of microRNA-222 up-regulates TIMP3 to promotes osteogenic differentiation of MSCs from fracture rats with type 2 diabetes mellitus J Cell Mol Med 2020 24(1):686-694
Jiang F, Shan H, Pan C, Zhou Z, Cui K, Chen Y, Zhong H, Lin Z, Wang N, Yan L, Yu X （通讯作者） ATP6V1H facilitates osteogenic differentiation in MC3T3-E1 cells via Akt/GSK3β signaling pathway Organogenesis 2019 15(2):43-54
Jiang F, Yin F, Lin Y, Xia W, Zhou L, Pan C, Wang N, Shan H, Zhou Z, Yu X （通讯作者） The promotion of bone regeneration through CS/GP-CTH/antagomir-133a/b sustained release system Nanomedicine 2019 24:102116
Pan C, Shan H, Wu T, Liu W, Lin Y, Xia W, Wang F, Zhou Z, Yu X （通讯作者） 20(S)-Protopanaxadiol Inhibits Titanium Particle-Induced Inflammatory Osteolysis and RANKL-Mediated Osteoclastogenesis via MAPK and NF-κB Signaling Pathways Front Pharmacol 2019 9:1538
Zhou Z, Pan C, Wang N, Zhou L, Shan H, Gao Y, Yu X （通讯作者） A high-fat diet aggravates osteonecrosis through a macrophage-derived IL-6 pathway Int Immunol 2019 31(4):263-273
Pan C, Zhou Z, Yu X （通讯作者） Coatings as the useful drug delivery system for the prevention of implant-related infections J Orthop Surg Res 2018 13(1):220
Zhou Z, Seta J, Markel DC, Song W, Yurgelevic SM, Yu XW （通讯作者）, Ren W. Release of vancomycin and tobramycin from polymethylmethacrylate cements impregnated with calcium polyphosphate hydrogel J Biomed Mater Res B Appl Biomater. 2018 106(8):2827-2840
Chen F, Ni Y, Liu B, Zhou T, Yu C, Su Y, Zhu X, Yu X （通讯作者）, Zhou Y Self-crosslinking and injectable hyaluronic acid/RGD-functionalized pectin hydrogel for cartilage tissue engineering Carbohydr Polym 2017 166:31-44
Zhou W, Yuan T, Gao Y, Yin P, Liu W, Pan C, Liu Y, Yu X （通讯作者） IL-1β-induces NF-κB and upregulates microRNA-372 to inhibit spinal cord injury recovery J Neurophysiol 2017 117(6):2282-2291
Wang N, Wang F, Gao Y, Zhou Z, Liu W, Pan C, Yin P, Tang M, Yu X （通讯作者） Solanum Muricatum Promotes Osteogenic Differentiation of Rat Bone Marrow Stromal Cells J Food Sci 2017 82(7):1775-1780
Zhou Z, Pan C, Lu Y, Gao Y, Liu W, Yin P, Yu X （通讯作者） Combination of Erythromycin and Curcumin Alleviates Staphylococcus aureus Induced Osteomyelitis in Rats Front Cell Infect Microbiol 2017 7:379
Wang F, Wang N, Gao Y, Zhou Z, Liu W, Pan C, Yin P, Yu X （通讯作者）, Tang M β-Carotene suppresses osteoclastogenesis and bone resorption by suppressing NF-κB signaling pathway Life Sci 2017 174:15-20
Wang F, Guan X, Wu T, Qiao J, Han Z, Wu J, Yu X （通讯作者）, You Q Acellular Endocardium as a Novel Biomaterial for the Intima of Tissue-Engineered Small-Caliber Vascular Grafts Artif Organs 2016 40(12):E253-E265
Wang N, Zhou Z, Wu T, Liu W, Yin P, Pan C, Yu X （通讯作者） TNF-α-induced NF-κB activation upregulates microRNA-150-3p and inhibits osteogenesis of mesenchymal stem cells by targeting β-catenin Open Biol 2016 6(3). pii: 150258
Chen C, Lu J, Yu Q, Xiao JR, Wei HF, Song XJ, Ge JB, Tao WD, Qian R, Yu XW （通讯作者）, Zhao J Expression of CDc6 after acute spinal cord injury in adult rats Neuropeptides 2016 56:59-67
Chen F, Yu S, Liu B, Ni Y, Yu C, Su Y, Zhu X, Yu X （通讯作者）, Zhou Y, Yan D An Injectable Enzymatically Crosslinked Carboxymethylated Pullulan/Chondroitin Sulfate Hydrogel for Cartilage Tissue Engineering Sci Rep 2016 6:20014
Zhao J, Chen C, Xiao JR, Wei HF, Zhou XH, Mao XX, Zhang WD, Qian R, Chen XL, He MQ, Yu XW* （通讯作者）, Zhao J An Up-regulation of IRF-1 After a Spinal Cord Injury: Implications for Neuronal Apoptosis J Mol Neurosci 2015 57(4):595-604
Wu T, Zhou Z, Ren W, He Z, Yu X （通讯作者）, Huang Y Reinforcement of A New Calcium Phosphate Cement with RGD-chitosan-fiber J Biomed Mater Res A 2014 102(1): 68-75
Yu XW, Ai ZS, Gao YS, Zhang CQ Blood loss closely correlates with body mass index in total hip arthroplasty performed through direct lateral approach Saudi Med J 2013 34(7):709-13
Yu X, Jiang W, Pan Q, Wu T, Zhang Y, Zhou Z, Du D Umbrella-shaped, memory alloy femoral head support device for treatment of avascular osteonecrosis of the femoral head Int Orthop 2013 37(7):1225-32
Yu X, Wen H, Cao J, Sun B, Ding T, Li M, Wu H, Long L, Cheng X, Xu G, Zhang F Temporal and Spatial Expression of KIF3B after Acute Spinal Cord Injury in Adult Rats J Mol Neurosci 2013 49(2):387-94
Song W, Yu X （通讯作者）, Markel DC, Shi T, Ren W Coaxial PCL/PVA electrospun nanofibers: osseointegration enhancer and controlled drug release device Biofabrication 2013 5(3):035006
Wu T, Zhang Q, Ren W, Yi X, Zhou Z, Peng X, Yu X （通讯作者）, Lang M Controlled release of gentamicin from gelatin/genipin reinforced beta-tricalcium phosphate scaffold for the treatment of osteomyelitis J Mater Chem B 2013 3304-3313
Yu X, Zhao X, Wu T, Zhou Z, Gao Y, Wang X, Zhang CQ Inhibiting wear particles-induced osteolysis with naringin Int Orthop 2013 37(1):137-43
Yu X, Tang M, Zhou Z, Peng X, Wu T, Sun Y Minimally invasive treatment for pubic ramus fracture combined with sacroiliac joint complex injury Int Orthop 2013 37(8):1547-54
Wu T, Hua X, He Z, Wang X, Yu X （通讯作者）, Ren WP The bactericidal and biocompatible characteristics of reinforced calcium phosphate cements Biomed Mater 2012 7(4):045003
Yu X, Zhong Y, Zhu Z, Wu T, Shen A, Huang Y Increased expression of nitric oxide synthase interacting protein (NOSIP) following traumatic spinal cord injury in rats J Mol Histol 2012 43(6):661-8
Zhong Y, Huang Y, Cao J, Lu X, Feng M, Shen G, Shen A, Yu X （通讯作者） Increase in phosphorylation of PDK1 and cell survival after acute spinal cord injury J Neurol Sci 2012 320(1-2):38-44
Xie XH, Yu XW （共同第一作者）, Zeng SX, Du RL, Hu YH, Yuan Z, Lu EY, Dai KR, Tang TT Enhanced osteointegration of orthopaedic implant gradient coating composed of bioactive glass and nanohydroxyapatite J Mater Sci Mater Med 2010 21(7):2165-73
Yu XW, Xie XH, Yu ZF, Tang TT Augmentation of Screw Fixation with Injectable Calcium Sulfate Bone Cement in Ovariectomized Rats J Biomed Mater Res B Appl Biomater 2009 89(1):36-44