导师姓名： 何耀华 专业代码： 100210
性别： 男 专业名称： 外科学
培养单位： 附属第六人民医院 三级学科/
专业领域： 骨外
导师类型： 博士生导师 专业学位导师： 兼
联系方式：
邮编： 200233 邮箱地址： heyaohua@vip.163.com

研究方向 (点击浏览详细信息)
肩关节疾病诊治；腱骨愈合；骨软骨损伤修复

社会任职
中国医师协会肩肘外科学组委员
上海医师协会运动医学分会肩肘外科学组委员兼副组长
中华医学会运动医学分会肩肘外科上肢学组委员
上海市医学会运动医学学组委员
SICOT中国部肩肘外科学会委员
APKASS会员
美国ISAKOS会员
《中华临床医师杂志》特邀编委
《中华骨与关节外科杂志》编委
《中华肩肘外科电子杂志》编委

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
19XD** 有机磷源合成不同形貌特征磷酸钙/胶原复合支架的成骨活性及其机制研究 上海市科学技术委员会 2019-05~2022-04 40万元 课题负责人
** 富含腺苷的磷酸钙纳米球/胶原复合生物活性支架促进骨与血管再生修复大段骨缺损的分子机制 国家自然基金面上项目 2019-01~2022-12 57万元 课题负责人
LY33.2029 生物活性材料促进骨修复及其机理研究 上海市第六人民医院双聘PI创新团队项目 2017-01~2020-12 100万元 课题负责人
** 镁合金经TRPM7激活PI3K/Akt通路调节p21-CDKs表达促进软骨细胞增殖的分子机制 国家自然基金面上项目 2016-01~2019-12 57万元 课题负责人
SS2015AA020316 引导组织再生的新型体温响应智能水凝胶复合体系和产品研发 国家高技术研究发展计划(863计划) 2015-01~2017-12 60万元 子课题负责人
**/H0604 镁合金支架复合基因修饰的BMSCs构建关节软骨及修复软骨缺损的作用 国家自然基金面上项目 2013-01~2016-12 70万元 课题负责人
**/H0604 β-TCP涂层镁合金支架复合BMSC构建新骨和修复骨缺损的作用 国家自然基金面上项目 2011-01~2013-12 32万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Chongyang Wang, Qingxiang Hu, Wei Song, Weilin Yu, Yaohua He （通讯作者） Adipose Stem Cell-Derived Exosomes Decrease Fatty Infiltration and Enhance Rotator Cuff Healing in a Rabbit Model of Chronic Tears Am J Sports Med 2020 48(6): 1456-1464
Zhijie Ma,Wei Song,Yaohua He （通讯作者）,Haiyan Li Multilayer Injectable Hydrogel System Sequentially Delivers Bioactive Substances for Each Wound Healing Stage ACS Appl Mater Interfaces 2020 12:29797-29806
Wei Song, Zhijie Ma, Chongyang Wang, Haiyan Li,Yaohua He （通讯作者） Pro-chondrogenic and immunomodulatory melatonin-loaded electrospun membranes for tendon-to-bone healing J Mater Chem B 2019 7(42): 6564-6575
Qi Zhu, Zhijie Ma, Haiyan Li, Haiming Wang, Yaohua He （通讯作者） Enhancement of rotator cuff tendon–bone healing using combined aligned electrospun fibrous membranes and kartogenin RSC Advances 2019 9,15582
Chongyang Wang, Wei Song, Bi Chen, Xudong Liu, Yaohua He （通讯作者） Exosomes Isolated From Adipose-Derived Stem Cells A New Cell-Free Approach to Prevent the Muscle Degeneration Associated With Torn Rotator Cuffs Am J Sports Med 2019 47(13): 3247-3255
Zhu, L. Kong, F. Farhadi, W. Xia, J. Chang, Y. He （通讯作者）, H. Li An injectable continuous stratified structurally and functionally biomimetic construct for enhancing osteochondral regeneration Biomaterials 2019 192: 149-158
Kong, Z. Wu, H. Zhao, H. Cui, J. Shen, J. Chang, H. Li, Y. He （通讯作者） Bioactive Injectable Hydrogels Containing Desferrioxamine and Bioglass for Diabetic Wound Healing ACS Appl Mater Interfaces 2018 10(36): 30103-30114
Q. Hu, Z. Ding, H. Zhang, Y. He （通讯作者） The Superior Glenohumeral Joint Capsule Alone Does Not Prevent Superior Translation of the Humeral Head: An In Vitro Biomechanical Study Arthroscopy 2018 34(11): 2962-2970
You X, Y. Shen, W. Yu, Y. He （通讯作者） Enhancement of tendonbone healing following rotator cuff repair using hydroxyapatite with TGFbeta1 Mol Med Rep 2018 17(4): 4981-4988
Sun TW, Yu WL, Zhu YJ, Chen F, Zhang YG, Jiang YY, He YH. （通讯作者） Porous Nanocomposite Comprising Ultralong Hydroxyapatite Nanowires Decorated with Zinc-Containing Nanoparticles and Chitosan: Synthesis and Application in Bone Defect Repair. Chemistry 2018 24(35):8809-8821
Qiu M, Chen D, Shen C, Shen J, Zhao H, He Y*. （通讯作者） Preparation of in situ forming and injectable alginate/mesoporous Sr-containing calcium silicate composite cement for bone repair RSC Adv 2017 7: 23671-79
Yu W, Sun T, Qi C, Ding Z, Zhao H, Chen F, Chen D, Zhu Y, Shi Z, He Y*. （通讯作者） Strontium-Doped Amorphous Calcium Phosphate Porous Microspheres Synthesized through a Microwave-Hydrothermal Method Using Fructose 1,6-Bisphosphate as an Organic Phosphorus Source: Application in Drug Delivery and Enhanced Bone Regeneration ACS Appl Mater Interfaces 2017 9(4):3306-17
Yu W, Zhao H, Ding Z, Zhang Z, Sun B, Shen J, Chen S, Zhang B, Yang K, Liu M, Chen D, He Y*. （通讯作者） In vitro and in vivo evaluation of MgF2 coated AZ31 magnesium alloy porous scaffolds for bone regeneration. Colloids Surf B Biointerfaces 2017 149(1): 330-40
Yu W, Sun T, Qi C, Zhao H, Ding Z, Zhang Z, Sun B, Shen J, Chen F, Zhu Y, Chen D, He Y*. （通讯作者） Enhanced osteogenesis and angiogenesis by mesoporous hydroxyapatite microspheres-derived simvastatin sustained release system for superior bone regeneration. Sci Rep 2017 7:44129
Yu W, Sun T, Qi C, Ding Z, Zhao H, Zhao S, Shi Z, Zhu Y, Chen D, He Y*. （通讯作者） Evaluation of zinc-doped mesoporous hydroxyapatite microspheres for the construction of a novel biomimetic scaffold optimized for bone augmentation. Int J Nanomedicine 2017 12:2293-306
Qiu M, Chen D, Shen C, Shen J, Zhao H, He Y. （通讯作者） Sex-determining region Y-box protein 3 induces epithelial-mesenchymal transition in osteosarcoma cells via transcriptional activation of Snail1. J Exp Clin Cancer Res. 2017 36(1):46.
Yu W, Sun T, Ding Z, Qi C, Zhao H, Chen F, Shi Z, Zhu Y, Chen D, He Y*. （通讯作者） Copper-doped mesoporous hydroxyapatite microspheres synthesized by a microwave-hydrothermal method using creatine phosphate as an organic phosphorus source: application in drug delivery and enhanced bone regeneration J MATER CHEM B 2017 5: 1039-52
Sun TW, Yu WL, Zhu YJ, Yang RL, Shen YQ, Chen DY, He YH （通讯作者）, Chen F. Hydroxyapatite Nanowire@Magnesium Silicate Core-Shell Hierarchical Nanocomposite: Synthesis and Application in Bone Regeneration. ACS Appl Mater Interfaces 2017 9(19):16435-16447
Qiu M, Chen D, Shen C, Shen J, Zhao H, He Y*. （通讯作者） Platelet-Rich Plasma-Loaded Poly(d,l-lactide)-Poly(ethylene glycol)-Poly(d,l-lactide) Hydrogel Dressing Promotes Full-Thickness Skin Wound Healing in a Rodent Model. Int J Mol Sci 2016 17(7):1001
Qiu M, Wang C, Chen D, Shen C, Zhao H, He Y*. （通讯作者） Angiogenic and Osteogenic Coupling Effects of Deferoxamine-Loaded Poly(lactide-co-glycolide)-Poly(ethylene glycol)-Poly(lactide-co-glycolide) Nanoparticles. Appl Sci 2016 6(10): 290
Yu, W.; Chen, D.; Ding, Z.; Qiu, M.; Zhang, Z.; Shen, J.; Zhang, X.; Zhang, S.; He （通讯作者）, Y.; Shi, Z. Synergistic effect of a biodegradable Mg–Zn alloy on osteogenic activity and anti-biofilm ability: an in vitro and in vivo study Rsc Advances 2016 6 (51):45219-45230
Yu, W.; Jiang, Y. Y.; Sun, T. W.; Qi, C.; Zhao, H.; Chen, F.; Shi, Z.; Zhu, Y. J.; Chen, D.; He （通讯作者）, Y. Design of a novel wound dressing consisting of alginate hydrogel and simvastatin-incorporated mesoporous hydroxyapatite microspheres for cutaneous wound healing RSC Advances 2016 6(106):104375-104387