导师姓名： 张先龙 专业代码： 100210
性别： 男 专业名称： 外科学
培养单位： 附属第六人民医院 三级学科/
专业领域： 骨外
导师类型： 博士生导师 专业学位导师： 兼
联系方式： 秘书：董老师 **@qq.com
邮编： 200233 邮箱地址： @qq.com

研究方向 (点击浏览详细信息)
关节疾病及人工关节置换的基础与临床

社会任职
世界华裔骨科学会理事
《中华老年骨科与康复电子杂志》特约编委
《中华骨科杂志》编委
《中华解剖与临床杂志》副总编辑，JOA中文版副总编辑
中国医师协会骨科医师分会委员、关节工作委员会副主委、中国人工关节感染专业委员会（PJI）主任委员
《中国骨与关节杂志》常务编委
中国医师协会机器人外科医师分会医用机器人分会常委
SICOT中国部关节外科学会副主任委员
亚太人工关节学会（ASIA）中国分会理事
《中华医学杂志》英文版（CMJ）编委
《中国矫形外科杂志》编委
世界华裔骨科学会理事
上海医学会骨科专科分会关节外科学组组长
中国研究型医院学会关节外科学专业委员会人工关节表界面材料研究学组（CASIS）组长
《Arthroplasty》副主编
《中华外科杂志》编委
ASIA人工关节感染共识编委会主任委员
中华医学会骨科学分会关节外科学组副组长
《中华关节外科杂志》（电子版）副总编辑

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
免疫调控具有多重生物学效应的聚醚醚酮骨内植物构建及其机制研究 国自然面上项目 2020-01~2023-12 56万元 课题负责人
** 多级修饰具有表面多孔结构的双活性低模量钛的制备及其生物学研究 国自然面上项目 2018-01~2021-12 58万元 课题负责人
/ 院级优势特色专业 上海市第六人民医院 2016-03~2017-12 14.48万元 课题负责人
** 小鼠β-防御素-14调节机体获得性免疫应答抑制生物膜感染的实验研究 国家自然基金面上项目 2015-01~2018-12 80万元 课题负责人
** 新型医用低模量钛合金及其表面Ag纳米管的制备和生物学基础研究 国家自然基金面上项目 2013-01~2016-12 70万元 课题负责人
** 以 TAK1 信号传导通路为靶点抑制假体周围骨溶解的实验 国家自然基金面上项目 2012-01~2015-12 58万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Jinhua Li#,Wei Liu#,David Kilian,Xianlong Zhang* （通讯作者）,Michael Gelinsky,Paul K. Chu* Bioinspired interface design modulates pathogen and immunocyte responses in biomaterialcentered infection combination therapy Materials Horizons 2019 2019, 6, 1271--1282
Wei Liu, Jinhua Li, Mengqi Cheng, Qiaojie Wang, Yebin Qian, Kelvin W.K. Yeung*, Paul K. Chu*, Xianlong Zhang* （通讯作者） A surface-engineered polyetheretherketone biomaterial implant with direct and immunoregulatory antibacterial activity against methicillin-resistant Staphylococcus aureus Biomaterials 2019 208 (2019) 8-20
Yuan X, Ouyang L, Luo Y, Sun Z, Yang C, Wang J, Liu X*, Zhang X*. （通讯作者） Multifunctional sulfonated polyetheretherketone coating with beta-defensin-14 for yielding durable and broad-spectrum antibacterial activity and osseointegration Acta Biomater 2019 86:323-337
Jinhua Li#, Wei Liu#, Xianlong Zhang* （通讯作者）, Kelvin W. K*. Yeung, Paul K. Chu*. Temperature-responsive tungsten doped vanadium dioxide thin film starves bacteria to death Materials Today 2019 2019; 22, 35-49
Wei Liu, Desheng Chen, Qiuyan Li, Dong Wang, Mengqi Cheng*, Guo He*,Xianlong Zhang* . （通讯作者） A lithium-containing nanoporous coating on entangled titanium scaffold can enhance osseointegration through Wnt/beta-catenin pathway, Nanomedicine: nanotechnology, biology, and medicine 2018 14(1) (2018) 153-164
Wei Liu, Jinhua Li, Kelvin W. K*. Yeung, Paul K. Chu*, and Xianlong Zhang* . （通讯作者） Zinc-modified sulfonated polyetheretherketone surface with immunomodulatory function for guiding cell fate and bone regeneration Advanced Science 2018 (2018) **
Xiangwei Yuan, Huiliang Cao, Jiaxing Wang, Kaiwei Tang, Bin Li, Yaochao Zhao, Mengqi Cheng, Hui Qin, Xuanyong Liu*, Xianlong Zhang* （通讯作者） Immunomodulatory Effects of Calcium and Strontium Co-Doped Titanium Oxides on Osteogenesis Frontiers in Immunology 2017 8: 1196
Jiaxing Wang, Huaijuan Zhou, Hao Shen*, Jinhua Li*, Xianlong Zhang*. （通讯作者） Enhanced Anti-Infective Efficacy of ZnO Nanoreservoirs through a Combination of Intrinsic Anti-Biofilm Activity and Reinforced Innate Defense. ACS Appl Mater Interfaces 2017 9:33609-33623
Bin Li, Yan Hu, Xianlong Zhang* （通讯作者） Curcumin attenuates titanium particle-induced inflammation by regulating macrophage polarization in vitro and in vivo Frontiers in immunology 2017 2017.8
Jinhua Li, Jiaxing Wang, Xianlong Zhang* （通讯作者）, Xuanyong Liu*. Band Gap Engineering of Titania Film through Cobalt Regulation for Oxidative Damage of Bacterial Respiration and Viability. ACS Appl Mater Interfaces, 2017 9:27475-27490
张先龙 （通讯作者）,沈灏,王加兴. 1.人工关节假体感染诊治的研究进展 中华关节外科杂志(电子版) 2017 11(4): 327-330
Wei Liu, J. Wang, G. Jiang, J. Guo, Q. Li, B. Li, Q. Wang, M. Cheng*, G. He*, Xianlong Zhang* （通讯作者） The improvement of corrosion resistance, biocompatibility and osteogenesis of the novel porous Mg-Nd-Zn alloy Journal of Materials Chemistry B 2017 5(36) (2017) 7661-7674
王俏杰,柴伟,王琦,陈云苏,沈灏,彭晓春,倪明,付君,陈继营,张先龙 （通讯作者） 机器人辅助下膝关节单髁置换术初步临床结果 中华解剖与临床杂志 2016 （22）2:108-115
Wang J, Li J, Qian S, Guo G, Wang Q, Tang J, Shen H*, Liu X*, Zhang X* （通讯作者）, Chu PK Antibacterial Surface Design of Titanium-Based Biomaterials for Enhanced Bacteria-Killing and Cell-Assisting Functions Against Periprosthetic Joint Infection. ACS Appl Mater Interfaces 2016 4;8(17):11162-78
Ouyang L, Zhao Y, Jin G, Lu T, Li J, Qiao Y, Ning C, Zhang X* （通讯作者）, Chu PK, Liu X* Influence of sulfur content on bone formation and antibacterial ability of sulfonated PEEK Biomaterials 2016 83(2016): 15-126
Liu W, Zhang X （通讯作者） Receptor activator of nuclear factor-κB ligand (RANKL)/RANK/osteoprotegerin system in bone and other tissues (review) Mol Med Rep 2015 11(5):3212-8
Zhang Yin, He Wenye, Cheng Tao, Zhang Xian-long （通讯作者） Total hip arthroplasty: leg length discrepancy affects functional outcomes and patient’s gait Cell biochemistry and biophysics 2015 72:1 : 215-219
Zhao Y, Cao H, Qin H, Cheng T, Qian S, Cheng M, Peng X, Wang J, Zhang Y, Jin G, Zhang X （通讯作者）, Liu X, Chu PK Balancing the Osteogenic and Antibacterial Properties of Titanium by Codoping of Mg and Ag: An in Vitro and in Vivo Study ACS Appl Mater Interfaces 2015 19;7(32):17826-36
Zhang Y, Cheng T, Zhang XL （通讯作者） Changes in Intra-pelvic Obliquity Angle 0-2 Years After Total Hip Arthroplasty and Its Effects on Leg Length Discrepancy: A Retrospective Study Chin Med J (Engl) 2015 20;128(10):1346-50
Peng X, Zhang X （通讯作者）, Cheng T, Cheng M, Wang J Comparison of the quadriceps-sparing and subvastus approaches versus the standard parapatellar approach in total knee arthroplasty: a meta-analysis of randomized controlled trials BMC Musculoskelet Disord 2015 31;16(1):327
Fu H, Wang J, Zhang W, Cheng T, Zhang X （通讯作者） No clinical benefit of posterior stabilized high-flex total knee arthroplasty. A meta-analysis of randomized controlled trials J Arthroplasty 2015 30(4):573-9
Qin H, Zhao Y, An Z, Cheng M, Wang Q, Cheng T, Wang Q, Wang J, Jiang Y, Zhang X （通讯作者）, Yuan G Enhanced antibacterial properties, biocompatibility, and corrosion resistance of degradable Mg-Nd-Zn-Zr alloy Biomaterials 2015 53:211-20
Fu H, Wang J, Zhou S, Cheng T, Zhang W, Wang Q, Zhang X （通讯作者） No difference in mechanical alignment and femoral component placement between patient-specific instrumentation and conventional instrumentation in TKA Knee Surg Sports Traumatol Arthrosc 2015 23(11):3288-95.
Qin H, Zhao Y, Cheng M, Wang Q, Wang Q, Wang J, Jiang Y, An Z, Zhang X （通讯作者） Anti-biofilm properties of magnesium metal via alkaline pH Rsc Advances 2015 5 (28),:21434-21444
Wang QJ, Shen H, Zhang XL （通讯作者）,Jiang Y, Wang Q, Chen YS, Shao JJ Staged reimplantation for the treatment of fungal peri-prosthetic joint infection following primary total knee arthroplasty Orthop Traumatol Surg Res 2015 101(2):151-6
Zhang Y, Cheng T, Gao H, Zhang XL （通讯作者） Traumatic diaphragmatic hernia associated with pelvic ring fracture Chin Med J (Engl) 2015 5;128(9):1272-4
Jin G, Qin H, Cao H, Qiao Y, Zhao Y, Peng X, Zhang X （通讯作者）, Liu X, Chu PK. Z. Biomaterials n/Ag micro-galvanic couples formed on titanium and osseointegration effects in the presence of S. aureus Biomaterials 2015 65:22-31
Liu W, Wahafu T, Cheng M, Cheng T, Zhang Y, Zhang X （通讯作者） The influence of obesity on primary total hip arthroplasty outcomes: A meta-analysis of prospective cohort studies Orthop Traumatol Surg Res 2015 101(3):289-96
Qin H, Cao H, Zhao Y, Jin G, Cheng M, Wang J, Jiang Y, An Z, Zhang X （通讯作者）, Liu X. Antimicrobial and osteogenic properties of silver-ion-implanted stainless steel ACS Appl Mater Interfaces 2015 27;7(20):10785-94
Shen H, Tang J, Wang Q, Jiang Y, Zhang X （通讯作者） Sonication of explanted prosthesis combined with incubation in BD bactec bottles for pathogen-based diagnosis of prosthetic joint infection J Clin Microbiol 2015 53(3):777-81
Cheng M, Qiao Y, Wang Q, Jin G, Qin H, Zhao Y, Peng X, Zhang X （通讯作者）, Liu X Calcium Plasma Implanted Titanium Surface with Hierarchical Microstructure for Improving the Bone Formation ACS Appl Mater Interfaces 2015 17;7(23):13053-61
Liu W, Cheng M, Wahafu T, Zhao Y, Qin H, Wang J, Zhang X （通讯作者）, Wang L The in vitro and in vivo performance of a strontium-containing coating on the low-modulus Ti35Nb2Ta3Zr alloy formed by micro-arc oxidation J Mater Sci Mater Med 2015 26(7):203
Xiaochun Peng, Tao Cheng, Mengqi Cheng, Jiaxing Wang, Xianlong Zhang （通讯作者） Hierarchically porous CaCO3 monoliths prepared from leaf template Materials Letters 2014 15; 129(198-201)
Zhu C, Wang J, Cheng T, Li Q, Shen H, Qin H, Cheng M, Zhang X （通讯作者） The potential role of increasing the release of mouse β- defensin-14 in the treatment of osteomyelitis in mice: a primary study PLoS One 2014 28;9(1):e86874
Qin H, Zhu C, An Z, Jiang Y, Zhao Y, Wang J, Liu X （通讯作者）, Hui B, Zhang X, Wang Y Silver nanoparticles promote osteogenic differentiation of human urine-derived stem cells at noncytotoxic concentrations Int J Nanomedicine 2014 20;9:2469-78.
Cheng T, Zhu C, Wang J, Cheng M, Peng X, Wang Q, Zhang X （通讯作者） No clinical benefit of gender-specific total knee arthroplasty Acta Orthop 2014 85(4):415-21
Jin G, Qin H, Cao H, Qian S, Zhao Y, Peng X, Zhang X （通讯作者）, Liu X, Chu PK Synergistic effects of dual Zn/Ag ion implantation in osteogenic activity and antibacterial ability of titanium Biomaterials 2014 35(27):7699-713
Qin H, Cao H, Zhao Y, Zhu C, Cheng T, Wang Q, Peng X, Cheng M, Wang J, Jin G, Jiang Y, Zhang X （通讯作者）, Liu X, Chu PK In vitro and in vivo anti-biofilm effects of silver nanoparticles immobilized on titanium Biomaterials 2014 35(33):9114-25
Shen H, Tang J, Mao Y, Wang Q, Wang J, Zhang X, Jiang Y （通讯作者） Pathogenic analysis in different types of orthopedic implant infections Chin Med J (Engl) 2014 127(15):2748-52
Zhu C, Tan H, Cheng T, Shen H, Shao J, Guo Y, Shi S, Zhang X （通讯作者） Human β-defensin 3 inhibits antibiotic-resistant Staphylococcus biofilm formation J Surg Res 2013 183(1):204-13
Wang J, Zhu C, Cheng T, Peng X, Zhang W, Qin H, Zhang X （通讯作者） A systematic review and meta-analysis of antibiotic-impregnated bone cement use in primary total hip or knee arthroplasty PLoS One 2013 12;8(12):e82745
Guo Y, Chen D, Cheng M, Lu W, Wang L, Zhang X （通讯作者） The bone tissue compatibility of a new Ti35Nb2Ta3Zr alloy with a low Young's modulus Int J Mol Med 2013 31(3):689-97.
Guo Y, Chen D, Lu W, Jia Y, Wang L, Zhang X... （通讯作者） Corrosion resistance and in vitro response of a novel Ti35Nb2Ta3Zr alloy with a low Young's modulus Biomed Mater 2013 8(5):055004
Shi S, Zhang X （通讯作者） Adjunctive use of rifampicin pre-operation can reduce infections in orthopaedic surgery Scand J Infect Dis 2013 45(4):334-5
Cheng M, Chen D, Guo Y, Zhu C, Zhang X （通讯作者） Comparison of fixed- and mobile-bearing total knee arthroplasty with a mean five-year follow-up: A meta-analysis Exp Ther Med 2013 6(1):45-51
Cheng T, Chen D, Zhu C, Pan X, Mao X, Guo Y, Zhang X （通讯作者） Fixed- versus mobile-bearing unicondylar knee arthroplasty: are failure modes different Knee Surg Sports Traumatol Arthrosc 2013 21(11):2433-41
Zhu C, Tan H, Cheng T, Shen H, Shao J, Guo Y, Shi S, Zhang X. （通讯作者） Human β-defensin 3 inhibits antibiotic-resistant Staphylococcus biofilm formation J Surg Res 2013 183(1):204-13.
Zhu C, Cheng MQ, Cheng T, Ma RX, Kong R, Guo YY, Qin H, Shi SF, Zhang XL （通讯作者） A novel classification to guide total hip arthroplasty for adult acetabular dysplasia Exp Ther Med 2013 6(1): 216-222
Zhu C, Qin H, Cheng T, Tan HL, Guo YY, Shi SF, Chen DS, Zhang XL （通讯作者） Staphylococcus aureus supernatant induces the release of mouse beta-defensin-14 from osteoblasts via the p38 MAPK and NF-kappaB pathways Int J Mol Med 2013 31(6): 1484-1494
Shao JJ, Parker Vail T, Wang QJ, Shen H, Chen YS, Wang Q, Jiang Y, Zhang XL （通讯作者） Anatomical references for tibial sagittal alignment in total knee arthroplasty: a comparison of three anatomical axes based on 3D reconstructed CT images Chin Med J (Engl) 2013 126(20): 3840-3844
Qin H, Hu C Z, Zhang X L （通讯作者）, et al Surgical treatment of Ideberg type III glenoid fractures with associated superior shoulder suspensory complex injury Orthopedics 2013 36(10): e1244-e1250
Shi SF, Jia JF, Guo XK, Zhao YP, Chen DS, Guo YY, Cheng T, Zhang XL （通讯作者） Biocompatibility of chitosan-coated iron oxide nanoparticles with osteoblast cells. Int J Nanomedicine 2012 7:5593-602
Zhang XL, Zhang W, Shao JJ Rotational alignment in total knee arthroplasty: nonimage-based navigation system versus conventional technique. Chin Med J (Engl) 2012 125(2):236-43
Mao X, Pan X, Zhao S, Peng X, Cheng T, Zhang X （通讯作者） Protection against titanium particle-induced inflammatory osteolysis by the proteasome inhibitor bortezomib in vivo. Inflammation 2012 35(4):1378-91
Mao X, Pan X, Peng X, Cheng T, Zhang X （通讯作者） Inhibition of titanium particle-induced inflammation by the proteasome inhibitor bortezomib in murine macrophage-like RAW 264.7 cells Inflammation 2012 35(4):1411-8
Pan X, Zhang X （通讯作者）, Liu Z, Wen H, Mao X Treatment for chronic synovitis of knee: arthroscopic or open synovectomy. Rheumatol Int 2012 32(6):1733-6
Pan X, Mao X, Cheng T, Peng X, Zhang X （通讯作者）, Liu Z, Wang Q, Chen Y Up-regulated expression of MIF by interfacial membrane fibroblasts and macrophages around aseptically loosened implants. J Surg Res 2012 176(2):484-9
Wang Q, Zhang XL （通讯作者）, Chen YS, Shen H, Shao JJ Resurfacing arthroplasty for hip dysplasia: a prospective randomised study. J Bone Joint Surg Br 2012 94B(6):768-73
Mao X, Pan X, Cheng T, Zhang X （通讯作者） Therapeutic potential of the proteasome inhibitor Bortezomib on titanium particle-induced inflammation in a murine model. Inflammation 2012 35(3):905-12
Zhang W, Zhao H, Peng X, Cheng T, Zhang X （通讯作者） Low-dose captopril inhibits wear debris-induced inflammatory osteolysis. J Int Med Res 2011 39(3):798-804
Zhang W, Peng X, Cheng T, Zhang X （通讯作者） Vascular endothelial growth factor gene silencing suppresses wear debris-induced inflammation. Int Orthop 2011 35(12):1883-8
Ning R, Zhang X （通讯作者）, Guo X, Li Q Staphylococcus aureus regulates secretion of interleukin-6 and monocyte chemoattractant protein-1 through activation of nuclear factor kappaB signaling pathway in human osteoblasts. Braz J Infect Dis 2011 15(3):189-94
Pan X, Mao X, Cheng T, Zhang X （通讯作者） Macrophage migration inhibitory factor: a regulator of MMP13 and inflammation in titanium particles-stimulated air pouch in vivo. Mol Cell Biochem 2011 357(1-2):313-21
Liu X, Zhang X （通讯作者）, Chen Y, Wang Q, Jiang Y, Zeng B Hidden Blood Loss After Total Hip Arthroplasty. J Arthroplasty 2011 26(7):1100-5
Ning R, Zhang X （通讯作者）, Guo X, Li Q Attachment of Staphylococcus aureus is required for activation of nuclear factor kappa B in human osteoblasts. Acta Biochim Biophys Sin (Shanghai) 2010 42(12):883-92
Hu K, Wang C, Zhang X （通讯作者） High pressure may inhibit periprosthetic osteogenesis. J Bone Miner Metab 2010 28(3):289-98