导师姓名： 张正筠 专业代码： 100210
性别： 男 专业名称： 外科学
培养单位： 附属第六人民医院 三级学科/
专业领域： 普外
导师类型： 硕士生导师 专业学位导师： 兼
联系方式： E-mail：zhengyunzh@sina.cn
邮编： 200233 邮箱地址： zhengyunzh@sina.cn

研究方向 (点击浏览详细信息)
原发性及转移性肝脏恶性肿瘤的临床和基础

社会任职
中国研究型医院学会加速康复外科专业委员会胆道学组委员
中国医师协会外科医师分会胆道外科医师委员会青年委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** microRNA-191调控O-Glc-NAc糖基化在合并糖尿病的肝内胆管细胞癌中的作用机制研究 国家自然科学基金 2020-01~2023-12 56万元 课题负责人
** SIRT1通过HIF-1α调控p53突变型肝癌瓦伯格效应的作用及分子机制的研究 国家自然科学基金 2016-01~2018-12 18万元 课题负责人
14PJ** SIRT1 调控p53 突变型肝细胞肝癌生长的机制研究 上海市浦江人才计划 2014-07~2016-06 20万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Jiao Guan, Zun-Qiang Zhou, Mao-Hua Chen, Hui-Yan Li, Da-Nian Tong, Jun Yang, Jing Yao, Zheng-Yun Zhang （通讯作者） Folate-conjugated and pH-responsive polymeric micelles for target-cellspecific anticancer drug delivery Acta Biomater 2017 60: 244-255
Zun-Qiang Zhou, Da-Nian Tong, Jiao Guan, Mei-Fang Li, Qi-Ming Feng, Min-Jie Zhou, Zheng-Yun Zhang （通讯作者） Circulating follicular helper T cells presented distinctively different responses toward bacterial antigens in primary biliary cholangitis Int Immunopharmacol 2017 51: 76-81
Hao Li, Zun-Qiang Zhou, Zhang-Ru Yang, Da-Nian Tong, Jiao Guan, Bao-Jie Shi, Jia Nie, Xian-Ting Ding, Bin Li, Guang-Wen Zhou, Zheng-Yun Zhang （通讯作者） MicroRNA-191 Acts as a Tumor Promoter by Modulating the TET1–p53 Pathway in Intrahepatic Cholangiocarcinoma Hepatology 2017 66 (1):136-151
Zheng-Yun Zhang, Jiao Guan, Hao Li, Zun-Qiang Zhou, Guang-Wen Zhou Heme Oxygenase-1 Promoter Polymorphism Protects Liver Allograft Indian J Surg 2016 78 (1): 14-19
Zun-Qiang Zhou, Da-Nian Tong, Jiao Guan, Hung-Wu Tan, Lu-Don Zhao, Ying Zhu, Jing Yao, Jun Yang, Zheng-Yun Zhang （通讯作者） Follicular helper T cell exhaustion induced by PD-L1 expression in hepatocellular carcinoma results in impaired cytokine expression and B cell help, and is associated with advanced tumor stages Am J Transl Res 2016 8 (7): 2926-2936
Zheng-Yun Zhang, Rui Chen, Zun-Qiang Zhou, Cheng-Hong Peng, Guang-Wen Zhou Prognostic Evaluation of Patients Undergoing Living-Donor Liver Transplant By APACHE II and MELD Scores Exp Clin?Transplant 2015 13 (1)：41-45
Zheng Yun Zhang, Doopyo Hong, Seung Hoon Nam, Jong Man Kim, Yong Han Paik, Jae Won Joh, Choon Hyuck David Kwon, Jae Berm Park, Gyu-Seong Choi, Kyu Yun Jang, Cheol Keun Park, Sung Joo Kim SIRT1 regulates oncogenesis via a mutant p53-dependent pathway in hepatocellular carcinoma J Hepatol 2015 62 (2): 121-130
Zheng-Yun Zhang, Zun-Qiang Zhou, Guang-Wen Zhou Higher efficacy of antiviral therapy after major hepatectomy in patients with hepatitis B virus-related hepatocellular carcinoma of less than 3 cm Eur J Gastroenterol Hepatol 2014 26 (10): 1115-1142
Z-Y Zhang, Z-Q Zhou, K-B Song, S-C Kim, G-W Zhou Hepatic stellate cells induce immunotolerance of islet allografts Transplant Proc 2014 46 (5): 1594-1600
heng-Yun Zhang, Zun-Qiang Zhou, Guang-Wen Zhou Outcomes of surgical approaches for gastric cancer with portal hypertension Eur J Gastroenterol Hepatol 2014 26 (12)1: 348-1352
Zhengyun Zhang, Luqin Bian, Yoonho Choi Serum Uric Acid: A Marker of Metabolic Syndrome and Subclinical Atherosclerosis in Korean Men Angiology 2012 63 (6): 420-428
Zheng-Yun Zhang, Lu-Qin Bian, Sung-Joo Kim, Cai-Cun Zhou, Yoon-Ho Choi Inverse Relation of Total Serum Bilirubin to Coronary Artery Calcification Score Detected by Multidetector Computed Tomography in Males Clin Cardiol 2012 35 (5): 301-305
Zhang ZY, Bian LQ, Jae SY, Sung JD, Choi YH Serum total bilirubin is inversely associated with brachial-ankle pulse wave velocity in men with hypertension Heart Vessels 2012 28 (4): 453-460
Zheng-yun Zhang, Rui Zhang, Lin Wang, Chuan Shen, Ji-qi Yan, Yong-jun Chen, Qin-yu Li, Wei-ping Yang, Cheng-hong Peng, Hong-wei Li, Guang-wen Zhou Diagnosis and treatment of pancreatic somatostatinoma: a case report Chin Med J (Engl) 2008 121(22): 2363-2365