导师姓名： 汪泱 专业代码： 100210
性别： 女 专业名称： 外科学
培养单位： 附属第六人民医院 三级学科/
专业领域： 骨外
导师类型： 博士生导师 专业学位导师：
联系方式：
邮编： 200233 邮箱地址： wangy63cn@126.com

研究方向 (点击浏览详细信息)
干细胞及其外泌体与组织器官再生的基础与应用研究

社会任职

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
ZH2018ZDA20 Diels-Alder反应构建的可注射透明质酸水凝胶干细胞外泌体控释材料修复关节软骨损伤的研究 上海交通大学医工交叉重点项目 2019-01~2021-12 100万元 课题负责人
** 胚胎干细胞来源的外泌体调控BMSC的命运防治骨质疏松的作用与机制 国家自然科学基金 2019-01~2022-12 70万元 课题负责人
** IPS-MSC来源的Exosome促进软骨组织再生修复的分子机理 国家自然科学基金 2017-01~2020-12 72万元 课题负责人
** 生物工程化iPS-MSCs来源的外泌体修复缺血性组织损伤的作用及机制 国家自然科学基金 2015-01~2018-12 72万元 课题负责人
** 利用患者特异iPS细胞模型研究多囊肾病的microRNA调控机制 国家自然科学基金 2012-01~2015-12 65万元 课题负责人
2011ZX09102-010-01 基于诱导多能干细胞的重大疾病药物开发和治疗技术平台 国家科技重大专项“重大新药创制”子课题 2011-01~2013-12 75万元 子课题负责人
** 人类诱导多能干细胞（iPS）向肾脏细胞分化及对肾损伤的修复作用 国家自然科学基金 2010-01~2012-12 24万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Bi Chen, Yongjin Sun, Juntao Zhang, Qingwei Zhu, Yunlong Yang, Xin Niu, Zhifeng Deng, Qing Li and Yang Wang Human embryonic stem cell-derived exosomes promote pressure ulcer healing in aged mice by rejuvenating senescent endothelial cells Stem Cell Research &Therapy 2019 10:142
ingwei Zhu, Xiaozheng Ling, Yunlong Yang, Juntao Zhang, Qing Li, Xin Niu,Guowen Hu, Bi Chen, Haiyan Li, Yang Wang （通讯作者）,* and Zhifeng Deng* Embryonic Stem Cells-Derived Exosomes Endowed with Targeting Properties as Chemotherapeutics Delivery Vehicles for Glioblastoma Therapy Adv. Sci. 2019 **
Ruoyu Wu, Chengsheng Huang1, Qingkai Wu1, Xiang Jia, Mengyu Liu1, Zhuowei Xue, Yu Qiu, Xin Niu and Yang Wang Exosomes secreted by urine-derived stem cells improve stress urinary incontinence by promoting repair of pubococcygeus muscle injury in rats Stem Cell Research &Therapy 2019 10:80
LiuX,YangY, LiY, NiuX, ZhaoB, WangY （通讯作者）, Bao, C., Xie, Z., Lin, Q. , Zhu, L. Integration of stem cell-derived exosomes with in situ hydrogel glue as a promising tissue patch for articular cartilage regeneration Nanoscale 2017 9 (13)： 4430-4438
Zhu, Y.; Wang, Y.; Zhao, B.; Niu, X.; Hu, B.; Li, Q.; Zhang, J.; Ding, J.; Chen, Y. ; WangY （通讯作者）, Comparison of exosomes secreted by induced pluripotent stem cell-derived mesenchymal stem cells and synovial membrane-derived mesenchymal stem cells for the treatment of osteoarthritis Stem Cell Research &Therapy 2017 8 (1)： 64
LiuX.,YangY., NiuX., LinQ., ZhaoB. , Wang Y. （通讯作者）,ZhuL. An in situ photocrosslinkable platelet rich plasma–Complexed hydrogel glue with growth factor controlled release ability to promote cartilage defect repair Acta Biomaterialia 2017 5：1742-7061
ChenB.,Li Q.,Zhao B., Wang Y （通讯作者） Stem Cell-Derived Extracellular Vesicles as a Novel Potential Therapeutic Tool for Tissue Repair Stem Cells Translational Medicine 2017 10.1002/sctm.16-0477.
Liu, X.; Li, Q.; Niu, X.; Hu, B.; Chen, S.; Song, W.; Ding, J.; Zhang, C.; Wang （通讯作者）, Y. Exosomes Secreted from Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Prevent Osteonecrosis of the Femoral Head by Promoting Angiogenesis International Journal of Biological Sciences 2017 13 (2)：232
Yunlong Yang, Jieyuan Zhang, Zhenzhen Liu, Qiuning Lin, Xiaolin Liu, Chunyan Bao,Yang Wang （通讯作者）,* Linyong Zhu* Tissue-Integratable and Biocompatible Photogelation by the Imine Crosslinking Reaction Advanced Materials 2016 28(14):2724-30
Qing Li1, Bin Hu1,Guo-wen Hu, Chun-yuanChen, Xin Niu, Juan Liu, Shu-minZhou1,Chang-qingZhang, YangWang* （通讯作者）,Zhi-Feng Deng* tRNA-Derived Small Non-Coding RNAs in Response to Ischemia Inhibit Angiogenesis Scientific Report 2016 6:20850
Zhen-zhen Jiang, Yu-mei Liu, Xin Niu, Jian-yong Yin1, Bin Hu, Shang-chun Guo, Ying Fan, Yang Wang* andNian-song Wang* （通讯作者） Exosomes secreted by human urine-derived stem cells could prevent kidney complications from type I diabetes in rats Stem cell Reserch & therapy 2016 7:24
Zhang J, Liu X, Li H, Chen C, Hu B, Niu X, Li Q, Zhao B, Xie Z, Wang Y. （通讯作者） Exosomes/tricalcium phosphate combination scaffolds can enhance bone regeneration by activating the PI3K/Akt signaling pathway Stem Cell Res Ther. 2016 7(1):136
Zhang J, Yang Y, Chen Y, Liu X, Guo S, Zhu L, Wang Y. （通讯作者） An in situ phototriggered-imine-crosslink composite hydrogel for bone defect repair J. Mater. Chem. B 2016 4,973-981
Guo-wen Hu, Qing Li, Xin Niu, Bin Hu, Juan Liu, Shu-min Zhou, Shang-chun Guo, Hai-li Lang,Chang-qing Zhang, Yang Wang* and Zhi-feng Deng* （通讯作者） Exosomes secreted by human-induced pluripotent stem cell-derived mesenchymal stem cells attenuate limb ischemia by promoting angiogenesis in mice Stem Cell Research & Therapy 2015 6:10
Guan J, Zhang J, Li H, Zhu Z, Guo S, Niu X, Wang Y* （通讯作者）, Zhang C* Human Urine Derived Stem Cells in Combination with β-TCP Can Be Applied for Bone Regeneration PLoS One 2015 10(5):e**
Zhang J, Guan J, Niu X, Hu G, Guo S, Li Q, Xie Z, Zhang C*, Wang Y* （通讯作者） Exosomes released from human induced pluripotent stem cells-derived MSCs facilitate cutaneous wound healing by promoting collagen synthesis and angiogenesis J Trans Med 2015 13:49
Li Q, Tian SF, Guo Y, Niu X, Hu B, Guo SC, Wang NS, Wang Y. （通讯作者） Transplantation of induced pluripotent stem cell-derived renal stem cells improved acute kidney injury. Cell Biosci. 2015 5:45.
Guan J, Zhang J, Guo S, Zhu H, Zhu Z, Li H, Wang Y* （通讯作者）, Zhang C*, Chang J Human urine-derived stem cells can be induced into osteogenic lineage by silicate bioceramics via activation of the Wnt/β-catenin signaling pathway Biomaterials 2015 55:1-11
Xiaolin Liu, Qing Li, Jiagen Sheng, Bin Hu, Zhenzhong Zhu,Shumin Zhou, Junhui Yin, Qiang Gong, Yang Wang （通讯作者）, Changqing Zhang A unique plasma metabolomic signature of osteonecrosis of the femoral head Journal of orthopaedic research 2015 12:33-43
Ji Liu, Huarong Nie, Zhengliang Xu, Fei Guo,Shangchun Guo, Junhui Yin,Yang Wang* and Changqing Zhang* （通讯作者） The construction of PRP-containing nanofibrous scaffolds for controlled release and their application to cartilage regeneration. Journal of Materials Chemistry B 2015 3, 581–591
Zhu H, Cheng X, Niu X, Zhang Y, Guan J, Liu X, Tao S, Wang Y* （通讯作者）, Zhang C* Proton-sensing GPCR-YAP Signalling Promotes Cell Proliferation and Survival Int J Biol Sci 2015 (10):1181-9
Guan J, Zhang J, Zhu Z, Niu X, Guo S, Wang Y*, Zhang C* Bone morphogenetic protein 2 gene transduction enhances the osteogenic potential of human urine-derived stem cells Stem Cell Res Ther 2015 6:5
Yinxin Fu, Junjie Guan, Shangchun Guo, Fei Guo, Xin Niu, Qiang Liu, Changqing Zhang, Hua rong Nie,Yang Wang* （通讯作者） Human urine-derived stem cells in combination with polycaprolactone/gelatin nanofibrous membranes enhance wound healing by promoting angiogenesis J Transl Med 2014 12(1): 274
hui Qin, chenZhu, Zhiquan an,Yao Jiang, Yaochao Zhao,Jiaxin Wang, Xin liu, Bing hui, Xianlong Zhang, Yang Wang* （通讯作者） Silver nanoparticles promote osteogenic differentiation of human urine-derived stem cells at noncytotoxic concentrations Int J Nanomedicine 2014 9: 2469-2478
ChunYuan Chen, Wei Liao, YuanLei Lou, Qing Li, Bin Hu, Yang Wang* （通讯作者）, ZhiFeng Deng* Inhibition of Notch signaling facilitates the differentiation of human-induced pluripotent stem cells into neural stem cells Mol Cell Biochem 2014 395(1-2): 291-298
Ji Liu, Huarong Nie, Zhengliang Xu, Xin Niu, Shangchun Guo, Junhui Yin, Fei Guo, Gang Li,Yang Wang* （通讯作者）, Changqing Zhang* The Effect of 3D Nanofibrous Scaffolds on the Chondrogenesis of Induced Pluripotent Stem Cells and Their Application in Restoration of Cartilage Defects PLoS One 2014 9(11): e111566
JunJie Guan, Xin Niu, FeiXiang Gong, Bin Hu, ShangChun Guo,YuanLei Lou,ChangQing Zhang, ZhiFeng Deng, Yang Wang*. （通讯作者） Biological characteristics of human-urine-derived stem cells: potential for cell-based therapy in neurology Tissue Eng Part A 2014 20(13-14): 1794-1806.
Zhenzhong Zhu, Junhui Yin, Jun jie Guan, Bin Hu, Xin Niu, Dongxu Jin, Yang Wang* （通讯作者）, Changqing Zhang* Lithium stimulates human bone marrow derived mesenchymal stem cell proliferation through GSK-3beta-dependent beta-catenin/Wnt pathway activation FEBS J 2014 281(23):5371-89
Bin Hu, Ye Guo, Chunyuan Chen, Qing Li, Xin Niu, Shangchun Guo, AijunZhang, Yang Wang* （通讯作者）, Zhifeng Deng* Repression of SIRT1 promotes the differentiation of mouse induced pluripotent stem cells into neural stem cells Cell Mol Neurobiol 2014 34(6): 905-912
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Guo F*, Guo X, Xie A, Lou YL, Wang Y# （通讯作者） The Suppressive Effects of Lanthanum on the Production of Inflammatory Mediators in Mice Challenged by LPS. Biol Trace Elem Res. 2011 142:693-703
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