导师姓名： 时海波 专业代码： 100213
性别： 男 专业名称： 耳鼻咽喉科学
培养单位： 附属第六人民医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师： 兼
联系方式：
邮编： 200233 邮箱地址： haibo99@hotmail.com

研究方向 (点击浏览详细信息)
耳-耳神经外科学，听觉医学，耳源性眩晕

社会任职
上海市政府采购评审专家
《听力学及言语疾病杂志》编委
《中华耳鼻咽喉-头颈外科杂志》编委
中华医学会耳鼻咽喉头颈外科学分会青年委员会 副主任委员
中国中西医结合耳鼻咽喉科专业委员会耳聋专家委员会 副主任委员
上海市医学会第四届医疗鉴定专家库 成员
上海市声学会常务理事兼生理学组主任委员
上海市医学会耳鼻咽喉头颈外科学分会委员、秘书、听力学组组长
《临床耳鼻咽喉头颈外科杂志》 编委
上海交通大学耳鼻咽喉科研究所 所长助理
上海市耳鼻咽喉科临床质量控制中心 委员
《中西医结合耳鼻咽喉头颈外科杂志》编委
《中华耳科学杂志》英文版 编委

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
MVN神经元兴奋性驱动神经发生调控前庭代偿 国家自然科学基金委 ?重点国际(地区)合作研究项目 2021-01~2025-12 247万元 课题负责人
2019YFC** 智能化良性阵发性位置性眩晕诊疗设备研发 科技部国家重点研发项目 2019-12~2021-12 571万元 课题负责人
00 联合听觉及前庭觉功能评估的梅尼埃病诊治新策略——随机、对照、多中心临床研究 上海交通大学医学院多中心临床研究项目 2019-01~2021-12 50万元 课题负责人
** 新生儿高胆红素血症合并酸中毒诱发严重前庭中枢神经毒性的作用机制 国家自然科学基金面上项目 2019-01~2022-12 53万元 课题负责人
00 Multifaceted Roles of Bilirubin in Promoting Neuronal Excitotoxicity via Membrane Ion Channels 上海交通大学医学院国际及港澳台地区科研合作项目 2018-10~2019-09 15万元 课题负责人
** 耳源性眩晕的临床特征及前庭功能代偿措施的优化 上海市人社局（上海市领军人才） 2017-06~2020-05 100万元 课题负责人
YG2016ZD02 多学科交叉项目培养（医工） 上海交通大学“科技创新专项资金” 2017-01~2019-12 75万元 课题负责人
16CR3041A 低频重复经颅磁刺激治疗慢性耳鸣 上海市申康医疗发展中心 2016-12~2019-06 50万元 课题负责人
** HCN通道对MVN神经元内在膜特性的调控是前庭发育及代偿的关键因素 国家自然科学基金委面上项目 2016-01~2019-12 57万元 课题负责人
** 耳源性眩晕诊治措施的优化 上海市教委“高峰高原学科建设计划” 2015-10~2021-09 200万元 课题负责人
** 未成熟期脑干听觉核团抑制性与兴奋性突触传递的协同作用决定其对胆红素神经毒性易感 国家自然科学基金委面上项目 2014-01~2017-12 100万元 课题负责人
XBR** 卫生系统优秀人才培养“新****” 上海市卫计委 2013-11~2016-10 90万元 课题负责人
11JC** 胆红素通过促进GABA/甘氨酸能突触传递诱发神经元兴奋毒性 上海市科委 2012-01~2014-12 30万元 课题负责人
2012CB961903 干细胞内耳植入及功能验证 973课题子项目 2012-01~2016-12 50万元 课题负责人
** 牛磺酸通过SGN 突触前体钙池的膜稳定作用拮抗胆红素耳毒性 国家自然科学基金委面上项目 2012-01~2015-12 60万元 课题负责人
** 局限性耳蜗损伤后的听觉中枢可塑性机制研究 国家自然科学基金委 2011-01~2013-12 25万元 主要责任人
00 上海市“白玉兰科技人才基金” 上海市科委 2009-01~2009-12 3万元 课题负责人
08JC** 上海市“创新行动计划”基础研究重点项目 上海市科委 2008-10~2010-09 25万元 课题负责人
00 教育部留学回国人员科研启动基金 教育部 2007-01~2009-12 3万元 课题负责人
08JC** 胆红素听觉神经毒性机制及干预的基础研究 上海市科委，基础重点项目 ~2010-09 25万元

学术论文 作者论文标题期刊名出版年卷期页码
Lai K, Song XL, Shi HS, Qi X, Li CY, Fang J, Wang F, Maximyuk O, Krishtal O, Xu TL, Li XY, Ni K, Li WP, Shi HB （通讯作者）, Wang LY, Yin SK Bilirubin enhances the activity of ASIC channels to exacerbate neurotoxicity in neonatal hyperbilirubinemia in mice Science Translation Medicine. 2020 2020 Feb 12;12(530). pii: eaax1337
Qiuwei Shi, Yazhi Xing, Lichao Wang, Gang Wang, Qinghong Zhang, Yaogang Li, Chengyi Hou*,Haibo Shi*, Hongzhi Wang （通讯作者） A self-healing, Na+ sensitive and neuron-compatible fiber Chemical Engineering Journal 2020 (2020)386:124018
Wang P, Yu D, Wang H, Ye H, Qiao R, Chen Z, Wu Y, Li Y, Shi H （通讯作者）, Zou J, Yin S. Contrast-Enhanced MRI Combined With the Glycerol Test Reveals the Heterogeneous Dynamics of Endolymphatic Hydrops in Patients With Menière's Disease .J Magn Reson Imaging 2020 2020 Mar 11. doi: 10.1002/jmri.27127
Li XY, Yu DZ, Jie H, Zhou H, Ye H, Ma G, Wan L, Li C,?Shi H （通讯作者）, Yin S Cytochrome P450 1A2 Is Incapable of Oxidizing?Bilirubin?Under Physiological Conditions. Front Pharmacol 2019 2019 Oct 18;10:1220
Qingxiu Yao, Hui Wang, Qiang Song, Haibo Shi （通讯作者）, Dongzhen Yu Use of the Barany Society criteria to diagnose benign paroxysmal positional vertigo Journal of Vestibular Research 2019 28(5-6):379-384
Wang P, Zhu H, Lu W, Song Q, Chen Z, Wu Y, Wang H, Yu D, Ye H, Shi H （通讯作者）, Yin S Subcellular Abnormalities of Vestibular Nerve Morphology in Patients With Intractable Meniere's Disease Front Neurol. 2019 2019 Sep 6;10:948. doi: 10.3389/fneur.2019.00948. eCollection 2019
Hao-Song Shi, Ke Lai, Xin-Lu Yin, Min Liang, Hai-Bo Ye, Hai-Bo Shi （通讯作者）, Lu-Yang Wang, Shan-Kai Yin. Ca 2+ -dependent recruitment of voltage-gated sodium channels underlies bilirubin-induced overexcitation and neurotoxicity. Cell Death and Disease 2019 2019;10(10):774.
Zhang J, Hong Y, Cao W, Yin S, Shi H （通讯作者）, Ying W SIRT2, ERK and Nrf2 Mediate NAD+ Treatment-Induced Increase in the Antioxidant Capacity of PC12 Cells Under Basal Conditions. Front Mol Neurosci 2019 12: 108
Wang H, Yao Q, Li Z, Yu D, Shi H （通讯作者） Characteristics of positional nystagmus in patients with horizontal canal canalolithiasis or cupulopathy J Neurology. 2019 2019 Oct;266(10):2475-2480
Liang Xia, Yangjia Cao, Yang Guo, Guangyi Ba, Qiong Luo, Haibo Shi （通讯作者）, Yanmei Feng, Shankai Yin A Novel Heterozygous Mutation of the COL4A3 Gene Causes a Peculiar Phenotype without Hematuria and Renal Function Impairment in a Chinese Family. Disease Markers 2019 2019: **
Liang Xia, Jingchun He, Yuanyuan Sun, Yi Chen, Qiong Luo, Haibo Shi （通讯作者）, Yanmei Feng, and Shankai Yin. Comparison of Acceptable Noise Level Generated Using Different Transducers and Response Modes. Neural Plast. 2018 2018:**
Yao Q, Xu C, Wang H, Shi H （通讯作者）, Yu D Video Head Impulse Test Results Suggest that Different Pathomechanisms Underlie Sudden Sensorineural Hearing Loss with Vertigo and Vestibular Neuritis:Our Experience in Fifty-Two Patients. Clin Otolaryngol 2018 43(6):1621-1624
HaiboYe, Yazhi Xing, Ling Zhang, Jianhui Zhang, Haiyan Jiang, DalianDing, Haibo Shi （通讯作者）, Shankai Yin Bilirubin-induced neurotoxic and ototoxic effects in rat cochlear and vestibular organotypic cultures. NeuroToxicology 2018 71:75-86
Yang SY, Zhu HM, Zhu BJ, Wang H, Shi HB （通讯作者）, Li YH, Zou J, Yin SK Correlations between the degree of endolymphatic hydrops and symptoms and audiological test results in patients with Meniere’s Disease : A reevaluation. Otol Neurotol 2018 39(3):351-356
Xin-Lu Yin, Hui-Qun Jie, Min Liang, Li-Na Gong, Han-Wei Liu, Hao-Lai Pan, Ya-Zhi Xing, Chun-Yan Li, Hai-Bo Shi* （通讯作者）, Lu-Yang WANG and Shan-Kai Yin Accelerated Development of the First-Order Central Auditory Neurons with Spontaneous Activity Frontiers in Molecular Neuroscience 2018 31;11:183
Min Liang, Xin-Lu Yin, Lu-Yang Wang, Wei-Hai Yin, Ning-Ying Song, Hai-Bo Shi （通讯作者）, Chun-Yan Li,Shan-Kai Yin NAD+ Attenuates Bilirubin-Induced Hyperexcitation in the Ventral Cochlear Nucleus by Inhibiting Excitatory Neurotransmission and Neuronal Excitability Front. Cell. Neurosci 2017 10.3389/fncel.2017.00021
Liang M, Yin XL, Shi HB （共同第一作者）, Li CY, Li XY, Song NY, Shi HS, Zhao Y, Wang LY, Yin SK. Bilirubin augments Ca2+ load of developing bushy neurons by targeting specific subtype of voltage-gated calcium channels. Sci Rep 2017 10.1038/s41598-017-00275-9
Cheng C, Guo L, Lu L, Xu X, Zhang S, Gao J, Waqas M, Zhu C, Chen Y, Zhang X, Xuan C, Gao X, Tang M, Chen F, Shi H （通讯作者）, Li H, Chai R Characterization of the Transcriptomes of Lgr5+ Hair Cell Progenitors and Lgr5- Supporting Cells in the Mouse Cochlea Front Mol Neurosci 2017 10.3389/fnmol.2017.00122
Waqas M, Sun S, Xuan C, Fang Q, Zhang X, Islam IU, Qi J, Zhang S, Gao X, Tang M, Shi H （通讯作者）, Li H, Chai R Bone morphogenetic protein 4 promotes the survival and preserves the structure of flow-sorted Bhlhb5+ cochlear spiral ganglion neurons in vitro Sci Rep. 2017 10.1038/s41598-017-03810-w
1.Shasha Zhang, Yuan Zhang, Pengfei Yu, Yao Hu, Han Zhou, Lingna Guo, Xiaochen Xu, Xiaocheng Zhu, Muhammad Waqas, Jieyu Qi, Xiaoli Zhang, Xiaoyun Qian, Fangyi Chen, Mingliang Tang, Yan Liu, Haibo Shi （通讯作者）, Xia Gao, Renjie Chai Characterization of Lgr5+ progenitor cell transcriptomes after neomycin injury in the neonatal mouse cochlea Front. Mol 2017 10.3389/fnmol.2017.00213
Hui Wang, Bei Li, Meiye Wang, Dongzhen Yu, Haibo Shi （通讯作者）, Shankai Yin Factor Analysis of Low-Frequency Repetitive Transcranial Magnetic Stimulation to the Temporoparietal Junction for Tinnitus Neural Plasticity 2016 Article ID **
Liu PP, Su KM, Zhu BJ, Wu YQ, Shi HB （通讯作者）, Yin SK Detection of eustachian tube openings by tubomanometry in adult otitis media with effusion Eur Arch Otorhinolaryngol. 2016 273(10):3109-15
Jiping Wang, Qiang Song, Dongzhen Yu, Guang Yang, Li Xia, Kaiming Su, Haibo Shi （通讯作者）, Jian Wang, Shankai Yin. Ontogenetic development of the auditory sensory organ in zebrafish (Danio rerio): changes in hearing sensitivity and related morphology. Sci Rep. 2015 10.1038/srep15943
Tan J, Yu D, Feng Y, Song Q, You J, Shi H （通讯作者）, Yin S First-referral presentations of patients with benign paroxysmal positional vertigo who were negative on positional testing and who lacked nystagmus Eur Arch Otorhinolaryngol 2015 272(11):3247-51
Wang H, Li B, Feng Y, Cui B, Wu H, Shi H （通讯作者）, Yin S. A Pilot Study of EEG Source Analysis Based Repetitive Transcranial Magnetic Stimulation for the Treatment of Tinnitus. PLoS One. 2015 10(10):e**
Wang H,Li B, Wu H, Shi H （通讯作者）, Yin S. Combination of gaps in noise detection and visual analog scale for measuring tinnitus components in patients treated with repetitive transcranial magnetic stimulation. Auris Nasus Larynx. 2015 S0385-8146(15)00209-6.
Su K, Zhang W, Shi H, Yin S Pedunculated cavernous hemangioma originating in the olfactory cleft Ear Nose Throat J 2014 93(9):E29-33
Song NY, Li CY, Yin XL, Liang M, Shi HB, Han GY, Yin SK Taurine protects against bilirubin-induced hyperexcitation in rat anteroventral cochlear nucleus neurons Exp Neurol 2014 254:216-23
Chen Z, Sun X, Zhou H, Shi H, Wu Y, Yin S Comparison of hearing results of malleovestibulopexy and total ossicular replacement prosthesis for chronic otitis media patients with a mobile stapes footplate Ann Otol Rhinol Laryngol 2014 123(5):343-6
Tan J, Yu D, Feng Y, Song Q, You J, Shi H （通讯作者）, Yin S. Comparative study of the efficacy of the canalith repositioning procedure versus the vertigo treatment and rehabilitation chair Acta Otolaryngol 2014 134(7):704-8
Shi H, Li Y, Yin S, Zou J The Predominant Vestibular Uptake of Gadolinium Through the Oval Window Pathway Is Compromised by Endolymphatic Hydrops in Ménière's Disease Otol Neurotol 2014 35(2):315-22
Ye HB, Wang J, Zhang WT, Shi HB （通讯作者）, Yin SK Taurine attenuates bilirubin-induced neurotoxicity in the auditory system in neonatal guinea pigs Int J Pediatr Otorhinolaryngol 2013 77(5):647-54
Ye HB, Shi HB （通讯作者）, Yin SK. Mechanisms underlying taurine protection against glutamate-induced neurotoxicity Can J Neurol Sci 2013 40(5):628-34
Zhou H, Chen Z, Shi H, Wu Y, Yin S Categories of auditory performance and speech intelligibility ratings of early-implanted children without speech training PLoS One 2013 8(1):e53852
Ye Haibo, Shi Haibo （通讯作者）, Wang Jian, et al Bilirubin Induces Auditory Neuropathy in Neonatal Guinea Pigs Via Auditory Nerve Fiber Damage Journal of Neuroscience Research 2012 90(11):2201-13
Li CY, Shi HB （通讯作者）, Ye HB, Song NY, Yin SK Minocycline cannot protect neurons against bilirubin-induced hyperexcitation in the ventral cochlear nucleus. Exp Neurol. 2012 237(1):96-102
Feng YM, Wu YQ, Shi HB （通讯作者） Cochlear implantation in long-term monaural deafness after acoustic Journal of laryngology and otology Journal of laryngology and otology 2011 125(7): 741-4
Li CY,Shi HB （通讯作者）,Yin SK Bilirubin enhances neuronal excitability by increasing glutamatergic transmission in the rat lateral superior olive Toxicology 2011 284(1-3):19-25
Li CY,Shi HB （通讯作者）,Yin SK Bilirubin facilitates depolarizing GABA/glycinergic synaptic transmission in the ventral cochlear nucleus of rats European Journal of Pharmacology 2011 660(2-3):310-7
Wang H, Shi HB （通讯作者）, SK Yin. Polyamidoamine dendrimers as gene delivery carriers in the inner ear: How to improve transfection efficiency. Experimental and therapeutic medicine 2011 2(5):777-781.
Li CY,Shi HB （通讯作者）,Chen ZN Protein kinase A and C signaling induces bilirubin potentiation of GABA/glycinergic synaptic transmission in rat ventral cochlear nucleus neurons Brain Research 2010 1348:30-41
Shi HB （通讯作者）,Kakazu Y,Shimada S Protein kinase A and C signaling induces bilirubin potentiation of Bilirubin potentiates inhibitory synaptic transmission in lateral superior olive neurons of the rat Neuroscience Research 2006 55(2):161-70
Shi HB （通讯作者）,Cheng L,Nakayama M Effective comparison of two auto-CPAP devices for treatment of obstructive sleep apnea based on polysomnlgraphic evaluation Auris Nasus Larynx 2005 32(3):237-41
Shi HB （通讯作者）, Masuda M, Umezaki T Irradiation impairment of umami taste in patients with head and neck cancer Auris Nasus Larynx 2004 31(4):401-6