导师姓名： 陈正侬 专业代码： 100213
性别： 男 专业名称： 耳鼻咽喉科学
培养单位： 附属第六人民医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师： 兼
联系方式：
邮编： 邮箱地址： jassey@126.com

研究方向 (点击浏览详细信息)
耳聋机制及防治

社会任职
中国医疗保健国际交流促进会耳鼻咽喉头颈外科分会青年委员会副主任委员
上海市医学会耳鼻咽喉头颈外科专科分会青年委员会副主任委员
中华耳科学杂志 编委
中国医师协会显微外科分会耳神经及侧颅底显微修复委员会主任委员
中华医学会耳鼻咽喉头颈外科分会青年委员会副主任委员
World Skull Base Group Faculty
国际耳内科协会委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** VGLUT3改善低强度噪声所致的听觉功能障碍 国家自然科学基金面上项目 2021-01~2024-12 56万元 课题负责人
** VGLUT3改善低强度噪声所致的听觉功能障碍 国家自然科学基金面上项目 2018-01~2021-12 70万元 课题负责人
15PJD030 FGF22防治噪声所致的Ribbon突触损伤 上海市科委 2015-08~2017-07 20万元 课题负责人
** Iduna通过拮抗Parthanatos防治噪声性聋 国家自然科学基金 2014-01~2017-12 70万元 课题负责人
** 改良AAV2载体提高目的基因耳蜗毛细胞转染效率的研究 国家自然科学基金 2010-01~2012-12 23万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Zheng Z, Shen Y, Xia L, Wu H, Zhou H, Tang X, Meng L, Wang H, Wu Y, Shi H, Yin S, Feng Y, Chen Z. （通讯作者） Glucocorticoid and Breviscapine Combination Therapy Versus Glucocorticoid Alone on Sudden Sensorineural Hearing Loss in Patients with Different Audiometric Curves Adv Ther 2020 37(12):4959-4968
Zhang Z, Fan L, Xing Y, Wang J, Aiken S, Chen Z* （通讯作者）, Wang J* Temporary Versus Permanent Synaptic Loss from Repeated Noise Exposure in Guinea Pigs and C57 Mice. Neuroscience 2020 28;432:94-103
He S, Hu J, Zheng Z, Wang J, Chen J, Zhang C, Li L, Wang J, Chen Z （通讯作者）, Shi H, Wang J Establishment of an induced pluripotent stem cell line from a patient with CHARGE syndrome carrying a CHD7 (p.L1151Gfs*17) mutation. Stem Cell Res 2020 May;45:101774
Zhuang Q, Wei N, Zhou Q, Wang H, Wu Y, Chen Z* （通讯作者）, Yu D, Wang P*, Shi H. Efficacy and Timing of Neonatal Ear Correction Molding. Aesthetic Plast Surg 2020 21
Fan L, Zhang Z, Wang H, Li C, Xing Y, Yin S, Chen Z （通讯作者）, Wang J. Pre-exposure to Lower-Level Noise Mitigates Cochlear Synaptic Loss Induced by High-Level Noise Front Syst Neurosci. 2020 12;14:25.
Li C, Zhou H, Feng Y, Zhao Y, Wang J, Chen Z （通讯作者）, Yin S. Coagulation States in Patients With Sudden Sensorineural Hearing Loss Evaluated by Thromboelastography Otolaryngol Head Neck Surg 2020 3:**5240
Wang J, Feng Y, Wang H, Li C, Wu Y, Shi H, Yin S （通讯作者）, Chen Z. Prevalence of High Jugular Bulb across Different Stages of Adulthood in A Chinese Population Aging Dis 2020 23;11(4):770-776
Huang S, Wang D, Zhou H, Chen Z* （通讯作者）, Wang H*, Li Y, Yin S* Neuroimaging consequences of cerebral small vessel disease in patients with obstructive sleep apnea-hypopnea syndrome. Brain Behav 2019 9(8):e01364
Wang JJ, Feng YM, Wang H, Wu YQ, Shi HB, Chen ZN* （通讯作者）, Yin SK* Changes in tinnitus after vestibular schwannoma surgery. Sci Rep 2019 11;9(1):1743
Wang JJ, Feng YM, Wang H, Wu YQ, Shi HB, Chen ZN* （通讯作者）, Yin SK Postoperative efficacy analysis of patients with facial nerve palsy associated with cholesteatoma otitis media: Our experience with 32 patients. Clin Otolaryngol. 2018 43(2):732-735
Sun Y, Guo Y, Wang H, Chen Z* （通讯作者）, Wu Y, Shi H, Feng Y*, Yin S Differences in platelet-related parameters among patients with audiographically distinct sudden sensorineural hearing loss: A retrospective study. Medicine (Baltimore) 2017 96(36):e7877
Zeng S, Sun X, Chen Z （通讯作者）, Yu D, Chen B, Yin S Low, but Not High, Doses of Cisplatin Damage Cochlear Hair Cells in C57 Mouse Organotypic Cultures. ORL J Otorhinolaryngol Relat Spec 2016 78(4):177-186.
王菁菁, 冯艳梅, 吴雅琴, 王慧, 时海波, 陈正侬 （通讯作者）, 殷善开 影响面神经减压术疗效的因素 上海交通大学学报（医学版） 2016 36(09): 1329-1331
Chen Z , Prasad SC, Di Lella F, Medina M, Piccirillo E, Taibah A, Russo A, Yin S, Sanna M The behavior of residual tumors and facial nerve outcomes after incomplete excision of vestibular schwannomas J Neurosurg 2014 120(6):1278-87
Ruan Q, Ao H, He J, Chen Z, Yu Z, Zhang R, Wang J, Yin S Topographic and quantitative evaluation of gentamicin-induced damage to peripheral innervation of mouse cochleae Neurotoxicology 2014 40:86-96
Ruan Q, Zeng S, Liu A, Chen Z, Yu Z, Zhang R, He J, Bance M, Robertson G, Yin S, Wang J Overexpression of X-Linked Inhibitor of Apoptotic Protein (XIAP) reduces age-related neuronal degeneration in the mouse cochlea Gene Ther 2014 21(11):967-74
Zhou H, Sun X, Chen Z （通讯作者）, Shi H, Zhang W, Yin S. Evaluation of cochlear implantation in children with inner ear malformation B-ENT 2014 10: 265-269
Chen Z, Zhou H, Shi H, Wu Y, Yin S Comparison of hearing results of MVP and TORP for chronic otitis media patients with a mobile stapes footplate Ann Otol Rhinol Laryngol 2014 123(5):343-6
Xia L, Chen Z, Su K, Yin S Comparison of cochlear cell death caused by cisplatin, alone and in combination with furosemide Toxicol Pathol 2014 42(2):376-85
Zhou H, Chen Z （通讯作者）, Shi H, Wu Y, Yin S Categories of Auditory Performance and Speech Intelligibility Ratings of Early-Implanted Children without Speech Training PLoS One 2013 8(1):e53852
Xia L, Chen Z （通讯作者）, Yin S Ototoxicity of cisplatin administered to guinea pigs via the round window membrane J Toxicol Sci 2012 37(4):823-30
Chen ZN, Yin SK. Cochlear implantation in a patient with bilateral temporal bone fractures resulting from temporomandibular joint surgery Chin Med J (Engl) 2012 125(22):4160
Ye HB, Shi HB, Wang J, Ding DL, Yu DZ, Chen ZN, Li CY, Zhang WT, Yin SK Bilirubin induces auditory neuropathy in neonatal guinea pigs via auditory nerve fiber damage J Neurosci Res 2012 90(11):2201-13
Zhou H, Chen Z （共同第一作者）, Shi H, Wu Y, Yin S Comparisons of auditory performance and speech intelligibility in children with cochlear implants placed using different approaches Otol Neurotol 2012 33(1):26-9
Li CY, Shi HB, Chen ZN, Ye HB, Song NY, Yin SK Protein kinase A and C signaling induces bilirubin potentiation of GABA/glycinergic synaptic transmission in rat ventral cochlear nucleus neurons Brain Res 2010 12:1348:30-41
Chen B, Yu D, Chen Z （共同第一作者）, Yin S. Fos expression in the rat vestibular nucleus complex after plugging the three semicircular canals Audiol Neurootol 2009 14(4):209-213
Chen Z, Jian Wang, Yin S. Off-channel effect of High Frequency Overstimulation on Duration Tuning of low-frequency Inferior Colliculus neurons of Guinea Pigs Acta Otolaryngol 2009 129(12):1451-5
Yu D, Chen Z, Yin S Effect of baclofen on neuronal activity in the medial vestibular nucleus after unilateral surgical labyrinthectomy in rats Acta Oto-Laryngologica 2009 129:735-740
Chen Z, Yu D, Wu Y, Shi H, Zhou H, Yin S The indications and common surgical approaches for cochlear implantation in China ORL J Otorhinolaryngol Relat Spec 2009 71(4):187-91
Chen Z, Yu D, Wu Y, Shi H, Zhou H, Wang J, Yin S Surgical treatment of labyrinthine fistula caused by cholesteatoma with semicircular canal occlusion Acta Otolaryngol 2009 1:1-4
Yin S, Chen Z, Wang L, Wu Y,. Suprameatal approach for cochlear implantation in 45 Chinese Children Int J Pediatr Otorhinolaryngol 2008 72(3):397-403
Chen Z, Yu D, Wu Y, Yin S, Wang J. Horizontal Semicircular Canal Occlusion in a Patient with Benign Paroxysmal Positional Vertigo J Otolaryngol Head Neck Surg 2008 37(3):E69-72
Yin S, Chen Z, Feng Y, Wang J Local Inhibition Shapes Duration Tuning in The Inferior Colliculus of Guinea Pigs Hear Res 2008 237(1-2):32-48
Yin S, Feng Y, Chen Z,Wang J The effect of noise-induced sloping high-frequency hearing loss on the gap response in the inferior colliculus and auditory cortex of guinea pigs Hear Res 2008 239(1-2):126-40
Yin S, Chen Z,Yu D, Wu Y, Shi H, Zhou H Triple Semicircular Canal Occlusion for the Treatment of Ménière’s Disease Acta Oto-Laryngologica 2008 128(7):739-43
Yin S, Chen Z, Feng Y, Wang J. The roles of local inhibition mediated by aminobutyric acid (GABA)-A receptor in duration tuning in the inferior colliculus of guinea pigs Acta Otolaryngol 2008 128(10):1101-9.
Yin S, Yu D, Chen Z, Cao Z, Wang J Important factors for the hearing loss caused by the triple semicircular canal occlusion in guinea pigs. Otol Neurotol. 2007 28(4):513-9.
Wang J, van Wijhe R, Chen Z （共同第一作者）, Yin S Is duration tuning a transient behavior in the inferior colliculus of guinea pigs? Brain Res 2006 1114(1):63-74
Wang LE, Cao KL, Yin SK, Wang Z, Chen ZN Cochlear function after selective spiral ganglion cells degeneration induced by ouabain. Chin Med J (Engl) 2006 119(12):974-9