导师姓名： 黄钢 专业代码： 100207
性别： 男 专业名称： 影像医学与核医学
培养单位： 附属胸科医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师： 兼
联系方式： huang2802@163.com
邮编： 邮箱地址： huang2802@163.com

研究方向 (点击浏览详细信息)
肿瘤核医学定量研究，肿瘤代谢机理及分子影像评价

社会任职
中华医学会核医学分会第九届主任委员
亚洲核医学学院院长
上海医学教育学会主任委员
中国医疗装备协会核医学装备与技术专业委员会副主任委员
高校医学教育副主编
高等医学教育杂志副主编
中国医师学会核医学专业委员会副会长
Clinical Medical education主编
中华生物医学工程杂志副主编
中华核医学与分子影像学杂志主编
Nucl. Sci.& Tech副主编
上海医学教育杂志副主编

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 代谢影像组学智能预测肺癌靶向耐药的关键技术与应用 国家自然科学基金重点项目 2019-01~2023-12 294万元 课题负责人
** 高分辨分子成像在肿瘤代谢重编程机制及精准靶点定位的 基础研究 国家自然科学基金重点项目 2016-01~2020-12 273万元 课题负责人
** 脂代谢显像与流量测定评价SREBP1对肺癌紫杉醇耐药的调节及其分子机制 国家自然基金 2015-01~2018-12 90万元 课题负责人
2012ZX09506-001-005 前列腺癌个体化诊疗关键生物标志物及其新型检测试剂盒研发关键技术 重大新药创制 2012-01~2015-12 321万元 课题负责人
2012CB932600 纳米界面生物分子作用机制的基础研究及其在前列腺癌早期检测中的应用 国家重大科学研究计划 2012-01~2015-12 348万元 子课题负责人
** 18F-FDG PET监测丙酮酸激酶M2调节靶向EGFR药物疗效的分子机制 国家自然基金委 2011-01~2013-12 33万元 课题负责人
10JC410000 18F-FDG PET监测丙酮酸激酶M2调节和靶向EGFR药物疗效的相关研究 上海市科学技术委员会 2010-10~2013-10 30万元 课题负责人
** 葡萄糖摄取速率定量监测相关基因与信号传导通路在糖酵解中的作用及肿瘤反应性的系统研究 国家自然基金委,重点项目 2009-01~2012-12 175万元 课题负责人
无创性PET定量参数动态评价肿瘤代谢特征 上海市科委，国际合作项目 2008-09~2010-09 25万元 课题负责人
07JC14039 生物影像动态监测新技术及相关标志物预测肿瘤化疗疗效的应用基础研究 上海市科委,重点基础研究 2007-12~2009-11 50万元 课题负责人
07ZZ34 分子生物影像检测化疗药物早期疗效的方法学及机制研究 上海市教委,发展基金 2007-01~2009-12 10万元 课题负责人
LJ06002 32P纳米核素诊断与清除肿瘤淋巴结转移的机理研究 上海市卫生局,医学领军人才 2006-01~2008-12 50万元 课题负责人
08JC** 18F-FDG PET/CT监测P53调节肿瘤细胞活性与凋亡的机理研究 上海市科委，基础重点项目 ~2010-09 30万元
08JC** 18F-FDG PET/CT监测P53调节肿瘤细胞活性与凋亡的机理研究 上海市科委，基础重点项目 ~2010-09 30万元

学术论文 作者论文标题期刊名出版年卷期页码
Zhang A, Wu T, Bian L, Li P, Liu Q, Zhang D, Jin Q, Zhang J, Huang G （通讯作者）, Song S, Synthesis and Evaluation of Ga-68-Labeled Rhein for Early Assessment of Treatment-Induced Tumor Necrosis. Mol Imaging Biol 2020 2020 Jun;22(3)
Li P, Wang X, Xu C, Liu C, Zheng C, Fulham MJ, Feng D, Wang L, Song S, Huang G （通讯作者）, F-FDG PET/CT radiomic predictors of pathologic complete response (pCR) to neoadjuvant chemotherapy in breast cancer patients. Eur. J. Nucl. Med. Mol. Imaging 2020 2020 May;47(5)
Zhao H, Meng H, Wen J, Wang C, Liu J, Huang G （通讯作者）, Noninvasive Classification of Human Triple Negative Breast Cancer by PET Imaging with GRP78-Targeted Molecular Probe [Ga]DOTA-VAP. Mol Imaging Biol 2020 2020 Jun;22(3)
Hua Q, Mi B, Xu F, Wen J, Zhao L, Liu J, Huang G （通讯作者）, Hypoxia-induced lncRNA-AC020978 promotes proliferation and glycolytic metabolism of non-small cell lung cancer by regulating PKM2/HIF-1α axis. Theranostics 2020 2020;10(11)
Wei W, Rosenkrans ZT, Liu J, Huang G （通讯作者）, Luo QY, Cai W, ImmunoPET: Concept, Design, and Applications. Chem. Rev. 2020 2020 Apr 22;120(8)
Zhang A, Li P, Liu Q, Peng S, Huang G （通讯作者）, Song S, EFFECT OF POST-SURGICAL RAI THERAPY ON PARATHYROID FUNCTION IN PATIENTS WITH DIFFERENTIATED THYROID CANCER. Endocr Pract 2020 2020 Apr;26(4)
Li P, Zhang A, Liu Y, Xu C, Tang L, Yuan H, Liu Q, Wang X, Feng D, Wang L, Huang G （通讯作者）, Song S, Radioactive Iodine Therapy in Patients with Differentiated Thyroid Cancer: Study of External Dose Rate Attenuation Law and Individualized Patient Management. Thyroid 2019 2019 01;29(1)
Shi L, Yan H, An S, Shen M, Jia W, Zhang R, Zhao L, Huang G （通讯作者）, Liu J, SIRT5-mediated deacetylation of LDHB promotes autophagy and tumorigenesis in colorectal cancer. Mol Oncol 2019 2019 02;13(2)
Yang H, Zhu R, Zhao X, Liu L, Zhou Z, Zhao L, Liang B, Ma W, Zhao J, Liu J, Huang G （通讯作者）, Sirtuin-mediated deacetylation of hnRNP A1 suppresses glycolysis and growth in hepatocellular carcinoma. Oncogene 2019 2019 06;38(25)
Chen R, Zhou X, Liu J, Huang G （通讯作者）, Relationship between the expression of PD-1/PD-L1 and F-FDG uptake in bladder cancer. Eur. J. Nucl. Med. Mol. Imaging 2019 2019 06;46(6)
Yan H, Zhou X, Wang X, Li R, Shi Y, Xia Q, Wan L, Huang G （通讯作者）, Liu J, Delayed F FDG PET/CT Imaging in the Assessment of Residual Tumors after Transurethral Resection of Bladder Cancer. Radiology 2019 2019 10;293(1)
Wen J, Min X, Shen M, Hua Q, Han Y, Zhao L, Liu L, Huang G （通讯作者）, Liu J, Zhao X, ACLY facilitates colon cancer cell metastasis by CTNNB1. J. Exp. Clin. Cancer Res. 2019 2019 Sep 12;38(1)
Hua Q, Jin M, Mi B, Xu F, Li T, Zhao L, Liu J, Huang G （通讯作者）, LINC01123, a c-Myc-activated long non-coding RNA, promotes proliferation and aerobic glycolysis of non-small cell lung cancer through miR-199a-5p/c-Myc axis. J Hematol Oncol 2019 2019 09 05;12(1)
Chen Y, Zhou M, Liu J, Huang G （通讯作者）, Prognostic Value of Bone Marrow FDG Uptake Pattern of PET/CT in Newly Diagnosed Diffuse Large B-cell Lymphoma. Journal of Cancer 2018 2018;9(7)
Zhao X, Zhao L, Yang H, Li J, Min X, Yang F, Liu J, Huang G （通讯作者）, Pyruvate kinase M2 interacts with nuclear sterol regulatory element-binding protein 1a and thereby activates lipogenesis and cell proliferation in hepatocellular carcinoma. J. Biol. Chem. 2018 2018 04 27;293(17)
Liu Q, Qian Y, Li P, Zhang S, Liu J, Sun X, Fulham M, Feng D, Huang G （通讯作者）, Lu W, Song S, I-Labeled Copper Sulfide-Loaded Microspheres to Treat Hepatic Tumors via Hepatic Artery Embolization. Theranostics 2018 2018;8(3)
Liu Q, Qian Y, Li P, Zhang S, Wang Z, Liu J, Sun X, Fulham M, Feng D, Chen Z, Song S, Lu W, Huang G （通讯作者）, The combined therapeutic effects of iodine-labeled multifunctional copper sulfide-loaded microspheres in treating breast cancer. Acta Pharm Sin B 2018 2018 May;8(3)
Shen M, Zhao X, Zhao L, Shi L, An S, Huang G （通讯作者）, Liu J, Met is involved in TIGAR-regulated metastasis of non-small-cell lung cancer. Mol. Cancer 2018 2018 05 12;17(1)
Min X, Wen J, Zhao L, Wang K, Li Q, Huang G （通讯作者）, Liu J, Zhao X, Role of hepatoma-derived growth factor in promoting de?novo lipogenesis and tumorigenesis in hepatocellular carcinoma. Mol Oncol 2018 2018 09;12(9)
Jia W, Zhao X, Zhao L, Yan H, Li J, Yang H, Huang G （通讯作者）, Liu J, Non-canonical roles of PFKFB3 in regulation of cell cycle through binding to CDK4. Oncogene 2018 2018 03;37(13)
Zhou M, Chen Y, Liu J, Huang G （通讯作者）, A predicting model of bone marrow malignant infiltration in F-FDG PET/CT images with increased diffuse bone marrow FDG uptake. Journal of Cancer 2018 2018;9(10)
Hua Q, Mi B, Huang G （通讯作者）, The emerging co-regulatory role of long noncoding RNAs in epithelial-mesenchymal transition and the Warburg effect in aggressive tumors. Crit. Rev. Oncol. Hematol. 2018 2018 Jun;126
An Shuxian, Zhou Xiang, Liu Jianjun, Huang Gang （通讯作者）, F-fluorodeoxyglucose uptake predicts MET expression in lung adenocarcinoma. Onco Targets Ther 2017;10 2017 2017;10
Chen Ruohua, Li Jiajin, Zhou Xiang, Liu Jianjun, Huang Gang （通讯作者）, Fructose-1,6-Bisphosphatase 1 Reduces F FDG Uptake in Hepatocellular Carcinoma. Radiology 2017 2017 09;284(3)
Liu Liu, Xiaoping Zhao, Li Zhao, Jiajin Li, Hao Yang, Zongping Zhu, Jianjun Liu, andGang Huang （通讯作者） Arginine Methylation of SREBP1a via PRMT5 Promotes De Novo Lipogenesisand Tumor Growth CANCER RESEARCH 2016 76(5) March 1,
Liangqian Huang, Zhenhai Yu, Zhenchao Zhang, Wenjing Ma, Shaoli Song,Gang Huang （通讯作者） Interaction with Pyruvate Kinase M2 Destabilizes Tristetraprolin Scientific Reports 2016 6:22449
Chen Ruohua, Chen Yumei, Liu Liu, Zhou Xiang, Liu Jianjun, Huang Gang （通讯作者）, The Role of 1?F-FDG PET/CT in the Evaluation of Peritoneal Thickening of Undetermined Origin. Medicine (Baltimore) 2016 2016 Apr;95(15)
Z Zhu, X Zhao, L Zhao, H Yang, L Liu, J Li, J Wu, F Yang, G Huang and J Liu （通讯作者） p54nrb/NONO regulates lipid metabolism and breast cancer growth through SREBP-1A ONCOGENE 2016 2016 Mar 17;35(11):1399-410.
Chen Ruohua, Zhou Xiang, Liu Jianjun, Huang Gang （通讯作者）, Relationship Between 18F-FDG PET/CT Findings and HER2 Expression in Gastric Cancer Journal of Nuclear Medicine 2016 2016 07;57(7)
Xiang Zhou, Ruohua Chen, Wenhui Xie, Yicheng Ni, Jianjun Liu, Gang Huang （通讯作者） Relationship Between 18F-FDG Accumulation and Lactate Dehydrogenase A Expression in Lung Adenocarcinomas THE JOURNAL OF NUCLEAR MEDICINE 2015 Vol. 55 ? No. 11
Zhou X., R. Chen, Z. Yu, R. Li, J. Li, X. Zhao, S. Song, J. Liu （通讯作者）, G. Huang, Dichloroacetate restores drug sensitivity in paclitaxel-resistant cells by inducing citric acid accumulation. Mol Cancer, 2015 14: p. 63
Chen, R., X. Zhou, Z. Yu, J. Liu （通讯作者）, G. Huang Low Expression of LDHB Correlates With Unfavorable Survival in Hepatocellular Carcinoma: Strobe-Compliant Article. Medicine (Baltimore) 2015 94(39): p. e1583
Huang C., S. Sheng, R. Li, X. Sun, J. Liu, G. Huang （通讯作者） Lactate promotes resistance to glucose starvation via upregulation of Bcl-2 mediated by mTOR activation. Oncol Rep 2015 33(2): p. 875-84
Xue H., Y. Lu, Z. Xue, B. Lin, J. Chen, F. Tang, G. Huang （通讯作者） he effect of CYP1A1 and CYP1A2 polymorphisms on gastric cancer risk among different ethnicities: a systematic review and meta-analysis Tumour Biol 2014 35(5): p. 4741-56
Yu, Z., Y. Ge, L. Xie, T. Zhang, L. Huang, X. Zhao, J. Liu （通讯作者）, G. Huang Using a yeast two-hybrid system to identify FTCD as a new regulator for HIF-1alpha in HepG2 cells Cell Signal 2014 26(7): p. 1560-6
Yu, Z., X. Zhao, Y. Ge, T. Zhang, L. Huang, X. Zhou, L. Xie, J. Liu （通讯作者）, G. Huang A Regulatory Feedback Loop between HIF-1alpha and PIM2 in HepG2 Cells. PLoS One 2014 9(2): p. e88301
Huang L., Z. Yu, T. Zhang, X. Zhao, G. Huang （通讯作者） HSP40 interacts with pyruvate kinase M2 and regulates glycolysis and cell proliferation in tumor cells PLoS One 2014 9(3): p. e92949
Tang S, Huang G （通讯作者）, Fan W, Chen Y, Ward JM, Xu X, Xu Q, Kang A, McBurney MW, Fargo DC, Hu G, Baumgart-Vogt E, Zhao Y, Li X, SIRT1-mediated deacetylation of CRABPII regulates cellular retinoic acid signaling and modulates embryonic stem cell differentiation Mol Cell 2014 55(6): p. 843-55
Tang S., G. Huang （通讯作者）, X. Tong, L. Xu, R. Cai, J. Li, X. Zhou, S. Song, C. Huang, and J. Cheng Role of SUMO-Specific Protease 2 in Reprogramming Cellular Glucose Metabolism PLoS One 2013 8(5): p. e63965
Li J., S. Zhao, X. Zhou, T. Zhang, L. Zhao, P. Miao, S. Song, X. Sun, J. Liu, X. Zhao, G. Huang （通讯作者） Inhibition of lipolysis by mercaptoacetate and etomoxir specifically sensitize drug-resistant lung adenocarcinoma cell to Paclitaxel. PLoS One 2013 8(9): p. e74623.
Ding G., H.D. Liu, Q. Huang, H.X. Liang, Z.H. Ding, Z.J. Liao,G. Huang （通讯作者） HDAC6 promotes hepatocellular carcinoma progression by inhibiting P53 transcriptional activity. FEBS Lett 2013 587(7): p. 880-6.
Zhou X., R. Chen, W. Xie, Y. Ni, J. Liu, G. Huang （通讯作者） Relationship Between 18F-FDG Accumulation and Lactate Dehydrogenase A Expression in Lung Adenocarcinomas. J Nucl Med 2013 55(11): p. 1766-7
Miao P., S. Sheng, X. Sun, J. Liu, G. Huang （通讯作者） Lactate dehydrogenase a in cancer: A promising target for diagnosis and therapy. IUBMB Life 2013 65(11): p. 904-10
Wang Z., J. Lu, J. Gong, L. Zhang, Y. Xu, S. Song, K. Chen, F. Liu, H. Gang （通讯作者） CT-Guided Radioactive I Seed Implantation Therapy of Symptomatic Retroperitoneal Lymph Node Metastases Cardiovasc Intervent Radiol 2013 Feb;37(1):125-31.
Zhou X., W. Xie, Q. Li, Y. Zhang, J. Zhang, X. Zhao, J. Liu, G. Huang （通讯作者） TIGAR Is Correlated with Maximal Standardized Uptake Value on FDG-PET and Survival in Non-Small Cell Lung Cancer PLoS One 2013 8(7): p. e69963
Yu Z., X. Zhao, L. Huang, T. Zhang, F. Yang, L. Xie, S. Song, P. Miao, L. Zhao, X. Sun, J. Liu, G. Huang （通讯作者） roviral Insertion in Murine Lymphomas 2 (PIM2) Oncogene Phosphorylates Pyruvate Kinase M2 (PKM2) and Promotes Glycolysis in Cancer Cells. J Biol Chem 2013 288(49): p. 35406-16
Wang YT, Huang G （通讯作者）, Is FDG PET/CT cost-effective for pre-operation staging of potentially operative non-small cell lung cancer? - From Chinese healthcare system perspective Eur J Radiol 2012 81(8):e903-e909
Li R, Liu J, Xue H, Huang G （通讯作者）, Diagnostic value of fecal tumor M2-pyruvate kinase for CRC screening: a systematic review and meta-analysis Int J Cancer 2012 131(8):1837-1845.
Zhang C, Tong J, Sun X, Liu J, Wang Y, Huang G （通讯作者）, (18) F-FDG-PET evaluation of treatment response to neo-adjuvant therapy in patients with locally advanced rectal cancer: A meta-analysis Int J Cancer, 2012 131(11):2604-2611
Xue H, Lin B, An J, Zhu Y, Huang G （通讯作者）, Interleukin-10-819 promoter polymorphism in association with gastric cancer risk. BMC Cancer 2012 2012 Mar 21;12
Yuting Wang, Chengpeng Zhang, Jianjun Liu , Gang Huang （通讯作者） Is 18F-FDG PET accurate to predict neoadjuvant therapy response in breast cancer? Breast Cancer Res Treat, 2012 131(2):357-369
Xue H, Lu Y, Lin B, Chen J, Tang F, Huang G （通讯作者）, The Effect of XPD/ERCC2 Polymorphisms on Gastric Cancer Risk among Different Ethnicities: A Systematic Review and Meta-Analysis PLoS One, 2012 2012;7(9)
Sheng SL, Liu JJ, Dai YH, Sun XG, Xiong XP, Huang G （通讯作者）, Knockdown of lactate dehydrogenase A suppresses tumor growth and metastasis of human hepatocellular carcinoma FEBS 2012 2012 Oct;279(20)
Xue H, Qiao Y, Ni P, Wang J, Chen C, Huang G （通讯作者）, A CRE that binds CREB and contributes to PKA-dependent regulation of the proximal promoter of human RAB25 gene Int J Biochem Cell Biol 2011 2011 Mar;43(3)
Xue H, Ni P, Lin B, Xu H, Huang G （通讯作者）, X-ray repair cross-complementing group 1 (XRCC1) genetic polymorphisms and gastric cancer risk: A HuGE review and meta-analysis Am J Epidemiol 2011 2011 Feb 15;173(4)
Song SL, Deng C, Wen LF, Liu JJ, Wang H, Feng D, Wong CY, Huang G （通讯作者）, 18F-FDG PET/CT-related metabolic parameters and their value in early prediction of chemotherapy response in a VX2 tumor model. NUCLEAR MEDICINE AND BIOLOGY 2010 2010 Apr;37(3)
Gu P, Pan LL, Wu SQ, Sun L, Huang G （通讯作者）, CA 125, PET alone, PET-CT, CT and MRI in diagnosing recurrent ovarian carcinoma: a systematic review and meta-analysis. Eur J Radiol 2009 2009 Jul;71(1)
Pan L, Gu P, Huang G （通讯作者）, Xue H, Wu S, Prognostic significance of SUV on PET/CT in patients with esophageal cancer: a systematic review and meta-analysis. Eur J Gastroenterol Hepatol 2009 2009 Sep;21(9)
Sheng SL, Huang G （通讯作者）, Yu B, Qin WX, Clinical significance and prognostic value of serum Dickkopf-1 concentrations in patients with lung cancer. Clinical Chemistry 2009 2009 Sep;55(9)
LingLing Pan, Ping Gu, ShuQi Wu ,Gang Huang （通讯作者） Fluorine-18-fluorodeoxyglucose-PET/computed tomography has a role in predicting the outcome of hepatocellular carcinoma EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY 2009 21(7): 771-775
Zhang C, Chen Y, Xue H, Zheng P, Tong J, Liu J, Sun X, Huang G （通讯作者）, Diagnostic value of FDG-PET in recurrent colorectal carcinoma: a meta-analysis. Int J Cancer 2009 124(1):167-73
Chen YM, Huang G （通讯作者）, Sun XG, Liu JJ, Chen T, Shi YP, Wan LR, Optimizing delayed scan time for FDG PET: Comparison of the early and late delayed scan. Nucl Med Commun 2008 29(5):425-30
Sheng SL, Bao SH, Huang G （通讯作者）, Wang LM, Development of time-resolved immunofluorometric assays for vascular endothelial growth factor and application on plasma of patients with gastric tumours. Clin Exp Immunol 2008 151(3):459-66
Song SL, Liu JJ, Huang G （通讯作者）, Wang ZH, Song YY, Sun XG, Chen T, Changes in 18F-FDG Uptake Within Minutes After Chemotherapy in a Rabbit VX2 Tumor Model. J Nucl Med 2008 49(2):303-309.
Wang H, Fu HL, Li JN, Zhou RJ, Hui Gu Z, Wu JC, Huang G （通讯作者）, Comparison of whole-body (18)F-FDG SPECT and posttherapeutic (131)I scintigraphy in the detection of metastatic thyroid cancer Clin Imaging 2008 32(1):32-7
Wang H, Fu HL, Li JN, Zhou RJ, Hui Gu Z, Wu JC, Huang G （通讯作者）, Comparison of whole-body (18)F-FDG SPECT and posttherapeutic (131)I scintigraphy in the detection of metastatic thyroid cancer. Clin Imaging 2008 32(1):32-7
Han Y, Qin W, Huang G （通讯作者）, Knockdown of RCAS1 expression by RNA interference recovers T cell growth and proliferation. Cancer Lett 2007 257(2):182-190
Liu T, Xu W, Yan WL, Ye M, Bai YR, Huang G （通讯作者）, FDG-PET, CT, MRI for diagnosis of local residual or recurrent nasopharyngeal carcinoma, which one is the best? A systematic review. Radiotherapy and Oncology 2007 85:327-335
Sheng SL, Wang Q, Huang G （通讯作者）, Development of time-resolved immunofluorometric assays for CA 72-4 and application in sera of patients with gastric tumors. Clin Chim Acta 2007 380(1-2):106-11
Gu P, Huang G （通讯作者）, Chen Y, Zhu C, Yuan J, Sheng S, Diagnostic utility of pleural fluid carcinoembryonic antigen and CYFRA 21-1 in patients with pleural effusion: a systematic review and meta-analysis. J Clin Lab Anal 2007 21(6):398-405