导师姓名： 王瑞 专业代码： 100210
性别： 男 专业名称： 外科学
培养单位： 附属胸科医院 三级学科/
专业领域： 胸心外
导师类型： 硕士生导师 专业学位导师：
联系方式： 手机号码 **
邮编： rui_wang788@163.com 邮箱地址： rui_wang788@163.com

研究方向 (点击浏览详细信息)
肺癌微创手术治疗及个体化综合治疗

社会任职
上海医药卫生青年联合会委员
中国医药教育协会肺部肿瘤专委会委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 驱动实体亚型肺腺癌基因异常筛选和鉴定研究 国家自然基金面上项目 2018-01~2021-12 50万元 课题负责人
2017YQ018 通过影像和分子特征建立预测肺实性结节性质模型研究 上海市卫计委优秀青年项目 2017-09~2020-09 30万元 课题负责人
201706 早期肺腺癌复发转移高危分子标志物鉴定研究 上海人才发展资金 2016-09~2019-09 12万元 课题负责人
16QA** 非小细胞肺癌中MET驱动突变鉴定及功能机制研究 上海市科委青年科技青明星项目 2016-01~2018-12 40万元 课题负责人
320.6750.14317 非小细胞肺癌新型致癌基因突变鉴定及致癌机制研究 吴阶平基金项目 2015-01~2017-12 5万元 课题负责人
** 肿瘤相关成纤维细胞在非小细胞肺癌 EGFR-TKI 耐药中作用与机制研究 国家自然科学基金青年项目 2015-01~2017-12 24万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Chunji Chen#, Yiyang Wang#, Shijie Fu#, Xufeng Pan, Jun Yang, Rui Wang （通讯作者） The impact on mediastinal recurrence based on the number of harvested mediastinal lymph nodes and assessed N2 Stations in patients with stage I invasive lung adenocarcinoma J Thorac Dis 2018 10.21037/jtd.2018.11.31
Chunji Chen1#, Yiyang Wang1#, Xufeng Pan1#, Shijie Fu1, Yubo Shi2, Jun Yang1, Rui Wang （通讯作者） Choice of the surgical approach for patients with stage I lung squamous cell carcinoma ≤3 cm J Thorac Dis 2018 10.21037/jtd.2018.11.51
Bu S, Wang R （共同第一作者）, Pan Y, Yu S, Shen X, Li Y, Sun Y, Chen H. Clinicopathologic Characteristics of Patients with HER2 Insertions in Non-small Cell Lung Cancer. Ann Surg Oncol. 2017 24(1):291-297.
Wang Y, Wang R （共同第一作者）, Zheng D, Han B, Zhang J, Zhao H, Luo J, Zheng J, Chen T, Huang Q, Sun Y, Chen H The indication of completion lobectomy for lung adenocarcinoma ≤3 cm after wedge resection during surgical operation. J Cancer Res Clin Oncol. 2017 143(10):2095-2104.
Luo J, Wang R （共同第一作者）, Han B, Zhang J, Zhao H, Fang W, Luo Q, Yang J, Yang Y, Zhu L, Chen T, Cheng X, Huang Q, Wang Y, Zheng J, Chen H. Solid predominant histologic subtype and early recurrence predict poor postrecurrence survival in patients with stage I lung adenocarcinoma. Oncotarget. 2017 8(4):7050-7058.
Gu C, Wang R （共同第一作者）, Pan X, Huang Q, Luo J, Zheng J, Wang Y, Shi J, Chen H Comprehensive study of prognostic risk factors of patients underwent pneumonectomy J Cancer. 2017 8(11):2097-2103
Zheng D, Wang R （共同第一作者）, Ye T, Yu S, Hu H, Shen X, Li Y, Ji H, Sun Y, Chen H. MET exon 14 skipping defines a unique molecular class of non-small cell lung cancer. Oncotarget. 2016 7(27):41691-41702.
Zheng D, Wang R （共同第一作者）, Zhang Y, Pan Y, Cheng X, Cheng C, Zheng S, Li H, Gong R, Li Y, Shen X, Sun Y, Chen H. The prevalence and prognostic significance of KRAS mutation subtypes in lung adenocarcinomas from Chinese populations. Onco Targets Ther. 2016 9:833-43.
Luo J, Wang R （共同第一作者）, Han B, Zhang J, Zhao H, Fang W, Luo Q, Yang J, Yang Y, Zhu L, Chen T, Cheng X, Huang Q, Wang Y, Zheng J, Chen H. Analysis of the clinicopathologic characteristics and prognostic of stage I invasive mucinous adenocarcinoma. J Cancer Res Clin Oncol. 2016 142(8):1837-45.
Luo J, Huang Q, Wang R （共同第一作者）, Han B, Zhang J, Zhao H, Fang W, Luo Q, Yang J, Yang Y, Zhu L, Chen T, Cheng X, Wang Y, Zheng J, Wu H, Xia W, Chen H. Prognostic and predictive value of the novel classification of lung adenocarcinoma in patients with stage IB. J Cancer Res Clin Oncol. 2016 142(9):2031-40.
Zheng D, Wang R （共同第一作者）, Zhang Y, Pan Y, Cheng X, Cheng C, Zheng S, Li H, Gong R, Li Y, Shen X, Sun Y, Chen H Prevalence and clinicopathological characteristics of ALK fusion subtypes in lung adenocarcinomas from Chinese populations. J Cancer Res Clin Oncol. 2016 142(4):833-43.
Zheng S, Wang R （共同第一作者）, Zhang Y, Pan Y, Cheng C, Zheng D, Sun Y, Chen H. Former smokers with non-small-cell lung cancers: a comprehensive investigation of clinicopathologic characteristics, oncogenic drivers, and prognosis. Cancer Med. 2016 5(8):2117-25.
Jiang WY, Wang R （共同第一作者）, Pan XF, Shen YZ, Chen TX, Yang YH, Clinicopathological features and prognosis of primary pulmonary lymphoepithelioma-like carcinoma. J Thorac Dis. 2016 8(9):2610-2616.
Gu C, Pan X, Wang R （共同第一作者）, Li Y, Shen X, Shi J, Chen H. Analysis of mutational and clinicopathologic characteristics of lung adenocarcinoma with clear cell component. Oncotarget. 2016 7(17):24596-603.
Zhao Y, Wang R, Shen X, Pan Y, Cheng C, Li Y, Shen L, Zhang Y, Li H, Zheng D, Ye T, Zheng S, Sun Y, Chen H. Minor Components of Micropapillary and Solid Subtypes in Lung Adenocarcinoma are Predictors of Lymph Node Metastasis and Poor Prognosis. Ann Surg Oncol. 2016 23(6):2099-105
Shilei Liu, Rui Wang （共同第一作者）, Yang Zhang, Yuan Li, Chao Cheng, Yunjian Pan, Jiaqing Xiang, Yawei Zhang, Haiquan Chen, and Yihua Sun Precise diagnosis of intraoperative frozen section is an effective method to guide resection strategy for peripheral small-sized lung adenocarcinoma. J Clin Oncol 2016 34:307-313.
Zheng D, Wang R （共同第一作者）, Pan Y, Sun Y Prevalence and Clinicopathological Characteristics of BRAF Mutations in Chinese Patients with Lung Adenocarcinoma. Ann Surg Oncol. 2015 Suppl 3:1284-91.
Zhang J, Wang S, Wang L, Wang R （共同第一作者）, Chen S, Pan B, Sun Y, Chen H Prognostic value of Bcl-2 expression in patients with non-small-cell lung cancer: a meta-analysis and systemic review. Onco Targets Ther. 2015 18;8:3361-9
Cheng C, Wang R （共同第一作者）, Li Y, Pan Y, Zhang Y, Li H, Zheng D, Zheng S, Shen X, Sun Y, Chen H. EGFR Exon 18 Mutations in East Asian Patients with Lung Adenocarcinomas: A Comprehensive Investigation of Prevalence, Clinicopathologic Characteristics and Prognosis. Sci Rep. 2015 5:13959
Wang R, Zhang Y, Pan Y, Li Y, Hu H, Cai D, Li H, Ye T, Luo X, Zhang Y, Li B, Shen L, Sun Y, Chen H Comprehensive investigation of oncogenic driver mutations in Chinese non-small cell lung cancer patients. Oncotarget. 2015 6(33):34300-8
Zhang Y, Wang R （共同第一作者）, Li Y, Pan Y, Sun Y, Chen H Negative Thyroid Transcription Factor 1 (TTF1) Expression Defines an Unfavorable Subgroup of Lung Adenocarcinomas. J Thorac Oncol. 2015 10(10):1444-50.
Wang R,Wang L,Li Y,Hu H,Shen L, Sun Y, Chen H. FGFR1/3 tyrosine kinase fusions define a unique molecular subtype of non-small cell lung cancer. Clin Cancer Res 2014 20(15):4107-14
Wang L, Wang R （共同第一作者）, Pan Y, Sun Y, Zhang J, Chen H. The Pemetrexed-containing Treatments in the Non-small Cell Lung Cancer, is -/low Thymidylate Synthase Expression Better than +/high Thymidylate Synthase Expression? A Meta-analysis. BMC Cancer 2014 14:205
Wang R, Pan Y, Li C, Zhang H, Sun Y, Chen H Analysis of major known driver mutations and prognosis in resected adenosquamous lung carcinomas J Thorac Oncol. 2014 9(6):760-8.
Zhang Y, Wang R （共同第一作者）, Cai D, Li Y, Pan Y, Chen h A comprehensive investigation of molecular features and prognosis of lung adenocarcinoma with micropapillary component. J Thorac Oncol. 2014 9(12):1772-8
Zhang Y, Li J, Wang R （共同第一作者）, Sun Y, Chen H. The prognostic and predictive value of solid subtype in invasive lung adenocarcinoma. Sci Rep. 2014 4:7163
Pan Y, Wang R （共同第一作者）, Ye T, Li C, Hu H, Yu Y, Zhang Y, Wang L, Luo X, Li H, Li Y, Shen L, Sun Y, Chen H. Comprehensive Analysis of Oncogenic Mutations in Lung Squamous Cell Carcinoma with Minor Glandulra Component. Chest. 2014 145(3):473-9
Zhang J, Wang R （共同第一作者）, Liu S, Luketich JD, Chen S, Chen H, Schuchert MJ. Refinement of minimally invasive esophagectomy techniques after 15 years of experience. J Gastrointest Surg. 2012 16(9):1768-74.
Wang R, Pan Y, Li C, Zhang Y, Li H, Sun Y, Chen H The Use of Quantitative Real-Time Reverse Transcriptase PCR for 5' and 3' Portions of ALK Transcripts to Detect ALK Rearrangements in Lung Cancers. Clin Cancer Res 2012 18(17):4725-32
Wang R, Hu H, Pan Y, Y Li, T Ye, Sun Y, Chen H RET fusions define a unique molecular and clinicopathologic subtype of non-small-cell lung cancer J Clin Oncol 2012 30:4352-4359
Wang R （共同第一作者）, Zhang J, Chen S, Lu M, Luo X, Yao S, Liu S, Qin Y, Chen H. Tumor-associated macrophages provide a suitable microenvironment for non-small lung cancer invasion and progression. Lung Cancer 2011 74(2):188-96.
Wang R, Lu M, Zhang J, Chen S, Luo X, Qin Y, Chen H. Increased IL-10 mRNA expression in tumor-associated macrophage correlated with late stage of lung cancer. J Exp Clin Cancer Res. 2011 30:62