导师姓名： 娄加陶 专业代码： 100208
性别： 男 专业名称： 临床检验诊断学
培养单位： 附属胸科医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： 上海市淮海西路241号
邮编： ** 邮箱地址： loujiatao@126.com

研究方向 (点击浏览详细信息)
肺癌早期和个体化诊断的临床和基础研究

社会任职
上海市医师协会检验分会委员
上海市遗传学会分子诊断委员会副主任委员
上海市免疫学会肿瘤分会副主委
上海市医学会分子诊断分会副主任委员
中国中西医分会检验医学分会委员
中国抗癌协会肿瘤临床检验与伴随诊断专委会常委
中国医学装备协会检验医学分会常务委员
全国卫生产业企业管理协会实验医学专家委员会副主任委员
上海市免疫学会技术委员会委员兼秘书
上海市医学会检验医学分会常委兼秘书
全国卫生产业企业管理协会实验医学青年专家委员会主任委员
中国抗癌协会肿瘤标记物委员会常务委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
2019CXJQ03 肿瘤精准医学临床实践中的关键分子检测技术研发和转化运用 上海市卫计委协同创新集群项目 2019-01~2023-01 410万元 课题负责人
YJXT** 基于质谱流式技术的多组学、多靶标联合模型在肺部孤立性结节鉴别诊断中的临床应用研究 上海市胸科医院协同创新项目（重点项目） 2019-01~2021-12 50万元 课题负责人
16CR2011A 基于新型质谱芯片材料的早期肺癌代谢组学分析及临床诊断 上海申康临床三年行动计划项目 2017-06~2019-07 80万元 课题负责人
** IL-8：miRNA调控轴在肺癌骨转移中的功能机制研究 国家自然科学基金面上项目 2017-01~2020-12 53万元 课题负责人
2014DFA33010 肿瘤单细胞获取、生物特征与诊治相关合作研究 国家国际科技合作专项 2014-12~2017-11 185万元 课题参与人
SHDC** 外周血EGFR基因突变检测在肺癌个体化诊疗中临床应用 上海申康医院发展中心 2014-07~2017-06 10万元 课题负责人
2014YZDC10100 液体活检在早期肺癌诊断中的运用研究 院科技发展基金重大重点项目 2014-07~2017-06 27万元 课题负责人
** microRNA-101在炎症促进非小细胞肺癌中的作用和机制研究 国家自然科学基金面上项目 2014-01~2017-12 70万元 课题负责人
13JC** microRNA-101在炎症促进非小细胞肺癌中的作用和机制研究 上海市科委重点项目 2013-09~2016-08 20万元 课题负责人
特异性血清microRNA表达谱在肺腺癌早期诊断中的应用研究 上海市科委医学重点项目 2010-07~2013-09 20万元 课题负责人
09ZR** 肺癌患者血清microRNA表达谱的鉴定和应用研究 上海市科委自然基金项目 2009-08~2012-07 10万元 课题负责人
悬浮点阵技术在肿瘤靶向治疗筛查中的应用研究 上海市科委重点科技攻关项目 2009-07~2012-06 20万元 子课题负责人
07JC14053 肺部疾病快速诊断新技术的应用基础研究 上海市科委重点项目 2007-12~2009-11 20万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Xu W, Wang L, Zhang R, Sun X, Huang L, Su H, Wei X, Chen CC, Lou J （通讯作者）, Dai H, Qian K. Diagnosis and prognosis of myocardial infarction on a plasmonic chip. Nat Commun 2020 11(1):1654
Chen X, Wang L, Lou J. （通讯作者） Nanotechnology Strategies for the Analysis of Circulating Tumor DNA: A Review. Med Sci Monit. 2020 22;26:e921040
Lin Wang; Xiaomeng Hu; Qiaomei Guo; Xia Huang; Chia-hui Lin; Xiao Chen; Min Li; Qianqian Yao; Qianjun Zhou; Jianmin Wang; Shengrong Lin; Grace Zhao; Li Weng; Kun Qian; Jiatao Lou CLAmp-seq: a Novel Amplicon-based NGS Assay with Concatemer Error Correction for Improved Detection of Actionable Mutations in Plasma cfDNA from Patients with NSCLC Small Methods 2020 4, **
Zhou Q, Geng Q, Wang L, Huang J, Liao M, Li Y, Ding Z, Yang S, Zhao H, Shen Q, Pan C, Lou J （通讯作者）, Lu S, Chen C, Luo Q Value of folate receptor-positive circulating tumour cells in the clinical management of indeterminate lung nodules: A non-invasive biomarker for predicting malignancy and tumour invasiveness. EBioMedicine 2019 41:236-243
Chen X, Zhang DS, Wang L, Guo Q, Xu H, Lou J （通讯作者）, Gu H Multiplexed Detection of Mutant Circulating Tumor DNA Using Peptide Nucleic Acid Clamping Asymmetric Polymerase Chain Reaction and Liquidchip. J Biomed Nanotechnol 2019 15(7):1578-1588
Shihua Dong , Wei Li, Lin Wang , Jie Hu, Yuanlin Song , Baolong Zhang , Xiaoguang Ren , Shimeng Ji , Jin Li , Peng Xu , Ying Liang , Gang Chen , Jia-Tao Lou （通讯作者）, Wenqiang Yu Histone-Related Genes Are Hypermethylated in Lung Cancer and Hypermethylated HIST1H4F Could Serve as a Pan-Cancer Biomarker Cancer Res 2019 15;79(24):6101-6112.
Bai Y, Qu Y, Wu Z, Ren Y, Cheng Z, Lu Y, Hu J, Lou J, Zhao J, Chen C, Mao H Absolute quantification and analysis of extracellular vesicle lncRNAs from the peripheral blood of patients with lung cancer based on multi-colour fluorescence chip-based digital PCR. Biosens Bioelectron 2019 142:111523
Wang X, Deng Z, Huang C, Zhu T, Lou J, Wang L, Li Y Differential N-glycan patterns identified in lung adenocarcinoma by N-glycan profiling of formalin-fixed paraffin-embedded (FFPE) tissue sections. J Proteomics 2018 172:1-10
Sun X, Huang L, Zhang R, Xu W, Huang J, Gurav DD, Vedarethinam V, Chen R, Lou J, Wang Q, Wan J, Qian K. Metabolic Fingerprinting on a Plasmonic Gold Chip for Mass Spectrometry Based in Vitro Diagnostics. ACS Cent Sci 2018 Feb 28;4(2):223-229
Guo Q, Wang J, Xiao J, Wang L, Hu X, Yu W, Song G, Lou J （通讯作者）, Chen J. Heterogeneous mutation pattern in tumor tissue and circulating tumor DNA warrants parallel NGS panel testing. Mol Cancer 2018 Aug 28;17(1):131
Liu D, Zhou H, Shi D, Shen S, Tian Y, Wang L, Lou J, Cong R, Lu J, Zhang H, Zhao M, Zhu S, Cao Z, Jin R, Wang Y, Zhang X, Yang G, Wang Y, Zhang C Quality Control of Next-generation Sequencing-based In vitro Diagnostic Test for Onco-relevant Mutations Using Multiplex Reference Materials in Plasma J cancer 2018 Apr 18;9(9):1680-1688
Wang L, Guo Q, Yu W, Qiao L, Zhao M, Zhang C, Hu X, Yang G, Xiong L, Lou J （通讯作者） Quantification of plasma EGFR mutations in patients with lung cancers: Comparison of the performance of ARMS-Plus and droplet digital PCR. Lung Cancer 2017 114:31-37
Lin Wang, Chuanyong Wu, Lihua Qiao, Qiaomei Guo, Mingna Zhao, Guohua Yang, Jiatao Lou （通讯作者） Clinical Significance of Folate Receptor-positive Circulating TumorCells Detected by Ligand-targeted Polymerase Chain Reaction in Lung Cancer J Cancer 2017 8(1):104-110
Zhang L, Huang Q, Lou J, Zou L, Wang Y, Zhang P, Yang G, Zhang J, Yu L, Yan D, Zhang C, Qiao J, Wang S, Wang S, Xu Y, Ji H, Chen Z, Zhang Z. A novel PHD-finger protein 14/KIF4A complex overexpressed in lung cancer is involved in cell mitosis regulation and tumorigenesis. Oncotarget 2017 DOI: 10.18632/oncotarget.14962
Zhang C, Yu W, Wang L, Zhao M, Guo Q, Lv S, Hu X, Lou J. （通讯作者） DNA Methylation Analysis of the SHOX2 and RASSF1A Panel in Bronchoalveolar Lavage Fluid for Lung Cancer Diagnosis. J Cancer 2017 8(17):3585-359
Zhao M, Zhang L, Lv S, Zhang C, Wang L, Chen H, Zhou Y, Lou J （通讯作者） IQGAP1 Mediates Hcp1-Promoted Escherichia coli Meningitis by Stimulating the MAPK Pathway. Front Cell Infect Microbiol 2017 19;7:132
Lou J, Zhang L, Lv S, Zhang C, Jiang S. Biomarkers for Hepatocellular Carcinoma. Biomark Cancer 2017 28;9:1-9
Shaogang Lv, Jian Xue, Chuanyong Wu, Lin Wang, Jing Wu, ShujunXu, Xiaohui Liang,Jiatao Lou （通讯作者） Identification of A Panel of Serum microRNAs as Biomarkers for Early Detection of Lung Adenocarcinoma. J Cancer 2017 8(1):48-56
Wu J, Wei X, Gan J, Huang L, Shen T, Lou J, Liu B, Zhang JX, Qian K Multifunctional Magnetic Particles for Combined Circulating Tumor Cells Isolation and Cellular Metabolism Detection Adv Funct Mater 2016 26(22):4016-4025.
Bin Liu, Yaling Li, Hao Wan, Lin Wang, Wei Xu, Shoujun Zhu, Yongye Liang, Bo Zhang, Jiatao Lou （通讯作者）, Hongjie Dai, Kun Qian High performance multiplexed lung cancer biomarkers detection on a plasmonic gold chip Adv Funct Mater 2016 26:7994-8002
Fei Wu, Lin Wang, Qiaomei Guo, Minga Zhao, Hongchen Gu, Hong Xu, Jiatao Lou （通讯作者） A homogeneous immunoassay method for detecting Interferon-gamma in patients with latent tuberculosis infection. J Microbiol Biotechnol 2016 26(3):588-95
Li YL, Wang J, Zhang CY, Shen YQ, Wang HM, Ding L, Gu YC, Lou JT, Zhao XT, Ma ZL, Jin YX. MiR-146a-5p inhibits cell proliferation and cell cycle progression in NSCLC cell lines by targeting CCND1 and CCND2. Oncotarget 2016 7(37):59287-59298
Yuqing Zhang,Xiaojia Ye,Gengxin Xu,Xiulong Jin,Mengmeng Luan,Jiatao Lou,Lin Wang,Chengjun Huangd,Jian Ye Identification and distinction of non-small-cell lung cancer cells by intracellular SERS nanoprobes RSC Advances 2016 6, 5401–5407
Zhang LF, Lou JT, Lu MH, Gao C, Zhao S, Li B, Liang S, Li Y, Li D, Liu MF Suppression of miR-199a maturation by HuR is crucial for hypoxia-induced glycolytic switch in hepatocellular carcinoma. EMBO J. 2015 34(21):2671-85
Zhong-Liang Ma, Pin-Pin Hou, Yan-Li Li, De-Tao Wang, Tian-Wei Yuan, Jia-Li Wei, Bo-Tao Zhao, Jia-Tao Lou, Xin-Tai Zhao, Yan Jin, You-Xin Jin MicroRNA-34a inhibits the proliferation and promotes the apoptosis of non-small cell lung cancer H1299 cell line by targeting TGFβR2 Tumor Biology 2015 36(4):2481-90
Chen X, Xu Y, Yu J, Li J, Zhou X, Wu C, Ji Q, Ren Y, Wang L, Huang Z, Zhuang H, Piao L, Head R, Wang Y, Lou J （通讯作者） Antigen detection based on background fluorescence quenching immunochromatographic assay. Analytica Chimica Acta 2014 842(2):44-50
Wang L, Zhang LF, Wu J, Xu SJ, Xu YY, Li D, Lou JT （通讯作者）, Liu MF IL-1β-Mediated Repression of microRNA-101 Is Crucial for Inflammation-Promoted Lung Tumorigenesis. Cancer Research 2014 74(17):4720-30
Shi Y, Liu X, Lou J, Han X, Zhang L, Wang Q, Li B, Dong M, Zhang Y Plasma levels of heat shock protein 90 alpha associated with lung cancer development and treatment responses Clin Cancer Res 2014 20(23):6016-22
Lou J, Ben S, Yang G, Liang X, Wang X, Ni S, Han B Quantification of rare circulating tumor cells in non-small cell lung cancer by ligand-targeted PCR. PLoS One 2013 8(12):80-458
Jiatao Lou （通讯作者）,Jian Xue,Qiang Lin Transcriptome-wide Network Analysis of Squamous Lung Cancer Reveals Potential Methylation Genes APJCP 2011 12 (9) :2347-2350