导师姓名： 李彦欣 专业代码： 100214
性别： 女 专业名称： 肿瘤学
培养单位： 附属儿童医学中心 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式：
邮编： 200127 邮箱地址： liyanxin@scmc.com.cn

研究方向 (点击浏览详细信息)
细胞治疗在血液肿瘤中的应用研究
儿童血液以及实体肿瘤增殖和干性维持的分子机制

社会任职

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** TRIM24在MYCN调控的高危儿童神经母细胞瘤增殖中的作用及机制 国家自然基金面上项目 2020-10~2023-12 55万元 课题负责人
2018YFC** 高危神经母细胞瘤发生、复发及转移的分子基础研究 重大慢性非传染性疾病防控研究 2018-01~2020-12 1200万元 课题参与人
** 泛素连接酶TRIM59调控胶质瘤发生发展的分子机制 国家自然基金面上项目 2018-01~2022-12 55万元 课题负责人
YG2017MS32 泛素连接酶在肿瘤及肿瘤干细胞中的作用 “医工交叉研究基金” 2018-01~2020-12 21万元 课题负责人
TM201502 白血病PRPS2耐药机制研究以及抗耐药先导物发现和优化 交大医学院转化医学协同创新合作研究项目 2016-01~2018-12 35万元 课题负责人
** 利用iPS技术研究复发T-细胞急性淋巴细胞白血病（T-ALL）细胞亚克隆中基因变异特征及其耐药复发机制 国家自然科学基金面上项目 2015-01~2018-12 70万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Yang Li#, Ting Li#, Yuejia Tang#, Zhiyan Zhan, Lixia Ding, Lili Song, Tingting Yu, Yi Yang, Jing Ma, Yingwen Zhang, Ying Zhou, Song Gu, Min Xu*, Yijin Gao*, Yanxin Li* （通讯作者） The function of a heterozygous p53 mutation in a Li-Fraumeni syndrome patient Plos One 2020 9;15(6):e**
Ting Li*, Lili Song*, Yingwen Zhang*, Yali Han*, Zhiyan Zhan, Zhou Xv, Yang Li, Yuejia Tang, Yi Yang, Siqi Wang, Shanshan Li, Liang Zheng#, Yanxin Li# （通讯作者）, Yijin Gao# Molecular mechanism of c-Myc and PRPS1/2 against thiopurine resistance in Burkitt's lymphoma Journal of cellular and molecular medicine 2020 11. doi: 10.1111/jcmm.15322
Yinfang Wang, Yanli Hou, Weiwei Zhang, Angel A. Alvarez, Yongrui Bai, Bo Hu, Shi-Yuan Cheng, Kun Yang*, Yanxin Li* （通讯作者）, and Haizhong Feng* Lipolytic inhibitor G0S2 modulates glioma stem-like cell radiation response Journal of Experimental & Clinical Cancer Research 2019 38:147
Youzhou Sang# , Yanli Hou# , Rongrong Cheng, Liang Zheng, Angel A. Alvarez, Bo Hu, Shi-Yuan Cheng, Weiwei Zhang* , Yanxin Li* （通讯作者）, and Haizhong Feng* Targeting PDGFR -activated Glioblastoma through Specific Inhibition of SHP-2-mediated Signaling Neuro Oncol 2019 doi: 10.1093/neuonc/noz107
Zhiyan Zhan#, Lili Song#, Weiwei Zhang#, Haihui Gu, Haizi Cheng, Yingwen Zhang, Yi Yang, Guangzhen Ji , Haizhong Feng*, Tao Cheng* and Yanxin Li* Absence of cyclin-dependent kinase inhibitor p27 or p18 increases efficiency of iPSC generation without induction of iPSC genomic instability Cell Death & Desease 2019 https://doi.org/10.1038/s41419-019-1502-8
Cai Jiaoyang#, Huang Xia#, Yin Minzhi#, Pa Ci, Song Lili, Zhan Zhiyan, Chen Jing, Gao Yijin, Tang Jingyan, Li Yanxin* （通讯作者）, Shen Shuhong* A novel fusion gene PLEKHA6-NTRK3 in langerhans cell histiocytosis International Journal of Cancer 2019 144(1):117-124
Jianming Tang, Yanxin Li* （通讯作者）, Youzhou Sang, Bo Yu, Deguan Lv, Weiwei Zhang, and Haizhong Feng* LncRNA PVT1 regulates triple-negative breast cancer through KLF5/beta-catenin signaling Oncogene 2018 oi.org/10.1038/s41388-018-0310-4
HAIHUI GU#; Xia Huang#; JING XU#; LILI SONG; SHUPING LIU; XIAO-BING ZHANG; WEIPING YUAN; Yanxin Li* Optimizing the method for generation of integration-free induced pluripotent stem cells from human peripheral blood Stem Cell Research & Therapy 2018 10.1186/s13287-018-0908-z.
Youzhou Sang#, Yanxin Li* （通讯作者）,#, Lina Song#, Angel A. Alvarez#, Weiwei Zhang, Deguan Lv, Jianming Tang, Feng Liu, Zhijie Chang, Shigetsugu Hatakeyama, Bo Hu, Shi-Yuan Cheng, and Haizhong Feng* TRIM59 promotes gliomagenesis by inhibiting TC45 dephosphorylation of STAT3 Cancer Res 2018 10.1158/0008-5472.CAN-17-2774
Deguan Lv#, Yanxin Li# （共同第一作者）, Weiwei Zhang, Angel A. Alvarez, Lina. Song, Jianming Tang, Wei-Qiang Gao, Bo Hu, Shi-Yuan Cheng, Haizhong Feng* TRIM24 is an oncogenic transcriptional co-activator of STAT3 in glioblastoma Nat Commun. 2017 doi: 10.1038 /s41467 -017- 01731-w
Deguan Lv#, Feng Jia#, Yanli Hou#,Youzhou Sang, Angel A. Alvarez,Weiwei Zhang,Wei-Qiang Gao, Bo Hu, Shi-Yuan Cheng, Jianwei Ge*,Yanxin Li （通讯作者）,* and Haizhong Feng* Histone Acetyltransferase KAT6A Upregulates PI3K/AKT Signaling through TRIM24 Binding Cancer Research 2017 77(22):6190-6201
Lei Zhang(#) ,Weiwei Zhang(#),Yanxin Li (#) （共同第一作者）,Angel Alvarez,Zuoqing Li, Yinfang Wang,Lina Song,Deguan Lv,Ichiro Nakano,Bo Hu,Shi-Yuan Cheng, Haizhong Feng* SHP-2 upregulated ZEB1 is important for PDGFR alpha driven glioma epithelial-mesenchymal transition and invasion in mice and humans Oncogene 2016 doi:10.1038
Feng H#, Li Y# （共同第一作者）, Yin Y#, Zhang W, Hou Y, Zhang L, Li Z, Xie B, Gao WQ, Sarkaria JN, Raizer JJ, James CD, Parsa AT, Hu B, Cheng SY Protein kinase A-dependent phosphorylation of Dock180 at serine residue 1250 is important for glioma growth and invasion stimulated by platelet derived growth factor receptor α. Neuro Oncol 2015 17(6):832-42
Yanxin Li, Haizhong Feng, Haihui Gu, Dale W. Lewis, Youzhong Yuan, Lei Zhang, Hui Yu, Peng Zhang, Haizi Cheng, Weimin Miao, Weiping Yuan, Shi-Yuan Cheng, Susanne M. Gollin, and Tao Cheng The p53-PUMA axis suppresses iPSC generation Nature Communications 2013 4:1-9
Yanxin Li, Rekha Pal, Li-Ying Sung, Haizhong Feng, Weimin Miao, Shi-Yuan Cheng, Cindy Tian and Tao Cheng An opposite effect of the CDK inhibitor, p18INK4c on embryonic stem cells compared with tumor and adult stem cells Plos One 2012 7(9):1-10