导师姓名： 刘宇 专业代码： 100214
性别： 男 专业名称： 肿瘤学
培养单位： 附属儿童医学中心 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： 上海市浦东新区东方路1678号医疗科教楼868室
邮编： 200127 邮箱地址： liuyu@scmc.com.cn

研究方向 (点击浏览详细信息)
计算生物学与儿童肿瘤基因组学

社会任职
中国环境诱变剂学会生物标志物专业委员会委员
Leukemia杂志审稿人

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 儿童急性淋巴细胞白血病中非编码体细胞变异的计算生物学分析及功能研究 国家自然科学基金面上项目 2020-01~2023-12 58万元 课题负责人
02 儿童肿瘤基因组学研究及临床转化 上海交通大学医学院“临床专职科研队伍”项目 2019-10~2022-09 100万元 课题负责人
01 上海市海外高层次人才项目 上海市教委 2019-01~2021-12 100万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Li B, Brady SW, Ma X, Shen S, Zhang Y, Li Y, Szlachta K, Dong L, Liu Y, Yang F, Wang N, Flasch DA, Myers MA, Mulder HL, Ding L, Liu Y, Tian L, Hagiwara K, Xu K, Zhou X, Sioson E, Wang T, Yang L, Zhao J, Zhang H, Shao Y, Sun H, Sun L, Cai J, Sun HY, Lin TN, Du L, Li H, Rusch M, Edmonson MN, Easton J, Zhu X, Zhang J, Cheng C, Raphael BJ, Tang J, Downing JR, Alexandrov LB, Zhou BS, Pui CH, Yang JJ, Zhang J. Therapy-induced mutations drive the genomic landscape of relapsed acute lymphoblastic leukemia. Blood 2020 135(1):41-55
Yu Liu#* （通讯作者）, Chunliang Li#, Shuhong Shen#, Xiaolong Chen, Karol Szlachta, Michael N Edmonson, Ying Shao, Xiaotu Ma, Judith Hyle, Shaela Wright, Bensheng Ju, Michael C Rusch, Yanling Liu, Benshang Li, Michael Macias, Liqing Tian, John Easton, Maoxiang Qian, Jun J Yang, Shaoyan Hu, A Thomas Look, Jinghui Zhang*. Discovery of Regulatory Noncoding Variants in Individual Cancer Genomes by Using cis-X. Nature Genetics 2020 10.1038/s41588-020-0659-5. Online ahead of print.
Zimmerman MW#, Liu Y# （共同第一作者）, He S, Durbin AD, Abraham BJ, Easton J, Shao Y, Xu B, Zhu S, Zhang X, Li Z, Weichert-Leahey N, Young RA*, Zhang J*, Look AT*. MYC drives a subset of high-risk pediatric neuroblastomas and is activated through mechanisms including enhancer hijacking and focal enhancer amplification. Cancer Discovery 2018 8(3):320-335
Ma X#, Liu Yu# （共同第一作者）, Liu Yanling, Alexandrov LB, Edmonson MN, Gawad C, Zhou X, Li Y, Rusch MC, Easton J, Huether R, Gonzalez-Pena V, Wilkinson MR, Hermida LC, Davis S, Sioson E, Pounds S, Cao X, Ries RE, Wang Z, Chen X, Dong L, Diskin SJ, Smith MA, Guidry Auvil JM, Meltzer PS, Lau CC, Perlman EJ, Maris JM, Meshinchi S, Hunger SP, Gerhard DS, Zhang J*. Pan-cancer genome and transcriptome analyses of 1,699 pediatric leukemias and solid tumors. Nature 2018 555(7696):371-376
Bolouri H#*, Farrar JE#, Triche T Jr#, Ries RE#, Lim EL, Alonzo TA, Ma Y, Moore R, Mungall AJ, Marra MA, Zhang J, Ma X, Liu Y, Liu Y, Auvil JMG, Davidsen TM, Gesuwan P, Hermida LC, Salhia B, Capone S, Ramsingh G, Zwaan CM, Noort S, Piccolo SR, Kolb EA, Gamis AS, Smith MA, Gerhard DS, Meshinchi S*. The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions. Nature Medicine 2018 24(1):103-112
Liu Y, Easton J, Shao Y, Maciaszek J, Wang Z, Wilkinson MR, McCastlain K, Edmonson M, Pounds SB, Shi L, Zhou X, Ma X, Sioson E, Li Y, Rusch M, Gupta P, Pei D, Cheng C, Smith MA, Auvil JG, Gerhard DS, Relling MV, Winick NJ, Carroll AJ, Heerema NA, Raetz E, Devidas M, Willman CL, Harvey RC, Carroll WL, Dunsmore KP, Winter SS, Wood BL, Sorrentino BP, Downing JR, Loh ML, Hunger SP*, Zhang J*, Mullighan CG*. The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia. Nature Genetics 2017 49(8):1211-1218
Abraham BJ, Hnisz D, Weintraub AS, Kwiatkowski N, Li CH, Li Z, Weichert-Leahey N, Rahman S, Liu Y, Etchin J, Li B, Shen S, Lee TI, Zhang J, Look AT*, Mansour MR*, Young RA*. Small genomic insertions form enhancers that misregulate oncogenes. Nature Communications 2017 8:14385
Li Z, Abraham BJ, Berezovskaya A, Farah N, Liu Y, Leon T, Fielding A, Tan SH, Sanda T, Weintraub AS, Li B, Shen S, Zhang J, Mansour MR*, Young RA*, Look AT*. APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL. Leukemia 2017 31(10):2057–2064
Reshmi SC#, Harvey RC#, Roberts KG#, Stonerock E, Smith A, Jenkins H, Chen IM, Valentine M, Liu Y, Li Y, Shao Y, Easton J, Payne-Turner D, Gu Z, Tran TH, Nguyen JV, Devidas M, Dai Y, Heerema NA, Carroll AJ 3rd, Raetz EA, Borowitz MJ, Wood BL, Angiolillo AL, Burke MJ, Salzer WL, Zweidler-McKay PA, Rabin KR, Carroll WL, Zhang J, Loh ML*, Mullighan CG*, Willman CL*, Gastier-Foster JM*, Hunger SP*. Targetable kinase gene fusions in high-risk B-ALL: a study from the Children's Oncology Group. Blood 2017 129(25):3352-3361
Zhang J*, McCastlain K, Yoshihara H, Xu B, Chang Y, Churchman ML, Wu G, Li Y, Wei L, Iacobucci I, Liu Y, Qu C, Wen J, Edmonson M, Payne-Turner D, Kaufmann KB, Takayanagi SI, Wienholds E, Waanders E, Ntziachristos P, Bakogianni S, Wang J, Aifantis I, Roberts KG, Ma J, Song G, Easton J, Mulder HL, Chen X, Newman S, Ma X, Rusch M, Gupta P, Boggs K, Vadodaria B, Dalton J, Liu Y, Valentine ML, Ding L, Lu C, Fulton RS, Fulton L, Tabib Y, Ochoa K, Devidas M, Pei D, Cheng C, Yang J, Evans WE, Relling MV, Pui CH, Jeha S, Harvey RC, Chen IL, Willman CL, Marcucci G, Bloomfield CD, Kohlschmidt J, Mrózek K, Paietta E, Tallman MS, Stock W, Foster MC, Racevskis J, Rowe JM, Luger S, Kornblau SM, Shurtleff SA, Raimondi SC, Mardis ER, Wilson RK, Dick JE, Hunger SP, Loh ML, Downing JR, Mullighan CG*; St. Jude Children's Research Hospital–Washington University Pediatric Cancer Genome Project. Deregulation of DUX4 and ERG in acute lymphoblastic leukemia. Nature Genetics 2016 48(12):1481-1489
Liu Y#, Zhang J#, Li L#, Yin G#, Zhang J#, Zheng S, Cheung H, Wu N, Lu N, Mao X, Yang L, Zhang J, Zhang L, Seth S, Chen H, Song X, Liu K, Xie Y, Zhou L, Zhao C, Han N, Chen W, Zhang S, Chen L, Cai W, Li L, Shen M, Xu N, Cheng S, Yang H, Lee JJ, Correa A, Fujimoto J, Behrens C, Chow CW, William WN, Heymach JV, Hong WK, Swisher S, Wistuba II, Wang J, Lin D, Liu X, Futreal PA*, Gao Y*. Genomic heterogeneity of multiple synchronous lung cancer. Nature Communications 2016 7:13200
Zhou X, Edmonson MN, Wilkinson MR, Patel A, Wu G, Liu Y, Li Y, Zhang Z, Rusch MC, Parker M, Becksfort J, Downing JR, Zhang J*. Exploring genomic alteration in pediatric cancer using ProteinPaint. Nature Genetics 2016 48(1):4-6
Cao Y#, Liu Y# （共同第一作者）, Yang X, Liu X, Han N, Zhang K, Lin D*. Estimation of the survival of patients with lung squamous cell carcinoma using genomic copy number aberrations. Clinical Lung Cancer 2016 17(1):68-74 e65
Faber ZJ#, Chen X#, Gedman AL#, Boggs K, Cheng J, Ma J, Radtke I, Chao JR, Walsh MP, Song G, Andersson AK, Dang J, Dong L, Liu Y, Huether R, Cai Z, Mulder H, Wu G, Edmonson M, Rusch M, Qu C, Li Y, Vadodaria B, Wang J, Hedlund E, Cao X, Yergeau D, Nakitandwe J, Pounds SB, Shurtleff S, Fulton RS, Fulton LL, Easton J, Parganas E, Pui CH, Rubnitz JE, Ding L, Mardis ER, Wilson RK, Gruber TA, Mullighan CG, Schlenk RF, Paschka P, D?hner K, D?hner H, Bullinger L*, Zhang J*, Klco JM*, Downing JR*. The genomic landscape of core-binding factor acute myeloid leukemias. Nature Genetics 2016 48(12):1551-1556
Li L#, Tan J#, Zhang Y, Han N, Di X, Xiao T, Cheng S, Gao Y*, Liu Y*. （通讯作者） DLK1 promotes lung cancer cell invasion through upregulation of MMP9 expression depending on Notch signaling. Plos One 2014 9(3):e91509
Wu C, Hu Z, He Z, Jia W, Wang F, Zhou Y, Liu Z, Zhan Q, Liu Y, Yu D, Zhai K, Chang J, Qiao Y, Jin G, Liu Z, Shen Y, Guo C, Fu J, Miao X, Tan W, Shen H, Ke Y, Zeng Y, Wu T, Lin D. Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. Nature Genetics 2011 43(7):679-84
Liu Y, Lin D, Xiao T, Ma Y, Hu Z, Zheng H, Zheng S, Liu Y, Li M, Li L, Cao Y, Guo S, Han N, Di X, Zhang K, Cheng S, Gao Y. An immunohistochemical analysis-based decision tree model for estimating the risk of lymphatic metastasis in pN0 squamous cell carcinomas of the lung. Histopathology 2011 59(5):882-91