导师姓名： 王筱霞 专业代码： 100201
性别： 女 专业名称： 内科学
培养单位： 附属同仁医院 三级学科/
专业领域： 肾病
导师类型： 博士生导师 专业学位导师： 兼
联系方式： 工作手机：**
邮编： 200336 邮箱地址： Omaha198501@163.com

研究方向 (点击浏览详细信息)
代谢性肾病：表观遗传学在糖尿病肾病中的作用及分子机制

社会任职
国家自然科学基金同行评议专家
上海市医师协会肾脏内科医师分会委员
上海市医学会肾脏内科专科分会委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** LncRNA-Gm26749作为ceRNA调控miR-196a-5p介导糖尿病肾病系膜细胞肥大的机制研究 国家自然科学基金委 2018-01~2021-12 56万元 课题负责人
** MicroRNA-195通过靶向抑制SLC2A3干扰足细胞葡萄糖摄取并导致足细胞损伤的机制研究 国家自然科学基金委 2014-01~2016-12 25万元 课题参与人
** MiR-26b 在糖尿病肾病系膜细胞肥大中异常表达的机制及功能研究 国家自然科学基金委 2013-01~2016-12 70万元 课题负责人
MicroRNAs靶向GSK3beta参与糖尿病肾病系膜细胞肥大的机制研究 上海市科委非政府间国际合作项目 2011-10~2013-10 25万元 课题参与人
CJ2009 TRPC6在糖尿病系膜细胞氧化应激中的机制及GSPD保护作用的研究 国家人事部留学归国人员基金 2009-09~2011-08 8万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Wang YZ, Zhu DY, Zhang N, Wang YL, Ding M, Xie XM, Shen E, Wang XX. （通讯作者） Identification of EA15, MIR22, LINC00472 as potential diagnostic markers for Diabetic Kidney Disease. J Cell Physiol 2019 234(6): 8797-8803.
Miao N, Yin F, Xie H, Wang Y, Xu Y, Shen Y, Xu D, Yin J, Wang B, Zhou Z, Cheng Q, Chen P, Xue H, Zhou L, Liu J, Wang X （通讯作者）, Zhang W, Lu L. The cleavage of gasdermin D by caspase-11 promotes tubular epithelial cell pyroptosis and urinary IL-18 excretion in acute kidney injury. Kidney Int. 2019 96(5):1105-1120.
Sun L, Ji Y, Wang Y, Zhu D, Chen F, Zhang N, Shen E, Wang X （通讯作者） Development and validation of a prediction model to estimate the probability of left-ventricular diastolic dysfunction stable maintenance hemodialysis patients without clinical heart failure. Nephron . 2019 2:1-10
Linlin Sun, Yongqiang Ji, YonglanWang, Miao Ding, Xinmiao Xie, Dingyu Zhu,Fuhua Chen, Nan Zhang, Xiaoxia Wang. （通讯作者） High-sensitive cardiac troponin T: a biomarker of left-ventricular diastolic dysfunction in hemodialysis patients; J Nephrol 2018 31(6):967-973
Miao N, Wang B, Xu D, Wang Y, Gan X, Zhou L, Xue H, Zhang W, Wang X （通讯作者）, Lu L. Caspase-11 promotes cisplatin-induced renal tubular apoptosis through a caspase-3-dependent pathway. Am J Physiol Renal Physiol. 2018 314(2): F269-F279
Wang YZ, Xu WW, Zhu DY, Zhang N, Wang YL, Ding M, Xie XM, Sun LL, Wang XX. （通讯作者） Specific expression network analysis of diabetic nephropathy kidney tissue revealed key methylated sites. J Cell Physiol. 2018 233(10):7139-7147.
Wang X, Shen E, Wang Y, Li J, Cheng D, Chen Y, Gui D, Wang N Cross talk between miR-214 and PTEN attenuates glomerular hypertrophy under diabetic conditions. Sci Rep. 2016 6: 31506.
Kong YL, Shen Y, Ni J, Shao DC, Miao NJ, Xu JL, Zhou L, Xue H, Zhang W, Wang XX （通讯作者）, （共同通讯作者）Lu LM. Insulin deficiency induces rat renal mesangial cell dysfunction via activation of IGF-1/IGF-1R pathway Acta Pharmacol Sin. 2016 37(2): 217-27
Wang X, Shen E, Wang Y, Jiang Z, Gui D, Cheng D, Chen T, Wang N MiR-196a Regulates High Glucose-Induced Mesangial Cell Hypertrophy by Targeting p27kip1 J Lab Autom. 2015 20(4): 491-9
Cheng D, Fei Y, Liu Y, Li J, Xue Q, Wang X, Wang N HbA1C variability and the risk of renal status progression in Diabetes Mellitus: a meta-analysis PLoS One 2014 9(12): e115509
Cheng D, Fei Y, Liu Y, Li J, Chen Y, Wang X, Wang N Efficacy and safety of dipeptidyl peptidase-4 inhibitors in type 2 diabetes mellitus patients with moderate to severe renal impairment: a systematic review and meta-analysis. PLoS One. 2014 9(10):e111543
Chen YQ, Wang XX, Yao XM, Zhang DL, Yang XF, Tian SF, Wang NS Abated microRNA-195 expression protected mesangial cells from apoptosis in early diabetic renal injury in mice. J Nephrol 2012 25 (4):566-576
Chen YQ, Wang XX （共同第一作者）, Yao XM, Zhang DL, Yang XF, Tian SF, Wang NS MicroRNA-195 Promotes Apoptosis in Mouse Podocytes via Enhanced Caspase Activity Driven by BCL2 Insufficiency Am J Nephrol 2011 34(6):549-559
Shen E, Diao X, Wang XX, Chen R, Hu B MicroRNAs involved in the mitogen-activated protein kinase cascades pathway during glucose-induced cardiomyocyte hypertrophy. Am J Pathol 2011 179(2):639-50
王筱霞, 陈玉强,汪年松 Rac1抑制剂上调糖尿病小鼠肾小球nephrin的表达 中国中西医结合肾病杂志 2010 11(7):592-594
王筱霞,陈玉强,汪年松 糖尿病肾病早期miRNAs表达谱分析 中国中西医结合肾病杂志 2010 11(8):681-683
Wang XX, Pluznick JL, Settles DC, Sansom SC Association of VASP with TRPC4 in PKG-mediated inhibition of the store-operated calcium response in mesangial cells Am J Physiol Renal Physiol 2007 293(6):1768-1776
Wang X, Pluznick JL, Wei P, Padanilam BJ, Sansom SC TRPC4 forms store-operated Ca2+ channels in mouse mesangial cells Am J Physiol Cell Physiol 2004 287(2):C357-64