导师姓名： 王玉刚 专业代码： 100201
性别： 男 专业名称： 内科学
培养单位： 附属同仁医院 三级学科/
专业领域： 消化系病
导师类型： 博士生导师 专业学位导师： 兼
联系方式： **
邮编： 200336 邮箱地址： wang_yugang@sina.com

研究方向 (点击浏览详细信息)
消化系统肿瘤发生的分子机制和综合诊治

社会任职
中国医促会消化病分会委员
上海市医学会消化病分会委员
上海市医学会消化病分会肠道微生物及HP学组委员
中国生理学会消化与营养专业委员会委员
上海市医学会肝病分会自身免疫性肝病学组委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
低pH环境通过下调外泌体CD280强化肿瘤细胞内吞促进Ori-AlPcS-Exo发挥多级靶向抗胃癌的研究 国家自然科学基金面上项目 2019-01~2022-12 54万元 课题负责人
ZK2015A24 上海市医学重点专科A类 上海市卫计委 2015-12~2018-12 100万元 课题负责人
** 基于HATs靶点的天然小分子化合物LXD-070抗胃癌机制研究 国家自然科学基金面上项目 2015-01~2018-12 70万元 课题负责人
YXMZK003 医学名专科-消化内科 上海市长宁区卫计委 2015-01~2018-12 10万元 课题负责人
2015C01 长宁区创新团队 上海市长宁区科委 2014-12~2017-12 50万元 课题负责人
14ZR** 以HATs为靶点抑制胃癌的天然小分子化合物的筛选及机制研究 上海科委自然基金 2014-08~2017-08 30万元 课题负责人
ZK2012A05 上海市医学重点专科A类 上海市卫计委 2012-10~2015-10 100万元 课题负责人
2011QZB02 慢性肝病综合诊治 上海市长宁区卫计委 2012-01~2015-12 10万元 课题负责人
2011R01 长宁区创新孵化团队 上海市长宁区科委 2011-01~2014-12 15万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Wang YG, Wang T, Shi M, Zhai B. Long noncoding RNA EPB41L4A-AS2 inhibits hepatocellular carcinoma development by sponging miR-301a-5p and targeting FOXL1. J Exp Clin Cancer Res. 2019 38(1):153.
Wang YG, Zheng DH, Shi M, Xu XM. T cell dysfunction in chronic hepatitis B infection and liver cancer: evidence from transcriptome analysis. J Med Genet. 2019 56(1):22-28.
Wu Q, Shi M, Meng W, Wang Y （通讯作者）, Hui P, Ma J. Long noncoding RNA FOXD3-AS1 promotes colon adenocarcinoma progression and functions as a competing endogenous RNA to regulate SIRT1 by sponging miR-135a-5p. J Cell Physiol. 2019 234(12):21889-21902.
Wang YG, Wang T, Ding M, Xiang SH, Shi M, Zhai B. hsa_circ_** acts as a ceRNA to suppress hepatocellular cancer progression by sponging hsa-miR-1307. Cancer Lett. 2019 2019 Sep 28;460:128-138.
Shi M, Jiang Y, Yang L, Yan S, Wang YG （通讯作者）, Lu XJ. Decreased levels of serum exosomal miR-638 predict poor prognosis in hepatocellular carcinoma. J Cell Biochem 2018 119(6):4711-4716.
Wu Q, Xiang S, Ma J, Hui P, Wang T, Meng W, Shi M, Wang Y. （通讯作者） Long non-coding RNA CASC15 regulates gastric cancer cell proliferation,migration and epithelial mesenchymal transition by targeting CDKN1A and ZEB1. Mol Oncol. 2018 12(6):799-813.
Xu L, Gong C, Li G, Wei J, Wang T, Meng W, Shi M, Wang Y. （通讯作者） Ebselen suppresses inflammation induced by Helicobacter?pylori lipopolysaccharide via the p38 mitogen-activated protein kinase signaling pathway. Mol Med Rep 2018 17(5):6847-6851.
Shi M, Zhang XY, Yu H, Xiang SH, Xu L, Wei J, Wu Q, Jia R, Wang YG （通讯作者）, Lu XJ. DDX11-AS1 as potential therapy targets for human hepatocellular carcinoma. Oncotarget 2017 8(27):44195-44202.
Deng Y, Chen C, Yu H, Diao H, Shi C, Wang Y, Li G, Shi M. Oridonin ameliorates lipopolysaccharide/D-galactosamine-induced acute liver injury in mice via inhibition of apoptosis. Am J Transl Res. 2017 9(9):4271-4279
Xu L, Dai W, Li J, He L, Wang F, Xia Y, Chen K, Li S, Liu T, Lu J, Zhou Y,Wang Y, Guo C. Methylation-regulated miR-124-1 suppresses tumorigenesis in hepatocellular carcinoma by targeting CASC3. Oncotarget. 2016 7(18): 26027-26041.
Xue HY, Zhang X, Wang Y （共同第一作者）, Xiaojie L, Dai WJ, Xu Y. In vivo gene therapy potentials of CRISPR-Cas9. Gene Ther. 2016 23(7):557-9.
Yu CB, Zhu LY, Wang YG （共同第一作者）, Li F, Zhang XY, Dai WJ. Systemic transcriptome analysis of hepatocellular carcinoma. Systemic transcriptome analysis of hepatocellular carcinoma. Tumour Biol. 2016 26: 1-9.
Shi M, Lu XJ, Zhang J, Diao H, Li G, Xu L, Wang T, Wei J, Meng W, Ma JL, Yu H,Wang YG. （通讯作者） Oridonin, a novel lysine acetyltransferases inhibitor, inhibits proliferation and induces apoptosis in gastric cancer cells through p53- and caspase-3-mediated mechanisms. Oncotarget. 2016 19;7(16):22623-31.
Wang YG, Xu L, Jia RR, Wu Q, Wang T, Wei J, Ma JL, Shi M, Li ZS. DDR2 Induces Gastric Cancer Cell Activities via Activating mTORC2 Signaling and Is Associated with Clinicopathological Characteristics of Gastric Cancer. Dig Dis Sci. 2016 61(8):2272-83.
Shi M, Wei J, Meng WY, Wang N, Wang T, Wang YG. （通讯作者） Effects of phased joint intervention on Rho/ROCK expression levels in patients with portal hypertension. Experimental and Therapeutic Medicine, 2016 12(3), 1618-1624.
Shi M, Wei J, Dong J, Meng W, Ma J, Wang T, Wang N, Wang Y. （通讯作者） Function of interleukin-17 and -35 in the blood of patients with hepatitis B-related liver cirrhosis. Mol Med Rep. 2015 11(1):121-6.
Xu L, Wang T, Meng WY, Wei J, Ma JL, Shi M, Wang YG. （通讯作者） Salinomycin inhibits hepatocellular carcinoma cell invasion and migration through JNK/JunD pathway-mediated MMP9 expression. Oncol Rep. 2015 33(3):1057-63.
Wang YG, Xu L, Wang T, Wei J, Meng WY, Wang N, Shi M. Givinostat inhibition of hepatic stellate cell proliferation and protein acetylation. World J Gastroenterol. 2015 21;21(27):8326-39.
Wang F, Dai W, Wang Y, Shen M, Chen K, Cheng P, Zhang Y, Wang C, Li J, Zheng Y, Lu J, Yang J, Zhu R, Zhang H, Zhou Y, Xu L, Guo C. The synergistic in vitro and in vivo antitumor effect of combination therapy with salinomycin and 5-fluorouracil against hepatocellular carcinoma. PLoS One. 2014 9(5):e97414
Dai W, Wang C, Wang F, Wang Y, Shen M, Chen K, Cheng P, Zhang Y, Yang J, Zhu R, Zhang H, Li J, Zheng Y, Lu J, Zhou Y, Xu L, Guo C. Anti-miR-197 inhibits migration in HCC cells by targeting KAI 1/CD82. Biochem Biophys Res Commun. 2014 446(2):541-8.
Li GM, Wang YG, Pan Q, Wang J, Fan JG, Sun C. RNAi screening with shRNAs against histone methylation-related genes reveals determinants of sorafenib sensitivity in hepatocellular carcinoma cells. Int J Clin Exp Pathol 2014 15;7(3):1085-92.
Wang Y, Dong J, Meng W, Ma J, Wang N, Wei J, Shi M. Effects of phased joint intervention on IL-35 and IL-17 expression levels in patients with portal hypertension. Int J Mol Med. 2014 33(5):1131-9.
Ma J, Shi M, Li G, Wang N, Wei J, Wang T, Ma J, Wang Y. （通讯作者） Regulation of Id1 expression by epigallocatechin-3-gallate and its effect on the proliferation and apoptosis of poorly differentiated AGS gastric cancer cells. Int J Oncol. 2013 43(4):1052-8.
Wang YG, Wang N, Li GM, Fang WL, Wei J, Ma JL, Wang T, Shi M. Mechanisms of trichostatin A inhibiting AGS proliferation and identification of lysine-acetylated proteins. World J Gastroenterol 2013 19(21):3226-40.
Wang YG, Fang WL, Wei J, Wang T, Wang N, Ma JL, Shi M. The involvement of NLRX1 and NLRP3 in the development of nonalcoholic steatohepatitis in mice. J Chin Med Assoc. 2013 76(12):686-92.
Wei J, Shi M, Wu WQ, Xu H, Wang T, Wang N, Ma JL, Wang YG. （通讯作者） IκB kinase-beta inhibitor attenuates hepatic fibrosis in mice. World J Gastroenterol. 2011 17(47):5203-13.
Wang Y, Shi M, Fu H, Xu H, Wei J, Wang T, Wang X. Mammalian target of the rapamycin pathway is involved in non-alcoholic fatty liver disease. Mol Med Rep. 2010 3(6):909-15.
Wang YG, Shi M, Wang T, Shi T, Wei J, Wang N, Chen XM. Signal transduction mechanism of TRB3 in rats with non-alcoholic fatty liver disease. World J Gastroenterol. 2009 21;15(19):2329-35.