导师姓名： 施敏 专业代码： 100201
性别： 男 专业名称： 内科学
培养单位： 附属同仁医院 三级学科/
专业领域： 消化系病
导师类型： 博士生导师 专业学位导师： 兼
联系方式： shimingdyx@163.com
邮编： 200336 邮箱地址： shimingdyx@163.com

研究方向 (点击浏览详细信息)
肝纤维化、脂肪肝基础和临床研究

社会任职
上海市医学会消化病分会肝胆学组委员
中国中西医结合学会肝病专业委员会青年委员
上海市医学会消化病分会生物样本库与转化医学学组委员
上海市医学会肝病分会肝肠学组委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 负载ZM-029的M1-exosomes靶向协同调控巨噬细胞极化治疗肝纤维化的 研究 国家自然科学基金面上项目 2020-01~2023-12 55万元 课题负责人
** 新型HATs抑制剂EQ-530调控VDAC1位点K224乙酰化修饰抗肝纤维化研究 国家自然科学基金面上项目 2016-01~2019-12 68.4万元 课题负责人
** 内镜套扎联合部分脾栓塞术治疗门脉高压症临床研究 上海市科委引导类基金 2014-10~2017-10 10万元 课题负责人
** 表没食子儿茶素没食子酸酯对肝星状细胞增殖及NLRP3炎症小体的影响 上海市卫计委 2014-01~2016-12 9万元 课题负责人
LY201101 IL-35在乙肝肝硬化发病进展中的作用机制研究 上海交通大学六院集团基金 2011-01~2013-12 6万元 课题负责人
** 调节性T细胞动态变化与干扰素治疗慢性乙肝临床疗效相关性的研究 上海市长宁区卫计委基金项目 2008-01~2011-01 3万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Wang YG, Zheng DH, Shi M （通讯作者）, Xu XM. T cell dysfunction in chronic hepatitis B infection and liver cancer: evidence from transcriptome analysis. J Med Genet. 2019 56(1):22-28.
Wang YG, Wang T, Ding M, Xiang SH, Shi M （通讯作者）, Zhai B hsa_circ_** acts as a ceRNA to suppress hepatocellular cancer progression by sponging hsa-miR-1307 Cancer Lett. 2019 2019 Sep 28;460:128-138.
Wang YG, Wang T, Shi M （通讯作者）, Zhai B. Long noncoding RNA EPB41L4A-AS2 inhibits hepatocellular carcinoma development by sponging miR-301a-5p and targeting FOXL1. J Exp Clin Cancer Res. 2019 38(1):153.
Wu Q, Xiang S, Ma J, Hui P, Wang T, Meng W, Shi M （通讯作者）, Wang Y. Long non-coding RNA CASC15 regulates gastric cancer cell proliferation,migration and epithelial mesenchymal transition by targeting CDKN1A and ZEB1. Mol Oncol. 2018 Jun;12(6):799-813.
Xu L, Gong C, Li G, Wei J, Wang T, Meng W, Shi M （通讯作者）, Wang Y. Ebselen suppresses inflammation induced by Helicobacter?pylori lipopolysaccharide via the p38 mitogen-activated protein kinase signaling pathway. Mol Med Rep 2018 17(5):6847-6851.
Shi M （共同第一作者）, Jiang Y, Yang L, Yan S, Wang YG, Lu XJ. Decreased levels of serum exosomal miR-638 predict poor prognosis in hepatocellular carcinoma. J Cell Biochem. 2018 119(6):4711-4716.
Deng Y, Chen C, Yu H, Diao H, Shi C, Wang Y, Li G, Shi M. （通讯作者） Oridonin ameliorates lipopolysaccharide/D-galactosamine-induced acute liver injury in mice via inhibition of apoptosis. Am J Transl Res. 2017 9(9):4271-4279
Shi M, Zhang XY, Yu H, Xiang SH, Xu L, Wei J, Wu Q, Jia R, Wang YG, Lu XJ DDX11-AS1 as potential therapy targets for human hepatocellular carcinoma Oncotarget 2017 8(27):44195-44202.
Shi M, Wei J, Meng WY, Wang N, Wang T, Wang YG. Effects of phased joint intervention on Rho/ROCK expression levels in patients with portal hypertension. Experimental and Therapeutic Medicine, 2016 12(3):1618-1624.
Wang YG, Xu L, Jia RR, Wu Q, Wang T, Wei J, Ma JL, Shi M, Li ZS. DDR2 Induces Gastric Cancer Cell Activities via Activating mTORC2 Signaling and Is Associated with Clinicopathological Characteristics of Gastric Cancer. Dig Dis Sci. 2016 61(8):2272-83.
Shi M, Lu XJ, Zhang J, Diao H, Li G, Xu L, Wang T, Wei J, Meng W, Ma JL, Yu H,Wang YG. Oridonin, a novel lysine acetyltransferases inhibitor, inhibits proliferation and induces apoptosis in gastric cancer cells through p53- and caspase-3-mediated mechanisms. Oncotarget. 2016 7(16):22623-31.
Wang YG, Xu L, Wang T, Wei J, Meng WY, Wang N, Shi M. （通讯作者） Givinostat inhibition of hepatic stellate cell proliferation and protein acetylation World J Gastroenterol. 2015 21(27): 8326–8339.
Xu L, Wang T, Meng WY, Wei J, Ma JL, Shi M （通讯作者）, Wang YG. Salinomycin inhibits hepatocellular carcinoma cell invasion and migration through JNK/JunD pathway-mediated MMP9 expression. Oncol Rep. 2015 33(3):1057-63.
Shi M, Wei J, Dong J, Meng W, Ma J, Wang T, Wang N, Wang Y. Function of interleukin-17 and -35 in the blood of patients with hepatitis B-related liver cirrhosis. Mol Med Rep. 2015 11(1):121-6.
Wang Y, Dong J, Meng W, Ma J, Wang N, Wei J, Shi M. （通讯作者） Effects of phased joint intervention on IL-35 and IL-17 expression levels in patients with portal hypertension. Int J Mol Med. 2014 33(5):1131-9.
Wang YG, Fang WL, Wei J, Wang T, Wang N, Ma JL, Shi M. （通讯作者） The involvement of NLRX1 and NLRP3 in the development of nonalcoholic steatohepatitis in mice. J Chin Med Assoc. 2013 76(12):686-92.
Wang YG, Wang N, Li GM, Fang WL, Wei J, Ma JL, Wang T, Shi M. （通讯作者） Mechanisms of trichostatin A inhibiting AGS proliferation and identification of lysine-acetylated proteins. World J Gastroenterol 2013 19(21):3226-40.
Ma J, Shi M, Li G, Wang N, Wei J, Wang T, Ma J, Wang Y. Regulation of Id1 expression by epigallocatechin?3?gallate and its effect on the proliferation and apoptosis of poorly differentiated AGS gastric cancer cells. Int J Oncol. 2013 43(4):1052-8.
Wang YG, Fang WL, Wei J, Wang T, Wang N, Ma JL, Shi M. （通讯作者） The involvement of NLRX1 and NLRP3 in the development of nonalcoholic steatohepatitis in mice. J Chin Med Assoc. 2013 76(12):686-92.
Wei J, Shi M, Wu WQ, Xu H, Wang T, Wang N, Ma JL, Wang YG. IκB kinase-beta inhibitor attenuates hepatic fibrosis in mice. World J Gastroenterol. World J Gastroenterol. 2011 17(47):5203-13
Wang Y, Shi M, Fu H, Xu H, Wei J, Wang T, Wang X. Mammalian target of the rapamycin pathway is involved in non-alcoholic fatty liver disease. Mol Med Rep. 2010 3(6):909-15.
Wang YG, Shi M, Wang T, Shi T, Wei J, Wang N, Chen XM. Signal transduction mechanism of TRB3 in rats with non-alcoholic fatty liver disease. World J Gastroenterol. 2009 15(19):2329-35.