刘德龙 研究员

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传真：
邮箱：dlliu@sjtu.edu.cn
主页：药学院7号楼314室


个人简历 研究方向 发表论文 科研成果
刘德龙，研究员/博士生导师，上海市手性药物分子工程重点实验室副主任。2007年博士毕业于上海交通大学，2009年在本校化学博士后流动站出站后，进入上海交通大学药学院从事教学与科研工作至今。相关研究成果在本领域包括J. Am. Chem. Soc.和Angew. Chem. Int. Ed.等顶级期刊在内的学术期刊上发表SCI论文50余篇，近20项发明专利获授权。近几年，主持国家自然科学基金面上项目3项、省部级基金2项、以课题副组长身份参与国家重大专项子课题1项、参与其它省部级和横向合作基金多项。

1）手性药物的高效合成方法研究；
2）不对称催化。


1."Synthesis of Chiral γ-Lactones via a RuPHOX-Ru Catalyzed Asymmetric Hydrogenation of Aroylacrylic Acids", Yufei Lu, Jing Li, Yue Zhu, Jiefeng Shen*, Delong Liu*, and Wanbin Zhang, Tetrahedron, 2019, 75, 3643-3649.
2."Selective Asymmetric Hydrogenation of Four-membered exo-α,β-Unsaturated Cyclobutanones Using RuPHOX-Ru as a Catalyst", Jing Li, Yufei Lu, Yue Zhu, Yu Nie, Jiefeng Shen*, Yangang Liu, Delong Liu*, and Wanbin Zhang*, Org. Lett., 2019, 21, 4331-4335.
3."Synthesis of Chiral γ-Lactones via a RuPHOX-Ru Catalyzed Asymmetric Hydrogenation of γ-Keto Acids", Jing Li, Yujie Ma, Yufei Lu, Yangang Liu, Delong Liu*, and Wanbin Zhang*, Adv. Synth. Catal., 2019, 361, 1146-1153.
4."Pd-catalyzed asymmetric allylic substitution cascade using α-(pyrdin-1-yl)-acetamides formed in situ as nucleophiles", Kun Yao, Qianjian Yuan, Xingxin Qu, Yangan Liu, Delong Liu*, and Wanbin Zhang*, Chem. Sci., 2019, 10, 1767-1772.
5."Synthesis of Chiral Chromanols via a RuPHOX-Ru Catalyzed Asymmetric Hydrogenation of Chromones", Yujie Ma, Jing Li, Jianxun Ye, Delong Liu*, and Wanbin Zhang, Chem. Commun., 2018, 54, 13571-13574.
6."Synthesis of (+)-Salvianolic Acid A from Sodium Danshensu", Kai Xu, Hao Liu, Delong Liu, Cheng Sheng, Jiefeng Shen*, and Wanbin Zhang*, Tetrahedron, 2018, 74, 5996-6002.
7.Invited Perspective: "The Synthesis of Trandolapril Key Intermediate—trans-Perhydroindolic Acids and Their Application in Asymmetric Organocatalyzed Cascade Reactions", Delong Liu and Wanbin Zhang*, Chin. J Pharma., 2017, 48(10): 1395-1408.
8."The Synthesis of Chiral α-Aryl α-Hydroxyl Carboxylic Acids via RuPHOX-Ru Catalyzed Asymmetric Hydrogenation", Huan Guo, Jing Li, Delong Liu*, and Wanbin Zhang, Adv. Synth. Catal., 2017, 359, 3665–3673.
9."The Synthesis of Chiral α,β-Unsaturated γ-Amino Esters via Pd-Catalyzed Asymmetric Allylic Amination", Chao Xia, Jiefeng Shen, Delong Liu*, and Wanbin Zhang*, Org. Lett., 2017, 19, 4251?4254.
10."The Construction of Chiral Fused Tricyclic γ-Lactams via a trans-Perhydroindolic Acid-Catalyzed Asymmetric Domino Reaction", Qianjin An, Jiefeng Shen, Delong Liu*, Yangang Liu, and Wanbin Zhang*, Org. Lett., 2017, 19, 2925-2928.
11."Synthesis of Chiral γ-Lactams via in Situ Elimination/Iridium-Catalyzed Asymmetric Hydrogenation of Racemic γ-Hydroxy γ-Lactams", Qianjia Yuan, Delong Liu*, and Wanbin Zhang*, Org. Lett., 2017, 19, 1886-1889.
12.Invited for Artemisinin Special Issue: "The Development on the Research of Industrial Production of Artemisinin", Delong Liu, and Wanbin Zhang*, Chin. Sci. Bull., 2017, 62, 1997-2006.
13."Iridium-Catalyzed Asymmetric Hydrogenation of β,γ-Unsaturated γ-Lactams: Scope and Mechanistic Studies", Qianjia Yuan, Delong Liu*, and Wanbin Zhang*, Org. Lett., 2017, 19, 1144-1147.
14."The Construction of Chiral Fused Azabicycles Using a Pd-Catalyzed Allylic Substitution Cascade and Asymmetric Desymmetrisation Strategy", Qianjin An, Delong Liu*, Jiefeng Shen, Yangang Liu, and Wanbin Zhang*, Org. Lett., 2017, 19, 238-241.
15."1,3-Dithianes as Acyl Anion Equivalents in Pd-Catalyzed Asymmetric Allylic Substitution", Kun Yao, Delong Liu*, Qianjia Yuan, Tsuneo Imamoto, Yangang Liu, and Wanbin Zhang*, Org. Lett., 2016, 18, 6296-6299.
16."Palladium-Catalyzed Chemo- and Enantioselective C-O Bond Cleavage of a-Acyloxy Ketones via Hydrogenolysis", Jianzhong Chen, Zhenfeng Zhang, Delong Liu, and Wanbin Zhang*, Angew. Chem. Int. Ed., 2016, 55, 8444-8447.
17."Asymmetric Hydrogenation of α-Substituted Acrylic Acids Catalyzed by a Ruthenocenyl Phosphino-oxazoline-ruthenium Complex", Jing Li, Jiefeng Shen, Chao Xia, Yanzhao Wang, Delong Liu, and Wanbin Zhang*, Org. Lett., 2016, 18, 2122-2125.
18."Hydrogen-Bond Directed Regioselective Pd-Catalyzed Asymmetric Allylic Alkylation: The Construction of Chiral α-Amino Acids with Vicinal Tertiary and Quaternary Stereocenters", Xuan Wei, Delong Liu（并列第一）, Qianjin An, and Wanbin Zhang*, Org. Lett., 2015, 17, 5768-5771.
19."The Construction of 3-Methyl-4-aryl Piperidines via a trans-Perhydroindolic Acid Catalyzed Asymmetric aza-Diels–Alder Reaction", Qianjin An, Jiefeng Shen, Nicholas Butt, Delong Liu*, Yangang Liu, and Wanbin Zhang*, Adv. Synth. Catal., 2015, 357, 3627-3638.
20."Asymmetric Hydrogenation of β-Secondary Amino Ketones Catalyzed by a Ruthenocenyl Phosphino-oxazoline-Ruthenium Complex (RuPHOX-Ru): the Synthesis of γ-Secondary Amino Alcohols", Jianxia Wang, Yanzhao Wang, Delong Liu*, and Wanbin Zhang*, Adv. Synth. Catal., 2015, 357, 3262-3272.
21."Asymmetric Michael Addition of Diphenylphosphine to β,γ-Unsaturated α-Keto Esters Catalyzed by a P-Stereogenic Pincer-Pd Complex", Yang Xu, Zehua Yang, Boqiang Ding, Delong Liu*, Yangang Liu, Masashi Sugiya, Tsuneo Imamoto, and Wanbin Zhang*, Tetrahedron, 2015, 71, 6832-6839.
22."Iridium-Catalyzed Allyl-Allyl Cross-Coupling of Allylic Carbonates with (E)-1,3-Diarylpropenes", Qianjia Yuan, Kun Yao, Delong Liu, and Wanbin Zhang*, Chem. Commun., 2015, 51, 11834-11846.
23."P-Stereogenic Pincer Iridium Complexes: Synthesis, Structural Characterization and Application in Asymmetric Hydrogenation", Zehua Yang, Xuan Wei, Delong Liu*, Yangang Liu, Masashi Sugiya, Tsuneo Imamoto*, and Wanbin Zhang*, J. Organomet. Chem., 2015, 791, 41-45.
24."Synthesis and Structural Characterization of Nickel Complexes Possessing P-Stereogenic Pincer Scaffolds and Their Application in Asymmetric aza-Michael Reactions", Zehua Yang, Delong Liu*, Yangang Liu, Masashi Sugiya, Tsuneo Imamoto*, and Wanbin Zhang*, Organometallics, 2015, 34, 1228-1237.
25."P-Stereogenic PNP Pincer-Pd Catalyzed Intramolecular Hydroamination of Amino-1,3-dienes", Zehua Yang, Chao Xia, Delong Liu, Yangang Liu, Masashi Sugiya, Tsuneo Imamoto*, and Wanbin Zhang*, Org. Biomol. Chem., 2015, 13, 2694-2702.
26."Pd-Catalyzed Asymmetric Allylic Amination Using Easily Accessible Metallocenyl P,N-Ligands", Hongwei Wu, Fang Xie, Yanlan Wang, Xiaohu Zhao, Delong Liu*, and Wanbin Zhang*, Org. Biomol. Chem., 2015, 13, 4248-4254.
27."Temperature-Controlled Switchable Preparation of Ferrocene Bis(oxazoline-phosphine) Ligands with Different Planar Chiralities and Their Coordination Behaviors", Hongwei Wu, Qianjin An, Delong Liu*, and Wanbin Zhang*, Tetrahedron, 2015, 71, 5112-5118.
28."Asymmetric Tandem Reactions of N-Sulfonylimines and α,β-Unsaturated Aldehydes: An Alternative Reaction Pathway to That of Using Saturated Aldehydes", Qianjin An, Jing Li, Jiefeng Shen, Nicholas Butt, Delong Liu*, Yangang Liu, and Wanbin Zhang*, Chem. Commun., 2015, 51, 885-888.
29."Asymmetric Domino Reaction of Cyclic N-Sulfonylimines and Simple Aldehydes with trans-Perhydroindolic Acid as an Organocatalyst", Qianjin An, Jiefeng Shen, Nicholas Butt, Delong Liu*, Yangang Liu, and Wanbin Zhang*, Org. Lett., 2014, 16, 4496-4499.
30.Cover Paper: "Synthesis of Chiral γ-Amino Alcohols via a RuPHOX-Ru Catalyzed Asymmetric Hydrogenation of β-Imide Ketones", Yanzhao Wang, Jianxia Wang, Delong Liu*, and Wanbin Zhang*, Chin. J. Org. Chem., 2014, 34, 1766-1772.
31."Palladium-Catalyzed Allylic Alkylation of Simple Ketones with Allylic Alcohols and Its Mechanistic Study", Xiaohong Huo, Guoqiang Yang, Delong Liu, Yangang Liu, Ilya D. Gridnev*, and Wanbin Zhang*, Angew. Chem. Int. Ed., 2014, 53, 6776-6780.
32."Hydrogen-Bond-Activated Palladium-Catalyzed Allylic Alkylation via Allylic Alkyl Ethers: Challenging Leaving Groups", Xiaohong Huo, Mao Quan, Guoqiang Yang, Xiaohu Zhao, Delong Liu*, Yangang Liu, and Wanbin Zhang*, Org. Lett., 2014, 16, 1570-1573.
33.Invited Account: "The Design and Synthesis of Planar Chiral Ligands and Their Application to Asymmetric Catalysis", Nicholas A. Butt, Delong Liu, and Wanbin Zhang*, Synlett, 2014, 25, 615-630.


1、基于二茂钌骨架的面手性配体/催化剂的设计合成及应用

2、抗心血管病药物群多普利合成工艺创新及其关键中间体作为有机小分子催化剂的应用

3、借助氢键作用的Pd-催化烯丙基“惰性”C-X键断裂反应

4、手性Pincer催化剂的设计、合成及应用