王欣 长聘教轨副教授

邮箱：xinwang2020@sjtu.edu.cn



个人简历 研究方向 发表论文 科研成果
2006-2010 武汉大学化学与分子科学学院 化学基地班 学士
2010-2015 北京大学化学与分子工程学院 分析化学 博士
2014.04-2014.07 美国加州大学伯克利分校 访问博士生
2015-2018 美国麻省理工学院（MIT） 生物药物分析 Postdoctoral Associate
2018-2019 美国麻省理工学院（MIT） 生物药物分析 Senior Postdoctoral Associate
2020 上海交通大学药学院 药物分析 长聘教轨副教授，博士生导师
获2020年上海海外高层次人才引进计划支持


任新型分离介质与生物药物分析课题组组长。研究方向为基于色谱-质谱的药物分离与检测方面的研究。擅长新型整体材料、纳米材料的制备及样品前处理方法的开发；精通色谱、质谱相关领域的研究，特别是痕量药物残留的快速高灵敏度检测，生物药物分析，代谢组学及蛋白质组学的研究。
1.针对药物分子结构设计样品前处理新方法用于药物定性定量检测
2.基于液相色谱-质谱（LC-MS）的代谢组学和蛋白质组学研究
3.新型质谱离子源的开发及其在药物分析中的应用
4.纳流/芯片色谱用于药物分析，手性药物分离


[1] Xin Wang*, Murat Cirit, John S. Wishnok, Linda G. Griffith, and Steven R. Tannenbaum*; Analysis of an Integrated Human Multi-organ Microphysiological System for Combined Tolcapone Metabolism and Brain Metabolomics; Analytical Chemistry, 2019, 91, 8667-8675.
[2] Xin Wang*, Carlos T. Garcia, Guanyu Gong, John S. Wishnok, and Steven R. Tannenbaum*; Automated Online Solid Phase Derivatization for Sensitive Quantification of Endogenous S-Nitrosoglutathione and Rapid Capture of Other Low-Molecular-Mass S-Nitrosothiols; Analytical Chemistry, 2018, 90, 1967-1975.
[3] Xin Wang, Xianjiang Li, Ze Li, Yiding Zhang, Yu Bai and Huwei Liu*; Online coupling of in-tube solid phase microextraction with direct analysis in real time mass spectrometry for rapid determination of triazine herbicides by using polymer monolith incorporated with single-wall carbon nanotubes; Analytical Chemistry, 2014, 86, 4739-4747. (Highly cited paper, cited by: 180 google scholar)
[4] Xin Wang, Xianjiang Li, Yu Bai and Huwei Liu*; Just dip it: Online coupling of “Dip-it” polymer monolith microextraction with plasma assisted laser desorption ionization mass spectrometry; Chemical Communications, 2015, 51, 4615-4618.
[5] Xin Wang, Qiao Ma, Min Li, Cuilan Chang, Yu Bai and Huwei Liu*; Automated and sensitive analysis of 28-epihomobrassinolide in Arabidopsis thaliana by on-line polymer monolith microextraction coupled to liquid chromatography-mass spectrometry; Journal of Chromatography A, 2013,1317, 121-128.
[6] Xin Wang, Alexandros Lamprou, Frantisek Svec,* and Huwei Liu*; Polymer-based Monolithic Column with Incorporated Chiral Metal-Organic Framework for Enantioseparation of Methyl Phenyl Sulfoxide Using Nano-Liquid Chromatography; Journal of Separation Science, 2016, 39, 4544-4548.
[7] Cuilan Chang, Xin Wang, Yu Bai, Huwei Liu*; Applications of nanomaterials in enantioseparation and related techniques; Trends in Analytical Chemistry, 2012, 39, 195-206.
[8] Feifeng Huo, Xin Wang, Yehua Han, Yu Bai, Wei Zhang, Hancheng Yuan, Huwei Liu*; A new derivatization approach for the rapid and sensitive analysis of brassinosteroids by using ultra high performance liquid chromatography-electrospray ionization triple quadrupole mass spectrometry; Talanta, 2012, 99, 420-425.
[9] Xianjiang Li, Xin Wang, Wen Ma, Wanpeng Ai, Li Ding and Huwei Liu*; Fast analysis of glycosides based on HKUST-1-coated monolith solid-phase microextraction and direct analysis in real-time mass spectrometry; Journal of Separation Science, 2017, 40, 1589-1596.
[10] Qiongwei Yu, Xin Wang, Qiao Ma, Bifeng Yuan, Haibo He and Yuqi Feng*; Automated analysis of non-steroidal anti-in?ammatory drugs in human plasma and water samples by in-tube solid-phase microextraction coupled to liquid chromatography-mass spectrometry based on a poly(4-vinylpyridine-co-ethylene dimethacrylate) monolith; Analytical Methods, 2011, 4, 1538-1545.
[11] Xianjiang Li, Xin Wang, Linnan Li, Yu Bai and Huwei Liu*; Direct Analysis in Real Time Mass Spectrometry: a Powerful Tool for Fast Analysis; Mass Spectrometry Letters, 2015, 6, 1-6.
[12] Xianjiang Li, Ze Li, Xin Wang, Honggang Nie, Yiding Zhang, Yu Bai and Huwei Liu*; Monolith dip-it: a bifunctional device for improving the sensitivity of direct analysis in real time mass spectrometry; Analyst, 2016, 141, 4947-4952.
[13] Xianjiang Li, Cuilan Chang, Xin Wang, Yu Bai and Huwei Liu*; Application of homochiral metal-organic frameworks in enantioselective adsorption and chromatography separation; Electrophoresis, 2014, 35, 2733-2743.
[14] Xianjiang Li, Jiawei Xing, Cuilan Chang, Xin Wang, Yu Bai, Xiuping Yan and Huwei Liu*; Solid-phase extraction with the metal–organic framework MIL-101(Cr) combined with direct analysis in real time mass spectrometry for the fast analysis of triazine herbicides; Journal of Separation Science, 2014, 37, 1489-1495.
[15] Cuilan Chang, Xiaoyue Qi, Jiangwei Zhang, Yaming Qiu, Xianjiang Li, Xin Wang, Yu Bai, Jun-Liang Sun and Huwei Liu*; Facile synthesis of magnetic homochiral metal-organic frameworks for “enantioselective fishing”; Chemical Communications, 2015, 51, 3566-3569.
[16] Haitham Amal, Boaz Barak, Vadiraja Bhat, Guanyu Gong, Brian A. Joughin, Xin Wang, John S. Wishnok, Guoping Feng, Steven R. Tannenbaum*; Shank3 mutation in a mouse model of autism leads to changes in the S-nitroso-proteome and affects key proteins involved in vesicle release and synaptic function; Molecular Psychiatry, 2018, 1, 1-14. (Nature series)
[17] Haitham Amal*, Guanyu Gong, Hongmei Yang, Brian A. Joughin, Xin Wang, Charles G. Knutson, Maryam Kartawy, Igor Khaliulin, John S. Wishnok, Steven R. Tannenbaum*; Low doses of arsenic in a mouse model of human exposure and in neuronal culture lead to S-Nitrosylation of synaptic proteins and apoptosis via nitric oxide; International Journal of Molecular Sciences, 2020, 21, 3948-3967.


科研成果：
王欣博士，2010 年本科毕业于武汉大学。2015 年于北京大学获博士学位，期间去美国劳伦斯伯克利国家实验室交流。博士毕业后在美国麻省理工学院（MIT）从事博士后研究；于2018 年提升为Senior postdoc。2020年通过绿色通道人才引进加入上海交通大学，任药学院长聘教轨副教授，博士生导师。王欣首次开发了管内固相微萃取（in-tube SPME）和实时直接分析质谱（DART-MS）在线联用平台并用于药物残留分析，这部分工作发表在分析领域最权威的一区Top 期刊Analytical Chemistry 上，单篇文章被引180余次，并参与2015 年中国分析测试协会科学技术奖一等奖。此外，作为质谱分析负责人，完成由麻省理工学院承担的美国国防高级研究计划局大型项目“human-on-a-chip”（570万美元），因此提升为Senior postdoc。该项目获First Place Prize of MIT Center for Environmental Health Sciences Session，文章同样发表在Analytical Chemistry 上。截止目前，在Analytical Chemistry, Chemical Communications，Molecular Psychiatry等国际知名期刊上发表17篇SCI 论文及9 篇会议论文，近五年被引600余次，一作文章被引250余次。此外，在国内外重要学术会议作报告10余次，包括国际会议“2014 HPLC大会”口头报告及第十五届BCRIA优秀墙报奖。并担任国内外权威杂志评审人，e.g. Journal of Separation Science, Chinese Journal of Chromatography, RSC Advances 等。
学术成果简介：
1. 美国国防高级研究计划局（DARPA）“human-on-a-chip” 项目
首次实现 “human-on-a-chip”系统中的代谢组学研究，报道了药物Tolcapone的三个新代谢产物，完成其代谢途径分析。
2. 全自动在线检测内源性S-亚硝基硫醇类化合物（RSNO）- NIH (US) Grants
成功搭建了全自动的固相衍生化-液相色谱-质谱（SPD-LC-MS）在线联用平台，开发了目前最灵敏的检测RSNO的方法，完成了生物体内内源性RSNO的实时检测。
3. 手性分离新介质的合成和应用（UC Berkeley Contract）
首次将手性MOFs掺杂在聚合物整体材料中合成新型手性分离介质，作为纳流液相色谱（Nano-LC）的色谱柱实现手性药物分离。
4. 常压敞开式质谱新技术及其在药物分析中的应用
制备掺杂有碳纳米材料的聚合物整体材料；开发SPME和DART-MS及 PALDI-MS在线联用平台并用于实际样品中三嗪类农药的快速高灵敏度分析。
课题组招收博士和硕士研究生，热忱欢迎准备攻读硕士、博士学位的同学加入！诚聘博士后研究人员！