张志君
博士，上海交通大学副研究员、硕士生导师。2008年获中科院上海分院神经科学研究所博士学位，2009-2012年期间分别在在美国加州大学旧金山分校和美国马萨诸塞大学医学院接受博士后训练。主要从事星形胶质细胞在脑血管疾病中作用的研究。迄今为止，先后获得国自然、上海市科委、教育部、上海交大等多项基金支持，并在国外重要学术期刊Nature cell biology、Molecular cell、Science、Neuron、PNAS发表多篇重要学术论文，已被引用2000多次。

教育背景
博士 2003.9-2008.1 突触发育和可塑性研究组，中国科学院神经科学研究所
硕士1999.9-2002.7 解剖学系，中南大学湘雅医学院
学士 1993.9-1998.7 临床医学系，新乡医学院
工作经历
2016/1 - 至今， 上海交通大学生物医学工程学院，副研究员
2008/9 - 2015/12， 上海交通大学生物医学工程学院，助理研究员
2002/7 - 2003/9， 中科院神经科学研究所，突触发育与可塑性实验室， 研究助理
研究方向
主要研究领域是胶质细胞在脑血管疾病中的作用以及神经元、胶质细胞、和血管之间的相互作用机制。
科研项目
1．国家自然科学基金面上基金项目主持55万;起止时间1/1/2020–12/31/2023
2．国家自然科学基金面上基金项目主持54万;起止时间1/1/2018–12/31/2021
3．上海市科技创新面上基金 项目主持54万;起止时间7/1/2018– 6/30/2021
4．国家自然科学基金青年基金项目主持20万;起止时间1/1/2008– 12/31/2011
5．上海交通大学医工交叉基金项目主持8万;起止时间2010 – 2012

代表性论文专著
1.Wang J, Lin X, Mu Z, Shen F, Zhang L, Xie Q, Tang Y, Wang Y, Zhang Z*andYangGY*. Rapamycin IncreasesCollateral Circulation in Rodent Brain after Focal Ischemia as detected byMultiple Modality Dynamic Imaging. Theranostics. 2019; 9(17): 4923–4934. doi:10.7150/thno.32676.(*co-corresponding author)
2.Song Y,Li Z, He T, Qu M, Jiang L, Li W, Shi X, Pan J, ZhangL,Wang Y, Zhang Z*, Tang Y, andYang GY. M2microglia-derived exosomes protect the mouse brain from ischemia-reperfusioninjury via exosomal miR-124.Theranostics. 2019; 9(10): 2910–2923.doi:10.7150/thno.30879.(*co-corresponding author)
3.Li Z, Gu Y, Wen R, Shen F, Tian HL, Yang GY, Zhang Z. Lysosomeexocytosis is involved in astrocyte ATP release after oxidative stress inducedby H2O2. Neurosci Lett. 2019 Jul 13;705:251-258. doi:10.1016/j.neulet.2019.03.046.
4.Zhou PT, Wang LP, Qu MJ, Shen H, Zheng HR, Deng LD, Ma YY, Wang YY, WangYT, Tang YH, Tian HL, Zhang ZJ*, Yang GY. Dl-3-N-butylphthalide promotesangiogenesis and upregulates sonic hedgehog expression after cerebral ischemiain rats. CNS Neurosci Ther. 2019 Jun;25(6):748-758. doi: 10.1111/cns.13104. (*co-corresponding author)
5.Wang L, Zhou P, Mu Z, Lin X, Jiang L, Cheng Z, Luo L, Xu Z, Geng J, Wang Y, Zhang Z*, Yang GY. Dynamic Detection of Thrombolysis in Embolic StrokeRats by Synchrotron Radiation Angiography. Transl Stroke Res. 2019 Jan 24. doi:10.1007/s12975-019-0687-6.(*co-corresponding author)
6. Cai H, Ma Y, JiangL, Mu Z, Jiang Z, Chen X, Wang Y, Yang GY, Zhang Z. Hypoxia ResponseElement-Regulated MMP-9 Promotes Neurological Recovery via Glial ScarDegradation and Angiogenesis in Delayed Stroke.Mol Ther. 2017;25(6):1448-1459
7. Lu H, Song X, Wang F,Wang G, Wu Y, Wang Q, Wang Y, Yang GY, Zhang Z. Hyperexpressed Netrin-1 Promoted Neural Stem Cells Migration in Miceafter Focal Cerebral Ischemia.Front Cell Neurosci.2016;10:223.
8. He X, Lu Y, Lin X,Jiang L, Tang Y, Tang G, Chen X, Zhang Z, Wang Y, Yang GY. Optical inhibition of striatal neurons promotesfocal neurogenesis and neurobehavioral recovery in mice after middle cerebralartery occlusion. J Cereb Blood FlowMetab. 2017 ;37(3):837-847.
9. Biswas MH, Almeida S,Lopez-Gonzalez R, Mao W, Zhang Z, Karydas A, Geschwind MD, Biernat J,Mandelkow EM, Futai K, Miller BL, Gao FB. MMP-9 and MMP-2 Contribute to Neuronal Cell Death in iPSC Models ofFrontotemporal Dementia with MAPT Mutations. Stem Cell Reports. 2016;7(3):316-24.
10. Silva MC, Cheng C,Mair W, Almeida S, Fong H, Biswas MH, Zhang Z, Huang Y, Temple S,Coppola G, Geschwind DH, Karydas A, Miller BL, Kosik KS, Gao FB, Steen JA,Haggarty SJ. Human iPSC-Derived Neuronal Model of Tau-A152TFrontotemporal Dementia Reveals Tau-Mediated Mechanisms of NeuronalVulnerability.Stem Cell Reports. 2016;7(3):325-40.
5. Ma Y, Li Y, Jiang L,Wang L, Jiang Z, Wang Y, Zhang Z*, Yang GY*. Macrophage depletion reduced brain injury following middle cerebralartery occlusion in mice. JNeuroinflammation. 2016;13:38.(*co-corresponding author)
6. Cai H, Mu Z, Jiang Z,Wang Y, Yang GY, Zhang Z. Hypoxia-controlledmatrix metalloproteinase-9 hyperexpression promotes behavioral recovery afterischemia.Neurosci Bull. 2015;31(5):550-60.
7. Cai H, Zhang Z,Yang GY. Preconditioned stem cells: a promising strategy forcell-based ischemic stroke therapy. CurrDrug Targets. 2014;15(8):771-9.
8. Liu Y, Tang G, ZhangZ, Wang Y, Yang GY.Metforminpromotes focal angiogenesis and neurogenesis in mice following middle cerebralartery occlusion.Neurosci Lett. 2014;579:46-51.
9. Tang G, Liu Y, ZhangZ, Lu Y, Wang Y, Huang J, Li Y, Chen X, Gu X, Wang Y, Yang GY.Mesenchymal stem cells maintain blood-brain barrierintegrity by inhibiting aquaporin-4 upregulation after cerebral ischemia.Stem Cells. 2014;32(12):3150-62.
10. Liu Y, Tang G, LiY, Wang Y, Chen X, Gu X, Zhang Z, Wang Y, Yang GY.Metformin attenuates blood-brain barrier disruptionin mice following middle cerebral artery occlusion. J Neuroinflammation. 2014;11:177.
11. Chen C, Lin X, Wang J, Tang G, Mu Z, Chen X, Xu J, Wang Y, Zhang Z*, Yang GY*. Effectof HMGB1 on the paracrine action of EPC promotes post-ischemicneovascularization in mice. Stem Cells. 2014;32(10):2679-89.(*co-corresponding author)
12. Zhang Z, Almeida S, Lu Y, NishimuraAL, Peng L, Sun D, Wu B, Karydas AM, Tartaglia MC, Fong JC, Miller BL, FareseRV Jr, Moore MJ, Shaw CE, Gao FB.
Downregulationof microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations. PLoS One. 2013 ;8(10):e76055.
13. Lu Y*, Zhang Z*,Sun D, Sweeney ST, Gao FB. Syntaxin 13, agenetic modifier of mutant CHMP2B in frontotemporal dementia, is required forautophagosome maturation. Mol Cell. 2013;52(2):264-71. (*co-first author)
14. Almeida S, Zhang Z,Coppola G, Mao W, Futai K, Karydas A, Geschwind MD, Tartaglia MC, Gao F, GianniD, Sena-Esteves M, Geschwind DH, Miller BL, Farese RV Jr, Gao FB. Induced pluripotent stem cell models of progranulin-deficientfrontotemporal dementia uncover specific reversible neuronal defects. CellRep. 2012;2(4):789-98.
15. Chen G,Zhang Z,Wei Z,Cheng Q,Li X,Li W,Duan S,Gu X.Lysosomal Exocytosis in Schwann Cells Contributes to AxonRemyelination. Glia 2012; 60:295–305
16. Yongjie Ma, Zhijun Zhang, Xiaoliang Wang, WeiliangXia, Hongchen Gu. Insights into the mechanism of magnetofection using MNPs-PEI/pDNA/freePEI magnetofectins Int J Pharm. 2011;419(1-2):247-54
17. Tong X，Li X,Zhou B, Shen W, Zhang Z, Xu T, DuanS. Ca2+ signaling evoked by activation of Na+ channels and Na+ /Ca2+ exchangersis required for GABA-induced NG2 cell migration. Journalof Cell Biology 2009;186: 113-128
18. Zhang Z*, Chen G*, Zhou W*, Song A, Xu T, Luo Q, Wang W, Gu XS,Duan S. Regulated ATPrelease from astrocytes through lysosome exocytosis. Nat Cell Biol. 2007,9:945-953
19. Luo C, Jiang J, ZhouQ, Zhu X, Wang W, Zhang Z, Han X, Zhu D. Voluntary exercise-induced neurogenesis in thepostischemic dentate gyrus is associated with spatial memory recovery fromstroke. Journal of Neuroscience Research 2007;85:1637-1646
20. Ge W*., Yang X*., Zhang Z., Wang H., Deng Q., DuanS. Long-Term Potentiation of Neuron-Glia Synapses Mediated byCa2+-Permeable AMPA Receptors. Science,2006;312, 1533-1537
21. Shen W*., Wu B*., Zhang Z., Dou Y., Rao Z., Chen Y., DuanS. Activity-induced rapid synaptic maturation mediated by presynaptic cdc42signaling. Neuron, 2006;50: 401-414
22. Yang Y*., Ge W*.,Chen Y., Zhang Z., Shen w., Wu C.,Poo M., and Duan S. Contribution of astrocytes to hippocampallong-term potentiation through release of D-serine. PNAS, 2003;100: 15194 –15199



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