崔家华(Cui Jiahua) 助理研究员电子邮件：cpucjh@sjtu.edu.cn
办公室电话：
办公地点：上海交通大学生物药学楼7-502

研究方向环境污染物的毒理学研究
环境污染物的化学防护
个人简历崔家华，2014年6月博士毕业于上海交通大学药学院，获医学博士学位。同年入选上海交通大学“优秀博士毕业生海外博士后师资储备项目”，并进入上海交通大学生命科学技术学院生物学博士后流动站进行研究工作。2015年获中国博士后科学基金会“香江****计划”项目资助，并于2016年至2018年在香港理工大学应用生物及化学工程系进行博士后研究工作。2019年入职上海交通大学环境科学与工程学院。主要研究领域为天然萘醌类化合物的全合成及结构改造，环境污染物的毒理学研究及化学防护。主持国家自然科学基金青年基金项目、“香江****计划”项目、中国博士后科学基金面上项目、上海交通大学“优秀博士毕业生海外博士后师资储备项目”等。在J. Med. Chem.,Eur. J. Med. Chem., Mol. Pharmaceutics, Curr. Med. Chem.等期刊发表SCI论文20多篇，其中第一作者、通讯作者论文十余篇。
代表性论著Junqi Cui^#, Xiaobo Zhou^#, Jia Huang, Jiahua Cui* and Jun Chen*. The Selective Antitumor Effect of Shikonin Derived DMAKO-20 on Melanoma through CYP1B1. Curr. Cancer Drug Targets, 2020, DOI : 10.2174/**937.
Gege Sun, Iris L. Wong, Jiahua Cui, Zhen Liu, Bill T. Chan, Larry M. Chow. Investigate the mechanism of actions of flavonoid dimers in reversing doxorubicin resistance in breast cancer stem cells. Cancer Res., 2020, 80 (16 Suppl), Abstract nr 3795.
Jinyun Dong, Guang Huang, Qing Cui, Qingqing Meng, Shaoshun Li* and Jiahua Cui*. Discovery of Heterocycle-Containing α-Naphthoflavone Derivatives as Water-Soluble, Highly Potent and Selective Cyp1b1 Inhibitors. Eur. J. Med. Chem., 2020, 112895,DOI: 10.1016/j.ejmech.2020.112895.
Jiahua Cui*, Shaoshun Li and Jinping Jia*. A regioselective synthesis of 7-methyl juglone and its derivatives. Nat. Prod. Res., 2020, DOI: 10.1080/**.2020.**.
Jiahua Cui* and Jinping Jia*. Natural COX-2 inhibitors as promising anti-inflammatory agents: an update. Curr. Med. Chem., 2020, DOI: 10.2174/39.
Jinyun Dong, Zengtao Wang, Jiahua Cui, Qingqing Meng, Shaoshun Li. Synthesis and structure-activity relationship studies of α-naphthoflavone derivatives as CYP1B1 inhibitors, Eur. J. Med. Chem., 2020, 187, 111938. DOI: 10.1016/j.ejmech.2019.111938.
Jiahua Cui^#, Xu Zhang^#, Guang Huang^#, Qijiang Zhang, Jinyun Dong, Gege Sun, Qingqing Meng* and Shaoshun Li*. DMAKO-20 as a new multi-target anticancer prodrug activated by the tumor specific CYP1B1 enzyme. Mol. Pharmaceutics, 2019, 16 (1), 409-421.
Jiahua Cui*, Xiaoyang Liu and Larry M. C. Chow. Flavonoids as P-gp inhibitors: a systematic review of SARs. Curr. Med. Chem., 2019, 26 (25), 4799-4831.
Jinyun Dong, Zengtao Wang, Qingqing Meng, Qijing Zhang, Guang Huang, Jiahua Cui*, Shaoshun Li*. Development of 2-arylbenzo[h]quinolone analogs as selective CYP1B1 inhibitors. RSC Advances, 2018, 8(27), 15009-15020. (*: Correspondent)
Jinyun Dong, Qijing Zhang, Qingqing Meng, Zengtao Wang, Shaoshun Li*, Jiahua Cui*. Chemistry and Pharmacology of Thioflavones. Mini-Rev. Med. Chem., 2018, 18(20), 1714 – 1732.Qijing Zhang, Jinyun Dong, Qing Cui, Shaoshun Li*; Jiahua Cui*. Synthesis of 4,8-dimethoxy-1-naphthol via an acetyl migration. Synth. Commun., 2017, 47(6), 536-540.
Jiahua Cui^#, Qingqing Meng^#, Xu Zhang, Qing Cui, Wen Zhou and Shaoshun Li*. Design and synthesis of new α-naphthoflavones as cytochrome P450 (CYP) 1B1 inhibitors to overcome docetaxel-resistance associated with CYP1B1 overexpression. J. Med. Chem., 2015, 58(8), 3534-3547.
Jiahua Cui, Qing Cui, Qijing Zhang, Shaoshun Li. An efficient multigram synthesis of juglone methyl ether. J. Chem. Res., 2015, 39(9), 553-554.
Jiahua Cui and Shaoshun Li. Inhibitors and prodrugs targeting CYP1: a novel approach in cancer prevention and therapy. Curr. Med. Chem., 2014, 21(5), 519-552.
Jiahua Cui and Shaoshun Li. An efficient synthesis of 5,6-dimethoxy 1- and 2-naphthols via Teuber reaction. J. Chin. Chem. Soc., 2013, 60(9), 1163-1168.
Jiahua Cui and Shaoshun Li. Structure, chemistry and pharmacology of naphthoflavones. Mini-Rev. Med. Chem., 2013, 13(9), 1357-1368.
Jiahua Cui, Dagula Hu, Xu Zhang, Zheng Jing, Jing Ding, Rubing Wang and Shaoshun Li. Design and synthesis of new 7,8-dimethoxy-α-naphthoflavones as CYP1A1 inhibitors. Chin. Chem. Lett., 2013, 24(3), 215-218.
Jiahua Cui and Shaoshun Li. A convenient and efficient synthesis of 2,6-dihydroxynaphthalene. J. Chem. Res., 2012, 36(11), 675-677.
Jiahua Cui, Wen Zhou and Shaoshun Li. A convenient and efficient synthesis of 2-acetyl-5,8-dimethoxy-1,4-naphthoquinone. J. Chem. Res., 2012, 36(5), 264-265.
Yao-yao Yang^#, Hui-qiong He^#, Jia-hua Cui^#, Yun-juan Nie, Ya-xian Wu, Rui Wang, Gang Wang, Jun-Nian Zheng, Richard D. Ye, Qiong Wu, Shao-shun Li, Feng Qian. Shikonin derivative DMAKO-05 inhibits Akt signal activation and melanoma proliferation. Chem. Biol. Drug Des., 2016, 87(6), 895-904. (#: Co-first author)
Xuezhen Zhu, Iris Wong, Kin-Fai Chan, Jiahua Cui, Man Chun Law, Tsz Cheung Chong, Xuesen Hu, Larry M. C. Chow* and Tak Hang Chan*. Triazole bridged flavonoid dimers as potent, nontoxic, and highly selective breast cancer resistance protein (BCRP/ABCG2) inhibitors. J. Med. Chem., 2019, 62(18), 8578-8608.
Jinyun Dong, Guang Huang, Qijing Zhang, Zengtao Wang, Jiahua Cui, Yan Wu, Qingqing Meng*, Shaoshun Li*. Development of benzochalcone derivatives as selective CYP1B1 inhibitors and anticancer agents. MedChemComm, 2019, 10(9), 1606-1614.
Xu Zhang, Jiahua Cui, Qingqing Meng, Shaoshun Li, Wen Zhou and Sui Xiao. Advance in Anti-tumor Mechanisms of Shikonin, Alkannin and Their Derivatives. Mini-Rev. Med. Chem., 2018, 18(2), 164-172.
Qingqing Meng, Zengtao Wang, Jiahua Cui, Qing Cui, Jinyun Dong, Qijing Zhang, Shaoshun Li. Design, Synthesis, and Biological Evaluation of Cytochrome P450 1B1 Targeted Molecular Imaging Probes for Colorectal Tumor Detection. J. Med. Chem., 2018, 61(23), 10901–10909.
Qijing Zhang, Jinyun Dong, Jiahua Cui, Guang Huang, Qingqing Meng, Shaoshun Li. Cytotoxicity of Synthesized 1,4-Naphthoquinone Oxime Derivatives on Selected Human Cancer Cell Lines. Chem. Pharm. Bull., 2018, 66(6), 612-619.
Xu Zhang, Jiahua Cui, Wen Zhou, Shaoshun Li. Design, synthesis and anticancer activity of shikonin and alkannin derivatives with different substituents on the naphthazarin scaffold. Chem. Res. Chinese U., 2015, 31(3), 394-400.
Rubing Wang, Wen Zhou, Qingqing Meng, Xu Zhang, Jing Ding, Yan Xu, Hualong Song, Kai Yang, Jiahua Cui, Shaoshun Li. Design, synthesis and biological evaluation of shikonin and alkannin derivatives as potential anticancer agents via a prodrug approach. ChemMedChem, 2014, 9(12), 2798-2808.
Rubing Wang, Hui Guo, Jiahua Cui and Shaoshun Li. A novel and efficient total synthesis of shikonin. Tetrahedron. Lett., 2012, 53, 3977-3980.
黄莉，宋化龙，崔家华*，李绍顺*。水溶性紫草素磺酸钠衍生物的设计合成及抗肿瘤活性研究, 中国药物化学杂志, 2016, 26(5), 361-368。

出版专著/合著：
Jiahua Cui*, Shaoshun Li and Jinping Jia*. 2020. "Naphthoquinone Oximes: Structure, Chemistry and Biological Activities." In Oximes: Structure, Properties and Applications, edited by Gillian Cannon. NY: Nova Science Publishers.
Jiahua Cui and Shaoshun Li. 2019. " Naphthoquinone-Contained Anticancer Terrestrial Plants." In Plants that Fight Cancer, 2nd Edition, edited by Spyridon E. Kintzios and Maria G.Barberaki. Boca Raton: CRC Press.

研究成果上海交通大学“交大之星”计划 医工交叉研究基金项目，YG2019QNB13，紫草素肟衍生物抗恶性黑色素瘤的机理研究，2020/01-2022/12，在研，主持。
国家自然科学基金青年基金项目，**，α-萘黄酮类CYP1B1酶抑制剂的设计、合成及其逆转紫杉烷类抗肿瘤药物耐药的机制研究，2017/01-2019/12，已结题，主持。
中国博士后科学基金会“香江****计划”项目，XJ**，肿瘤干细胞的抗药性机理及小分子逆转耐药研究，已结题，主持。
中国博士后基金面上项目，2014M561479，以CYP1B1酶为靶点的近红外荧光探针的设计合成及生物学基础研究，2015/01-2018/12，已结题、主持。
国家自然科学基金面上项目，**，由肿瘤细胞特异性表达的CYP1酶活化的抗肿瘤前药萘醌肟衍生物的设计合成，活性评价及代谢研究，2017/01-2020/12，在研，参加。
国家自然科学基金面上项目，**，以紫草素及二甲基紫草素肟衍生物为小分子探针，探索其抗肿瘤作用的新靶点和新机制，2014/01-2017/12，已结题，参加
上海市科委生物医药领域科技支撑项目，**，逆转多西紫杉醇耐药的新药候选物NF-60的成药性研究，2015/09-2018/06，已结题，参加。
贾金平，崔家华。一种抗新型冠状病毒的萘醌类化合物及其医药用途。中国发明专利授权专利号：ZL 5.0。
李绍顺, 崔家华。外消旋体紫草素肟氨基酸酯衍生物及其制备方法和用途。中国发明专利授权专利号：ZL 2.5。
李绍顺, 崔家华, 董金云，孟青青。水溶性氮杂α-萘黄酮类化合物及其制备方法和医药用途。中国发明专利授权专利号：ZL 0.3。
李绍顺, 崔家华, 孟青青。水溶性α-萘黄酮醇衍生物及其制备方法、用途。国际发明专利申请号：PCT CN2014/091234。
李绍顺, 宋化龙, 崔家华。外消旋体紫草素萘茜母核羟基甲基化磺酸钠衍生物。中国发明专利授权专利号：ZL 1.9。
李绍顺, 崔家华, 张旭。α-萘黄酮衍生物及其制备方法、用途。中国发明专利授权专利号：ZL 9。
李绍顺，崔庆，孟青青，崔家华。水溶性α-萘黄酮醇衍生物及其制备方法、用途。中国发明专利授权专利号：ZL 3。
荣获奖项2016年03月 中国博士后管委会办公室-香港****协会 “香江****”奖
2014年06月 上海交通大学“优秀博士毕业生海外博士后师资储备项目”
2013年12月 博士研究生国家奖学金
2012年10月 第十八届上海高校学生创造发明“科技创业杯”二等奖

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