外文题目: Real-time intravascular photoacoustic-ultrasound imaging of lipid-laden plaque at speed of video-rate level
作者: Hui, Jie; Cao, Yingchun; Zhang, Yi; Kole, Ayeeshik; Wang, Pu; Yu, Guangli; Eakins, Gregory; Sturek, Michael; Chen, Weibiao; Cheng, Ji-Xin
刊名: Proc.SPIE
来源图书: PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2017
年: 2017 卷: 10064
会议名称: Conference on Photons Plus Ultrasound - Imaging and Sensing
英文关键词:
photoacoustic; intravascular imaging; real-time; overtone absorption; lipid; atherosclerosis; video-rate imaging
ATHEROSCLEROSIS; CORONARY; CATHETER
英文摘要:
Intravascular photoacoustic-ultrasound (IVPA-US) imaging is an emerging hybrid modality for the detection of lipid-laden plaques by providing simultaneous morphological and lipid-specific chemical information of an artery wall. The clinical utility of IVPA-US technology requires real-time imaging and display at speed of video-rate level. Here, we demonstrate a compact and portable IVPA-US system capable of imaging at up to 25 frames per second in real-time display mode. This unprecedented imaging speed was achieved by concurrent innovations in excitation laser source, rotary joint assembly, 1 mm IVPA-US catheter, differentiated A-line strategy, and real-time image processing and display algorithms. By imaging pulsatile motion at different imaging speeds, 16 frames per second was deemed to be adequate to suppress motion artifacts from cardiac pulsation for in vivo applications. Our lateral resolution results further verified the number of A-lines used for a cross-sectional IVPA image reconstruction. The translational capability of this system for the detection of lipid-laden plaques was validated by ex vivo imaging of an atherosclerotic human coronary artery at 16 frames per second, which showed strong correlation to gold-standard histopathology.


文献类型: 会议论文
正文语种: English
收录类别: ISTP
DOI: 10.1117/12.2251511


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