摘要/Abstract
传统基于锁钥模型的“一对一”响应的化学检测方式，随着时代发展已经越来越不能满足人们对复杂体系的检测需求.正交检测阵列通过对不同被检测物的差异化信息进行分析，可以获得尽可能多的响应信息，从而实现对多底物的识别检测.多底物检测的关键是要获得尽量多的差异化传感信息.由于存在对探针需求种类量多、合成制备过程复杂、探针有效性筛选效率低等缺点，传统“多对多”方式的多元分析方法，在实际应用过程中显现出巨大的局限性.受人类感官系统的启发，发展“单对多”的高效多底物检测分析手段，将会是未来能真正走向应用的重要发展方向.从化学信息挖掘、物理信号放大与集成器件设计三个方面，针对如何提高多底物复杂分析的能力，总结简述了近期高效多底物检测与多元分析方法的研究进展.
关键词: 多底物检测, 高灵敏检测, 光子晶体, 阵列芯片, 动态分析
The traditional "lock and key" sensor models pursue the "one to one" sensing response for the specific testing and the low limitation of detection, which neglect the practical sample detecting application with multi-analytes and complex contains. Utilizing multi-sensor compounds, the sensor array chip offers multiplex differential sensing response signal to process the multi-analytes discrimination. The critical requirement for successful multi-analyte recognition is to acquire abundant sensing information. However, the "multi to multi" sensor chip needs large numbers of serial probe compounds, which involve com-plicated chemical synthesis and valid compound screening. Inspired by the human sense organ, scientists developed various "cross-reactive" sensor arrays. Here, The recent research progress of multi-analysis and "one to multi" high-efficient detection were introduced. From chemical information excavation, physical signal enhancement, devices integration design, we summarize and forecast the multi-analysis advancement and intelligent sensors.
Key words: multi-analysis, high-performance detection, photonic crystal, sensor array chip, dynamic analysis
PDF全文下载地址:
点我下载PDF
