摘要/Abstract

报道了氧联1,7-烯炔与乙腈、丙酮通过α-C嵌入方式合成2-取代环戊烯并[c]色烯衍生物. 本反应具有底物范围广、基团兼容性好及产率良好等优点. 研究表明这是一个自由基反应过程, 也是构建含氧杂环一个有效的方法. 产物2-氰基-3a,8-二甲基-1-对氟苯基-2,3,3a,4-四氢环戊烯并[c]色烯(3am)的晶体衍射分析进一步确定了产物的结构.
关键词: 自由基反应, 氧联1,7-烯炔, 色烯, 溴化亚铜
The efficient synthesis of 2-substituted cyclopenta[c]chromene derivatives was realized by α-C insertion of acetonitrile (acetone) with oxygen-linked 1,7-enynes catalyzed by cuprous bromide. The advantages of this reaction were wide range of substrates, high compatiblity of functional groups and good yield. The results showed that this was a radical reaction process, and it was also an effective way to construct oxygen-containing heterocycles. The X-ray diffraction analysis of 1-(4-fluorophenyl)-3a,8-dimethyl-2,3,3a,4-tetrahydrocyclopenta[c]chromene-2-carbonitrile (3am) further confirmed the structure of the product.
Key words: radical reaction, oxygen-linked 1,7-enyne, chromene, CuBr


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