摘要/Abstract

石斛碱(Dendrobine)是一类从传统中药金钗石斛中分离得到的具有Picrotoxane倍半萜碳骨架的生物碱类天然产物. 由于该化合物具有多环稠合和七个连续立体中心的结构特点, 以及镇痛和退热等药理活性, 引起了众多有机合成化学家和药物化学家的关注. 五十年来, 天然产物Dendrobine的药理活性研究和化学合成不断涌现, 主要总结了天然产物Dendrobine的生源途径和合成研究进展.
关键词: 天然产物, 倍半萜生物碱, 石斛碱, 全合成, 木防己毒烷
Dendrobine is an important sesquiterpenoid alkaloid bearing the picrotoxane carbon skeleton isolated from the traditional Chinese medicine “Chin-Shih-Hu”. Because of structural characteristics of fused polycyclic and seven contiguous stereocenters, and exhibiting analgesic, antipyretic activities, dendrobine has attracted a great deal of attentions from both synthetic organic chemists and medicinal chemists. Over the past 50 years, there has been a number of research reports on the pharmacological activities and chemical synthesis of dendrobine. This review summarizes the biosynthetic hypothesis and synthetic advances on dendrobine.
Key words: natural product, sesquiterpenoid alkaloid, dendrobine, total synthesis, picrotoxane


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