摘要/Abstract

氟原子或含氟基团在材料科学、药物化学等领域的生物活性分子中广泛存在. 三氟乙基酮亚胺同时存在高活性亲电和亲核中心, 是良好的1,3-偶极子. 因其在催化不对称构建含有三氟甲基立体中心的反应中具有极高的研究价值而备受关注. 以三氟乙基酮亚胺的底物和反应类型为主线, 综述了近五年三氟乙基酮亚胺参与的催化不对称反应研究进展, 同时对该领域的未来发展进行了展望.
关键词: 三氟乙基酮亚胺, 不对称催化, 环加成反应, 三氟甲基, 手性胺合成
The fluorine atoms or fluorine-containing groups are widely found in biologically molecules in the fields of materials science, pharmaceutical chemistry, etc. The properties of trifluoroethylketimines provide both electrophilic and nucleophilic centers, and become an excellent 1,3-dipole, which possessed high research value in catalytic asymmetric reactions of construction of trifluoromethyl stereocenters. Based on the substrates and reaction types of trifluoroethylketimine, the research progress of catalytic asymmetric reactions involving trifluoroethylketimine in recent five years is reviewed, and the future development of this field is prospected.
Key words: trifluoroethylketimine, asymmetric catalysis, cycloaddition, trifluoromethyl group, synthesis of chiral amine


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