摘要/Abstract

烯丙基是有机合成中常用的保护基团, 具有引入简单, 在酸/碱性及还原剂等条件下稳定, 在相对温和的条件下选择性地脱保护等特点, 在有机合成特别是药物和天然产物的合成研究中具有重要地位. 近几十年来, 研究者们对各类烯丙基的脱保护方法进行了广泛研究. 按碱及还原剂促进、氧化及自由基过程、路易斯酸促进、碘促进、过渡金属催化及电化学方法等分类, 对脱烯丙基保护方法的研究进展进行了综述.
关键词: 脱烯丙基反应, 碱促进脱烯丙基化, 过渡金属催化脱烯丙基化, 氧化脱烯丙基化, 自由基历程脱烯丙基化, 路易斯酸催化脱烯丙基化, 电化学脱烯丙基化
Allyl groups, as a kind of universal protective groups in organic synthesis, are easily introduced, and stable under acidic, basic and reductive conditions. Moreover, the deallylation may occur efficiently and selectively under mild conditions. Therefore, functional group protection with allyl moiety plays a significant role in organic synthesis, especially in the synthesis of natural products and pharmaceutical industry. In recent decades, various methods of deallylation have been developed. Herein, the comprehensive development on the deallylation reaction with base and reductant, oxidation and free radical, Lewis-acid, iodine, transition metals, and electrochemical methods is reviewed.
Key words: deallylation, base-catalyzed deallylation, transition metal catalyzed deallylation, oxidative deallylation, free radical deallylation, Lewis-acid catalyzed deallylation, electrochemical deallylation


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