摘要/Abstract

报道了在不加碱的条件下, 无配体铜盐能有效催化羧酸和氨基甲酰氯脱羧交叉偶联反应, 以CuCl₂为催化剂、苯为溶剂, 于120 ℃条件下反应48 h即可实现脱羧交叉偶联过程. 在此标准条件下, 该催化体系对官能团普适性较好, 以较高收率获得了各种酰胺, 产物经¹H NMR、¹³C NMR和HRMS表征
关键词: 铜催化, 脱羧交叉偶联, 碳-碳成键, 芳氨基甲酰氯, 酰胺
A ligand-free copper-catalyzed decarboxylative cross-coupling reaction of carboxylic acids and carbamoyl chlorides in the absence of base was developed. With CuCl₂ as the catalyst, the decarboxylative cross-coupling process could be realized in benzene at 120 ℃ in 48 h. Under the standard condition, the catalytic system had good functional group tolerance, and diverse amides were obtained in good to high yields. The structures of products were elucidated by ¹H NMR, ¹³C NMR and HRMS spectra.
Key words: copper-catalysis, decarboxylative cross-coupling, C—C bond formation, arylcarbamoyl chloride, amide


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