摘要/Abstract

从红树角果木内生真菌Penicillium herqueiJX4中分离纯化得到11个次级代谢产物, 应用质谱(MS)、核磁共振(NMR)以及圆二色谱(ECD)等多种波谱和光谱技术确定了11个次级代谢产物的结构, 经鉴定分别为Penicillquei A (1), Penicillquei B (2), Pyrophen (3), Alaromydien A (4), Penicillar E (5), Aculene D (6), Sordaricin (7), BE-31405 (8), Vermistatin (9), Aspergillumarin A (10)和Aspergillumarin B (11). 化合物1和2新化合物. 抑菌活性测试表明化合物2, 3, 7和8具有广谱的抗植物病原菌活性.
关键词: 青霉属真菌, 次级代谢产物, 抗植物病原菌活性
Two new secondary metabolites, penicillqueies A and B (1and2), together with penicillquei A (1), penicillquei B (2), pyrophen (3), alaromydien A (4), penicillar E (5), aculene D (6), sordaricin (7), BE-31405 (8), vermistatin (9), aspergillumarin A (10) and aspergillumarin B (11) were isolated from Penicillium herqueiJX4. Their structures were elucidated using comprehensive spectroscopic methods. The absolute configuration of penicillquei A was determined by its experimental and calculated electronic circular dichroism (ECD) spectra. Compounds 2,3, 7 and 8 showed broad spectrum antifungal activities against nine phytopathogenic fungi.
Key words: Penicillium herquei, secondary metabolites, antifungal activity


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