摘要/Abstract

铁作为生命系统中最丰富的过渡金属元素, 在许多生理和病理过程中发挥着无可替代的作用. 铁平衡失调不仅会导致诸如癌症、心血管疾病、神经退行性疾病等的发生和发展, 而且还会造成细胞铁死亡. 尽管细胞中的铁有Fe ²⁺和Fe ³⁺两种形式, 但细胞还原性微环境使其主要以Fe ²⁺形式存在. 因此, 开发一种对Fe ²⁺的特异性检测技术有助于深入了解Fe ²⁺与人类健康和疾病的关系. 随着荧光成像技术的发展, 近年来特异性检测Fe ²⁺的荧光探针引起****们的极大关注. 对近10年来报道的Fe ²⁺荧光探针, 根据探针的设计思路、与Fe ²⁺的作用机理、光学特性以及其生物应用等方面进行了总结, 并对Fe ²⁺荧光探针的发展前景进行了展望.
关键词: 亚铁离子, 荧光探针, 荧光成像
Irons, as the most abundant transition metal in living system, play an irreplaceable role in many physiological and pathological processes. The misregulation of Fe ²⁺ homeostasis not only affects the occurence and delelopment of various diseases, such as cancer, cardiovascular disease and neurodegenerative disorders, but also induces ferroptosis. Although two forms of iron (Fe ²⁺ and Fe ³⁺) exist in cells, reducing microenvironment of cells makes it exist mainly in the form of Fe ²⁺. Therefore, developing a sensitive approach for Fe ²⁺ is particularly important because it may contribute to the in-depth understanding of the relationship between Fe ²⁺ and human health and disease. In recent years, with the rapid development of fluorescent imaging technique, fluorescent probes for the sensitive detection of Fe ²⁺ have attracted great interest. Fe ²⁺ fluorescent probes reported in the last ten years are summarized, according to probes design, sensing mechanisms with Fe ²⁺, optical properties and biological application. In addition, the development prospect of Fe ²⁺ fluorescent probes is predicted.
Key words: s ferrous ion, fluorescent probe, fluorescent imaging


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