摘要/Abstract

中环（7～9元环）化合物广泛存在于各类具有重要生物活性的天然产物中，发展它们的经济高效的合成方法一直以来受到了密切的关注.总结了近年来通过过渡金属催化的不饱和键对C—H键的插入反应来构建中环化合物的反应.按照使用的金属中间体稳定策略的不同，把这些合成方法分为四类，并从各自的发展、特点、反应类型和反应机理等方面进行了阐述.
关键词: 中环化合物, 过渡金属催化, π-不饱和键, C—H键
Medium rings (7~9 membered) widely exist in a variety of natural products that often have important bio-activities, thereby the development of economical and highly efficient synthetic routes to them has received intensive attention. Recent advances on transition metal-catalyzed π-unsaturated compounds inserting into C-H bonds for the construction of medium rings are summarized. According to different strategies that were used to stabilize organometallic intermediates, these methods can be divided into four types, and each of which was described from various aspects including its progress, characteristics, reaction types and mechanisms.
Key words: medium-ring compound, transition metal catalysis, π-unsaturated bond, C-H bond


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