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电化学促进的N-烯丙基硫代酰胺的硒化/环化合成2-噻唑啉

本站小编 Free考研考试/2022-02-14

摘要/Abstract



建立了一种电化学促进N-烯丙基硫代酰胺的串联硒化/环化新方法,用来制备含硒官能团的2-噻唑啉衍生物.该方法反应条件温和,底物范围广.初步的机理研究表明,反应过程中有硒自由基的参与.该方法操作简单且无需使用催化剂、过渡金属和氧化剂.
关键词: 电合成, 噻唑啉, 硫代酰胺, 硒化
An electrochemical selenylation/cyclization of N-allylthioamides has been developed for the synthesis of selenium-containing 2-thiazolines. This protocol provides an efficient approach to produce 2-thiazolines with broad substrate scope under mild reaction conditions. Preliminary mechanistic study indicates that selenium radical may be involved. The reaction is easy operated under catalyst- and oxidant-free conditions.
Key words: electrosynthesis, thiazolines, thioamides, selenation


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