摘要/Abstract

发展一种银催化1-溴代炔烃的官能团反应，用于高度区域和立体选择性合成（Z）-β-溴-1-芳基乙烯基芳基酯.以市售的芳香羧酸为原料，Ag₂O为催化剂，以Et₃N为碱，1-溴炔烃与芳香羧酸反应，高收率得到相应的（Z）-β-溴-1-芳基乙烯基芳基酯产物.研究结果表明，Ag₂O在反应中起着重要的催化作用.
关键词: 1-溴炔, (Z)-β-溴-1-芳基乙烯基芳基酯, 银催化, 区域选择性, 立体选择性
A silver-catalyzed functionalization of 1-bromoalkynes for the highly regio-and stereo-selective synthesis of (Z)-β-bromo-1-arylvinyl aryl esters was developed. In the presence of Ag₂O as a catalyst, and Et₃N as a base, the reactions of 1-bromoalkynes with commercially available aromatic carboxylic acids underwent smoothly to afford the corresponding (Z)-β-bromo-1-arylvinyl aryl esters in good yields. The investigation indicates that Ag₂O plays an important role in the reaction.
Key words: 1-bromoalkynes, (Z)-β-bromo-1-arylvinyl aryl esters, silver catalysis, regio-selectivity, stereo-selectivity


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