摘要/Abstract
以NiCl2为催化剂催化N-四氢异喹啉的分子氧氧化脱氢偶联反应，以较高产率制备了一系列N-芳基四氢异喹啉化合物.该方法对不同的N-四氢异喹啉衍生物和亲核试剂均具有较好的适用性，反应均能以较高的产率获得相应的目标产物.与已有方法相比，本方法采用分子氧为氧化剂，具有反应条件温和、底物适用范围广、操作简便等优点，为四氢异喹啉衍生物的制备提供了一种有效途径.
关键词: 脱氢偶联, C—H活化, 镍, 分子氧, N-芳基四氢异喹啉
An nickel-catalyzed aerobic cross-dehydrogenative coupling of N-aryl tetrahydroisoquinolines is presented. The catalytic system could tolerate various N-aryl tetrahydroquinoline derivatives and nucleophiles, and the target products could be obtained in good to excellent yields. Compared with reported methods, the protocol uses molecular oxygen as a sustainable oxidant, and provides an effective approach to the synthesis of tetrahydroisoquinoline derivatives under mild and practical conditions.
Key words: cross-dehydrogenative coupling, C-H activation, nickel, molecular oxygen, N-aryl tetrahydroisoquinoline
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