摘要/Abstract
6α和6β-羟基去氧胆酸[DCA-6α-ol（6）和DCA-6β-ol（7）]是新近鉴定的两个来自于人类肝脏的重要三级胆汁酸代谢产物.以胆酸（1）为起始原料经10步反应方便快捷地同时实现DCA-6α-ol（6）和DCA-6β-ol（7）的合成.路线涉及Mukaiyama羟醛缩合、臭氧裂解和SmI2促进的羰基邻位还原脱氧等关键反应.
关键词: 胆汁酸, 6α-羟基去氧胆酸, 6β-羟基去氧胆酸, 合成
6α- and 6β-hydroxydeoxycholic acids[DCA-6α-ol (6) and DCA-6β-ol (7)] are recently identified important tertiary bile acids derived from deoxycholic acid (3) in human liver. A rapid and robust synthesis of DCA-6α-ol (6) and DCA-6β-ol (7) from cholic acid (1) in 10 steps involing the key Mukaiyama aldol condensation, ozone oxidative cleavage and SmI2 promoted reductive deoxygenation was conducted.
Key words: bile acid, 6α-hydroxydeoxycholic acid, 6β-hydroxydeoxycholic acid, synthesis
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