摘要/Abstract
吩嗪-1-羧酸是一种广泛存在于假单胞菌和链霉菌等微生物的次级代谢产物, 对植物病原菌具有很好的抑制活性, 同时兼具医用杀菌及抗肿瘤等活性. 综述了吩嗪-1-羧酸的生物合成与化学合成, 并对目前吩嗪-1-羧酸天然类似物以及化学合成类似物的生物活性研究进行了总结, 为此类化合物的结构改造与活性研究提供参考.
关键词: 吩嗪-1-羧酸, 类似物, 研究进展
Phenazine-1-carboxylic acid (PCA) as a natural product widely exists in microbial metabolites of Pseudomonads and Streptomycetes, which displays potent inhibitory activities against plant pathogens, and has medical antibacterial and antitumor effects, and so on. In this review, the biosynthesis and chemosynthesis of phenazine-1-carboxylic acid are summarized. At the same time, the diverse biological evaluations of its biosynthetic and chemosynthetic analogues are summarized, which could provide reference for the study of structural modifications and biological activities of these analogues.
Key words: phenazine-1-carboxylic acid, analogues, research progress
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