摘要/Abstract

手性化合物在不对称合成、生物学和医药学等领域发挥着重要作用，建立快速、灵敏、高选择性的手性分析方法意义重大.手性传感器因其在确定对映体的绝对构型及对映体过量值中具有简单、快速、灵敏和实时等优点，备受研究者的青睐.聚焦于荧光传感器、圆二色谱传感器、紫外-可见传感器、核磁传感器和质谱传感器，主要介绍了各种传感器的特点及原理，综述了近年来它们在手性识别中的应用，并展望了手性传感器的发展前景.
关键词: 手性传感器, 手性化合物, 手性识别, 对映体过量百分数, 绝对构型
Chiral compounds play an essential role in asymmetric synthesis, biology, medical field and pharmacology. It is necessary to establish fast, sensitive and high enantioselective chiral analysis methods. Chiral sensors, which could determine the absolute configuration and the value of enantiomeric excess of enantiomers, have the advantages of simple, rapid, sensitive and real-time. Herein, the review is focused on the recent progress of chiral fluorescent sensors, circular dichroism sensors, UV-Vis sensors, NMR sensors and MS sensors. Their characteristics, sensing mechanism and applications in chiral recognition are reviewed, and the prospects of chiral sensors are also discussed.
Key words: chiral sensor, chiral compound, chiral recognition, enantiomeric excess, absolute configuration


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