摘要/Abstract

异苯并呋喃酮类化合物广泛存在于自然界中，并具有广泛的生物活性.报道了以邻羧基苯甲醛和不同取代的苯乙酮为原料，苯胺促进的串联反应构建异苯并呋喃酮类骨架结构的合成新方法，该方法具有适用范围广、反应条件温和、高产率和简单易处理等优点，为异苯并呋喃酮类化合物的合成提供了新思路.
关键词: 异苯并呋喃酮, 苯胺, 串联反应
Isobenzofuranone derivatives are widely found in nature and have shown diverse biological activities. In this work, the aniline-promoted synthesis of isobenzofuranone derivatives starting from 2-carboxybenzaldehyde and substituted acetophenones under mild reaction conditions is reported. This method has broad substrate scope, high yields, and is operationally convenient, and therefore could serve as an attractive strategy for practical synthesis of isobenzofuranone derivatives.
Key words: isobenzofuranone derivatives, aniline, cascade reactions


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