摘要/Abstract
镜像蛋白质由D型α-氨基酸及甘氨酸构成，与天然蛋白质互为手性对映体.镜像蛋白质尚无法通过生物重组技术制备，而只能通过化学全合成获取.镜像蛋白质具有独特的结构和功能，使其在外消旋结晶、仿生催化、软物质材料、疾病诊断与治疗物质等方面具备潜在的应用价值.简要介绍了镜像蛋白的化学合成方法，总结了镜像D型蛋白质在蛋白外消旋结晶、蛋白药物开发以及镜像生命再造方面取得的进展.
关键词: 镜像蛋白质, 蛋白化学合成, 外消旋结晶, 镜像噬菌体展示, 镜像生命体系
Mirror-image proteins are composed of D-amino acids and glycine. They are the enantiomers of the native L-protein counterparts. Currently mirror-image proteins can not be obtained through recombinant technology and therefore, chemical synthesis is the only way to generate mirror-image proteins. As structurally defined and functionally variable chemical materials, mirror-image proteins have potential applications in racemic crystallography, biomimetic catalysis, soft materials, and diagnostics and therapeutic reagents. The chemical synthesis of mirror-image proteins and the advances in racemic X-ray crystallography, mirror-image drug discovery, as well as mirror-image biological systems are surveyed.
Key words: mirror-image protein, protein chemical synthesis, racemic crystallography, mirror-image phage display, mirror-image biosystem
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