摘要/Abstract

吲哚化学的研究是杂环化学中最活跃的领域之一，特别是有关3-取代吲哚衍生物的合成.3-取代吲哚衍生物可以构建许多天然产物和相应具有生物活性化合物，其合成方法的研究格外令人关注.介绍了在微波辐射下，通过取代苯甲酰甲醛水合物、取代苯胺和4-羟基香豆素三组分，在三氟乙酸的催化下反应构建一系列官能团化的3-取代吲哚衍生物.该反应具有反应操作简单、原料廉价易得及原子经济性高等优点.
关键词: 吲哚, 合成, 三组分反应, 微波
The research of indoles has been one of the most active areas of heterocyclic chemistry. In particular, 3-substituted indole derivatives have received much attention as building blocks for the synthesis of many natural products and other biologically active compounds. In this article, an synthetic procedure for multi-substituted indole derivatives was successfully developed by a three-component reaction of phenylglyoxal monohydrate, aromatic amine and 4-hydroxycoumarin with a catalytic amount of trifluoroacetic acid under microwave irradiation conditions. This method has the advantages of simple operation, readily available raw materials, and high atom utilization.
Key words: indole, synthesis, three-component reaction, microwave


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