摘要/Abstract

卤代苯腈是医药、农药、材料等领域的重要原料，含有腈基与卤素两个可与亲核试剂反应的活性位点.本文总结了卤代苯腈与不同硫化物反应合成卤代硫代苯甲酰胺或巯基苯腈的规律，发现在酸性条件下主要生成卤代硫代苯甲酰胺，在碱性条件下主要生成巯基苯腈.
关键词: 硫属, 杂原子化合物, 合成方法, 卤代苯腈, 卤代硫代苯甲酰胺, 巯基苯腈
Halobenzonitrile is an important raw material in the fields of medicine, pesticide and materials. Halobenzonitrile has a nitrile group and a halo group which all could react with nucleophile reagents. The law for the selective synthesis of halothiobenzamide or mercaptobenzonitrile from the reaction of halobenzonitrile and different sulfur source is summarized. It is found that the halothiobenzamide product could be synthesized under protonic acid condition from halobenzonitrile, while the mercaptobenzonitrile product would be formed under the alkaline conditions.
Key words: chalcogens, heteroatom compounds, synthetic methods, halobenzonitrile, halothiobenzamide, mercaptobenzonitrile


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