外周炎症促发帕金森病的神经机制研究进展
刘泳廷¹, 孙铭浩¹, 蔡春伟¹, 任超², 牛海晨^3,*
1徐州医科大学临床医学系，徐州 221004；²青岛大学附属烟台毓璜顶医院神经内科，烟台 264000；3徐州医科大学遗传教研室，徐州 221004；³徐州医科大学遗传教研室，徐州 221004
摘要
帕金森病(Parkinson’s disease, PD)是发病率排名第二位的中枢神经系统退行性疾病，其病理特点是黑质致密部多巴胺能神经元丢失。对PD患者的尸检分析和实验动物研究显示小胶质细胞激活和炎症因子水平的升高是PD脑组织的共同特征。同时研究显示PD患者病变脑区及毗邻区域检测到来自周围的免疫细胞的浸润和积聚。本文对外周炎症跨血脑屏障(blood-brain barrier, BBB)、错误折叠的α-突触核蛋白(α-synuclein, α-syn)引发小胶质细胞激活和PD脑内炎症等方面进行总结，为延缓PD发病提供潜在治疗措施。


关键词： 帕金森病; 外周炎症; α-突触核蛋白; 血脑屏障; 小胶质细胞
分类号：R338

Research progress on neural mechanism of peripheral inflammation in Parkinson’s disease
LIU Yong-Ting¹, SUN Ming-Hao¹, CAI Chun-Wei¹, REN Chao², NIU Hai-Chen^3,*
1Department of Clinical Medicine, Xuzhou Medical University, Xuzhou 221004, China；²Department of Neurology, Yantai Yuhuangding Hospital, Qingdao University, Yantai 264000, China; 3Department of Genetics, Xuzhou Medical University, Xuzhou 221004, China；³Department of Genetics, Xuzhou Medical University, Xuzhou 221004, China
Abstract
Parkinson’s disease (PD) is the second most common neurodegenerative disease, characterized by loss of dopaminergic (DA) neurons in the dense part of the substantia nigra (SNpc). Postmortem analysis of PD patients and experimental animal studies found that microglial cell activation and increased levels of pro-inflammatory factors were common features of PD brain tissue. At the same time, the invasion and accumulation of peripheric immune cells were detected in the brain of PD patients. In this paper, peripheral inflammation across the blood-brain barrier (BBB), the misfolded α-synuclein (α-syn)-induced microglial cell activation and intracerebral inflammation in PD are summarized, providing potential therapeutic measures for delaying the onset of PD.


Key words: Parkinson’s disease; peripheral inflammation; α-synuclein; blood-brain barrier; microglial cell

收稿日期：2019-02-23　　录用日期：2019-05-20
通讯作者：牛海晨　　E-mail: nhcnhc@163.com
DOI: 10.13294/j.aps.2019.0053
引用本文：
刘泳廷, 孙铭浩, 蔡春伟, 任超, 牛海晨. 外周炎症促发帕金森病的神经机制研究进展[J]. 生理学报 2019; 71 (5): 732-740.
LIU Yong-Ting, SUN Ming-Hao, CAI Chun-Wei, REN Chao, NIU Hai-Chen. Research progress on neural mechanism of peripheral inflammation in Parkinson’s disease. Acta Physiol Sin 2019; 71 (5): 732-740 (in Chinese with English abstract).



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