SOS1蛋白病理生理功能研究进展
郝佩琪¹, 张新宇¹, 郭慧^1,2, 杨洋¹, 安输¹, 刘莹¹, 郭晓汐¹, 徐天瑞¹, 郝倩^1,*
1昆明理工大学生命科学与技术学院，云南省高校靶点药物筛选与利用重点实验室，昆明 650500；²云南省第一人民医院，昆明理工大学附属医院，昆明 650032
摘要
SOS1 (son of sevenless homolog 1)蛋白是一种在细胞中广泛表达的调控蛋白。作为信号通路中的关键蛋白，SOS1在细胞内许多信号转导通路中起着重要的调控作用，例如参与调控Ras和Rac信号通路。SOS1的异常表达或突变与临床疾病的发生密切相关。本文对SOS1的功能及其在生理学、病理生理学中的作用的研究进展进行综述。


关键词： SOS1; Ras; Rac; 努南综合征
分类号：Q7

Research progress on pathophysiological function of SOS1 protein
HAO Pei-Qi¹, ZHANG Xin-Yu¹, GUO Hui^1,2, YANG Yang¹, AN Shu¹, LIU Ying¹, GUO Xiao-Xi¹, XU Tian-Rui¹, HAO Qian^1,*
1Faculty of Life Science and Technology, Kunming University of Science and Technology, University Based Provincial Key Laboratory of Screening and Utilization of Targeted Drugs, Kunming 650500, China；²The First People’s Hospital of Yunnan Province, the Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, China
Abstract
Son of sevenless homolog 1 (SOS1) protein is a ubiquitously expressed adapter. As a key protein in intracellular signaling, SOS1 plays an important role in many signal transduction pathways, such as Ras and Rac signaling pathways. The abnormal expression or mutation of SOS1 is closely related to clinical diseases. In this article, we review research progress on SOS1 functions and its roles in physiology and pathophysiology.


Key words: SOS1; Ras; Rac; Noonan syndrome

收稿日期：2018-01-25　　录用日期：2018-09-21
通讯作者：郝倩　　E-mail: haoqian26@126.com
DOI: 10.13294/j.aps.2018.0063
引用本文：
郝佩琪, 张新宇, 郭慧, 杨洋, 安输, 刘莹, 郭晓汐, 徐天瑞, 郝倩. SOS1蛋白病理生理功能研究进展[J]. 生理学报 2018; 70 (5): 565-570.
HAO Pei-Qi, ZHANG Xin-Yu, GUO Hui, YANG Yang, AN Shu, LIU Ying, GUO Xiao-Xi, XU Tian-Rui, HAO Qian. Research progress on pathophysiological function of SOS1 protein. Acta Physiol Sin 2018; 70 (5): 565-570 (in Chinese with English abstract).



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