核受体与肾脏水转运调节
王冰, 张晓燕^*
大连医科大学医学科学研究院，大连 116044
摘要
肾脏通过调节尿液的浓缩和稀释来维持机体的水平衡状态。水通道是肾脏生成尿液、调控水转运的分子基础，其表达和膜转位受到精细的调控。核受体是一组转录因子超家族，人核受体有48个成员，它们通过对靶基因的调控广泛参与机体的生长发育、糖脂代谢、炎症、免疫等多种生理及病理生理过程。近年来，越来越多的研究揭示核受体调节水通道的表达和膜转位，进而在机体水稳态维持中发挥重要的调控作用。本文将主要探讨核受体在肾脏水转运调控中的作用和机制。
关键词： 核受体; 水转运
分类号：R334

Nuclear receptors and renal water transport regulation
Wang Bing, ZHANG Xiao-Yan^*
Advanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China
Abstract
The function of kidney is maintaining water balance of our body through regulation of urine concentration and dilution. The aquaporins are molecular basis of renal urine production and water transport, and their expression and membrane translocation are regulated delicately. Nuclear receptors are a superfamily of ligand-activated transcription factors consisting of 48 members in human. They widely participate in a variety of physiological and pathophysiological regulation including growth and development, glucose and lipid metabolism, inflammation, immunology by regulating target gene transcription and expression. Increasing evidence demonstrates that these receptors are involved in the regulation of aquaporins expression and membrane translocation in kidney, thereby playing a major role in water homeostasis. Here we review the role of nuclear receptors in regulating renal water transport.


Key words: nuclear receptors; water transport

收稿日期：2018-06-05　　录用日期：2018-10-07
通讯作者：张晓燕　　E-mail: zhangxy@dmu.edu.cn
DOI: 10.13294/j.aps.2018.0073
引用本文：
王冰, 张晓燕. 核受体与肾脏水转运调节[J]. 生理学报 2018; 70 (6): 630-638.
Wang Bing, ZHANG Xiao-Yan. Nuclear receptors and renal water transport regulation. Acta Physiol Sin 2018; 70 (6): 630-638 (in Chinese with English abstract).



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