何云刚
博士，青年研究员
地址：东安路 131号，明道楼，上海 200032
邮箱：heyungang@fudan.edu.cn




工作经历
青年研究员复旦大学，生物医学研究院，(2018.1-今)
副研究员中国科学院，中科院-马普学会计算生物学伙伴研究所，(2009.11-2017.12)
博士后美国斯坦福研究院，(2006.4-2008.4)


教育经历
博士复旦大学，生命科学学院，(2002-2005)
硕士云南大学，生命科学学院，(1999-2002)
学士云南大学，生物系，(1995-1999)
所获奖项
所获奖项获奖名称授予单位时间
自然科学二等奖（第四完成人）国务院2015
自然科学一等奖（第四完成人）教育部2012

研究方向
课题组运用计算生物学及统计和进化遗传学方法分析丰富的实验数据，研究人类疾病及其他表型发生发展的遗传学基础，探索基因组多样性引起个体表型差异的遗传机制。此外课题组还对耐药性进化机制等治疗相关的遗传进化问题展开研究。
课题组长何云刚主持和参与多项国家和省部级项目，包括国家重点研发计划、国家自然科学基金重大研究计划、面上项目、上海市科委项目等。在国内外学术刊物上发表论文30余篇，部分发表在Genome Res.， Cell Res.， Proc. Natl. Acad. Sci. U S A.，Mol Biol Evol.等国际著名期刊。

代表论文
1. Dong H., Zhou B., Kang H., Jin W., Zhu Y., Shen Y., Sun J., Wang S., Zhao P., Hou J., He Y^*. Small surface antigen variants of hepatitis B virus associated with chronic hepatitis B patients’ responses to telbivudine treatment. Antivir Ther. 2017;22(1):43-51.
2. Xu H.^#, Yang Y.^#, Wang S., Zhu R., Qiu T., Qiu J., Zhang Q., Jin L., He Y^*., Tang K.^*, Cao Z.^* Predicting the Mutating Distribution at Antigenic Sites of the Influenza Virus. Sci Rep. 2016 Feb 3;6:20239. doi: 10.1038/srep20239.
3. He Y.^*, Wang M., Huang X., Li R., Xu H., Xu S., Jin L.^* A probabilistic method for testing and estimating selection differences between populations. Genome Res. 2015 Dec;25(12):1903-9. doi: 10.1101/gr.192336.115. Epub 2015 Oct 13.
4. Zhou B.^#, Dong H.^#, He Y.^#, Sun J.^#, Jin W.^#, Xie Q., Fan Rong., Wang M., Li Ran., Chen Y., Xie S., Shen Y., Huang X., Wang S., Lu F., Jia J., Zhuang H., Locarnini S., Zhao GP.^*, Jin L.^*, Hou J.^* Composition and Interactions of Hepatitis B virus quasispecies defined the virological response during telbivudine therapy. Sci Rep 2015 Nov 24;5:17123. doi: 10.1038/srep17123.
5. Wang M., Huang X., Li R., Xu H., Jin L*., He Y*. Detecting Recent Positive Selection with High Accuracy and Reliability by Conditional Coalescent Tree. Mol Biol Evol. 2014 31(11):3068-3080.
6. Jiang Y., Wang M., Zheng H., Wang WR., Jin L.^*, He Y.^* Resolving ambiguity in the phylogenetic relationship of genotypes A., B., and C of hepatitis B virus. BMC Evol Biol. 2013 Jun 11;13:120.
7. He Y.^*, Wang WR., Xu S., Jin L.^* Snp Consortium PA. Paleolithic Contingent in Modern Japanese: Estimation and Inference using Genome-wide Data. Sci Rep. 2012 Apr;2:355
8. He Y., Xu S., Jia C., Jin L^*. A design of multi-source samples as a shared control for association studies in genetically stratified populations. Cell Res. 2009 Jul;19(7):913-915
9. He Y., Bergen AW., Hops H., Andrews JA., Tildesley E., Lessov-Schlaggar CN., Webster C., Benowitz N., Swan GE.^* Genome-wide Linkage of Cotinine Pharmacokinetics Suggests Candidate Regions on Chromosomes 9 and 11. Am J Med Genet B Neuropsychiatr Genet. 2009 Jun 5;150B(4):554-559
10. He Y*., Jiang R., Fu W., Bergen AW., Swan GE., Jin L. Correlation of Population Parameters Leading to Power Differences In Association Studies with Population Stratification. Ann Hum Genet. 2008 72:801-811
11. Huang W.^#, He Y.^#, Wang H.^#, Wang Y.^#, Liu Y.^#, Wang Y., Chu X., Wang Y., Xu L., Shen Y., Xiong X., Li H., Wen B., Qian J., Yuan W., Zhang C., Wang Y., Jiang H., Zhao G., Chen Z^*., Jin L^*. Linkage disequilibrium sharing and haplotype-tagged SNP portability between populations. Proc. Natl. Acad. Sci. U S A. 2006., 103: 1418-1421