胡璐璐
博士，青年研究员
地址：上海市医学院路138号，上海 200032
电话：
传真：
邮箱：luluhu@fudan.edu.cn


工作经历
研究员，复旦大学，生物医学研究院（2020.11-至今）
博士后 芝加哥大学（2015.2-2020.9）

教育经历
博士，复旦大学，生物医学研究院（2009.9-2014.6）
学士，苏州大学，生命科学学院（2005.9-2009.6）
所获人才项目

所获奖项
Excellent Ph. D of Fudan University and Shanghai City，2014
Graduate Star of Scientific Research of Fudan University，2014
Chicago Fellow Award，2015-2017
The Chicago Biomedical Consortium (CBC) fellowship，2016-2017
Leukemia & Lymphoma Society Special Fellow，2017-2020
研究方向
RNA m⁶A修饰在癌症发生、造血干细胞分化、早期胚胎发育中的功能；开发新的RNA修饰的二代测序新方法；开发不依赖于近端连接的检测DNA-DNA，DNA-RNA，RNA-RNA相互作用的新技术；开发超小量细胞的Chip-seq, Rip-seq的新技术；运用晶体学以及冷冻电镜研究RNA表观遗传学领域重要大分子复合物的结构。
代表论文

1: In submission: Quantitative RNA m⁶A sequencing reveals dynamic modulation of human monocyte differentiation
Lulu Hu^{1, 2, 3#},Shun Liu^{1,2, 3, 4, 5#}, Yong Peng^{1,2,3, 4, 5#}, Ruiqi Ge^{1,2, 3#}, Rui Su^6#, Chamara Senevirathne⁷, Bryan T. Harada^{1,2, 3}, Qing Dai^1,2,3, Jiang bo Wei^{1, 2,3}, Lisheng Zhang^{1,2, 3}, Ziyang Hao^1,2,3, Liangzhi Luo^{1, 2, 3}, Huanyu Wang^{1, 2, 3}, Yuru Wang^1,2,3, Mingkui Luo⁷, Jianjun Chen⁶, ⁸*, Mengjie Chen^4,5* & Chuan He^{1,2, 3}*

2: Hu L*, Liu Y*, Han S*, Yang L*, Cui X, Gao Y, Dai Q, Lu X, Kou X, Zhao Y, Sheng W, Gao S, He X, He C. Jump-seq: Genome-Wide Capture and Amplification of 5-Hydroxymethylcytosine Sites. J Am Chem Soc. 2019 Jun 5;141(22):8694-8697. doi: 10.1021/jacs.9b02512. Epub 2019 May 23.

3: Zhang LS, Liu C, Ma H, Dai Q, Sun HL, Luo G, Zhang Z, Zhang L, Hu L, Dong X, He C. Transcriptome-wide Mapping of Internal N7-Methylguanosine Methylome in Mammalian mRNA. Mol Cell. 2019 Jun 20;74(6):1304-1316.e8. doi: 10.1016/j.molcel.2019.03.036. Epub 2019 Apr 25.

4: Ji L, Jordan WT, Shi X, Hu L, He C, Schmitz RJ. TET-mediated epimutagenesis of the Arabidopsis thaliana methylome. Nat Commun. 2018 Mar 1;9(1):895. doi: 10.1038/s41467-018-03289-7.

5: Wang W, Xu L, Hu L, Chong J, He C, Wang D. Epigenetic DNA Modification N6-Methyladenine Causes Site-Specific RNA Polymerase II Transcriptional Pausing. J Am Chem Soc. 2017 Oct 18;139(41):14436-14442. doi: 10.1021/jacs.7b06381. Epub 2017 Oct 3.

6: Lu J, Hu L*, Cheng J, Fang D, Wang C, Yu K, Jiang H, Cui Q, Xu Y, Luo C. A computational investigation on the substrate preference of ten-eleven-translocation 2 (TET2). Phys Chem Chem Phys. 2016 Feb 14;18(6):4728-38. doi: 10.1039/c5cp07266b. (*represents equal contribution).

7: Hu L, He C. Detecting hepatocellular carcinoma in blood. Cell Res. 2015 Dec;25(12):1279-80. doi: 10.1038/cr.2015.136. Epub 2015 Nov 24.

8: Hu L*, Lu J*, Cheng J*, Rao Q, Li Z, Hou H, Lou Z, Zhang L, Li W, Gong W, Liu M, Sun C, Yin X, Li J, Tan X, Wang P, Wang Y, Fang D, Cui Q, Yang P, He C, Jiang H, Luo C, Xu Y. Structural insight into substrate preference for TET-mediated oxidation. Nature2015 Nov 5;527(7576):118-22. (*represents equal contribution).

9:Hu L*, Li Z*, Cheng J*, Rao Q, Gong W, Liu M, Shi YG, Zhu J, Wang P, Xu Y. Crystal structure of TET2-DNA complex: insight into TET-mediated 5mC oxidation. Cell 2013 Dec 19;155(7):1545-55 (*represents equal contribution).

10: Hu L*, Li Z*, Wang P, Lin Y, Xu Y. Crystal structure of PHD domain of UHRF1 and insights into recognition of unmodified histone H3 arginine residue 2. Cell Res.2011 Sep;21(9):1374-8 (*represents equal contribution).

11: Rajakumara E*, Wang Z*, Ma H, Hu L, Chen H, Lin Y, Guo R, Wu F, Li H, Lan F, Shi YG, Xu Y, Patel DJ, Shi Y. PHD finger recognition of unmodified histone H3R2 links UHRF1 to regulation of euchromatic gene expression. Mol. Cell 2011 Jul 22;43(2):275-84 (*represents equal contribution).

12: Yang Y*, Hu L*, Wang P*, Hou H, Lin Y, Liu Y, Li Z, Gong R, Feng X, Zhou L, Zhang W, Dong Y, Yang H, Lin H, Wang Y, Chen CD, Xu Y.Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans. Cell Res. 2010 Aug;20(8):886-98 (*represents equal contribution).