教授
电话：
邮箱：zhaotj@fudan.edu.cn
地址：复旦大学2号交叉学科楼D7021室

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个人简介
1998年进入山东大学，2002年获得学士学位；2007年获得清华大学博士学位；2007-2012年，在美国西南医学中心分子遗传系进行博士后研究；2012-2014年，任美国西南医学中心分子遗传系助理教授（research track）；2014-2019年，任厦门大学生命科学学院教授；2019-今，任复旦大学代谢与整合生物学研究院教授。
主要研究方向
主要从事代谢性疾病生理和分子机制方面的研究。目前的研究工作主要集中在两个方面：1、蛋白质棕榈酰化转移酶在机体代谢调控方面的作用及其分子机制；2、脂肪细胞分化发育过程中关键调控因子的鉴定。
荣誉及获奖情况
2011年 Award for Excellence in Postdoctoral Research, UT Southwestern Medical Center
2006年 教育部自然科学一等奖 (第五完成人)
代表性成果
Ou Z#, Ma Y#, Sun Y#, Zheng G, Wang S, Xing R, Chen X, Han Y, Wang J, Lu QR*, Zhao TJ*, Chen Y*. A GPR17-cAMP-Lactate Signaling Axis in Oligodendrocytes Regulates Whole-Body Metabolism. Cell Rep, 2019,26: 2984-2997.
Wang J#, Hao JW#, Wang X#, Guo H#, Sun HH, Lai XY, Liu LY, Zhu M, Wang HY, Li YF, Yu LY, Xie C, Wang HR, Mo W, Zhou HM, Chen S, Liang G, Zhao TJ*.DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane. Cell Rep, 2019, 26: 209-221.
Liu M#, Zeng T#, Zhang X#, Liu C, Wu Z, Yao L, Xie C, Xia H, Lin Q, Xie L, Zhou D, Deng X, Chan HL, Zhao TJ*, Wang HR*. ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage. Nat Commun, 2018, 9: 4139.
Zhang Y, Fang F, Goldstein JL*, Brown MS*, Zhao TJ.Reduced autophagy in livers of fasted, fat-depleted ghrelin-dificient mice: reversal by growth hormone. Proc Natl Acad Sci USA, 2015,112: 1226-1231.
McFarlane MR, Brown MS*, Goldstein JL*, Zhao TJ. Induced Ablation of Ghrelin Cells in Adult Mice Does Not Decrease Food Intake, Body Weight, or Response to High-Fat Diet. Cell Metab, 2014,20: 54-60.
Li RL#, Sherbet DP#, Elsbernd BL, Goldstein JL*, Brown MS*, Zhao TJ.Profound hypoglycemia in starved, ghrelin-deficient mice is caused by decreased gluconeogenesis and reversed by lactate or fatty acids. J Biol Chem, 2012, 287: 17942-17950.
Zhao TJ#, Sakata I#, Li RL, Liang G, Richardson JA, Brown MS*, Goldstein JL*, Zigman JM*. Ghrelin secretion stimulated by β1-adrenergic receptors in cultured ghrelinoma cells and in fasted mice. Proc Natl Acad Sci U S A, 2010, 107: 15868-15873. (From the cover)
Zhao TJ#, Liang G#, Li RL, Xie X, Sleeman MW, Murphy AJ, Valenzuela DM, Yancopoulos GD, Goldstein JL*, Brown MS*. Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice. Proc Natl Acad Sci U S A, 2010, 107: 7467-7472. (From the cover)
Yang J#, Zhao TJ#, Goldstein JL*, Brown MS*. (2008) Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptides. Proc Natl Acad Sci U S A, 2008, 105: 10750-10755. (Co-first author)
Qi J#, Gong J#, Zhao TJ#, Zhao J, Lam P, Ye J, Li JZ, Wu J, Zhou HM*, Li P*.Downregulation of AMP-activated protein kinase by Cidea-mediated ubiquitination and degradation in brown adipose tissue. EMBO J, 2008,27: 1537-1548. (Co-first author)