青年研究员
邮箱：b**@ntu.edu.tw

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个人简介
2018-2020年 美国圣路易华盛顿大学医学院，免疫及病理学系，讲师
2014-2018年 美国圣路易华盛顿大学医学院，免疫及病理学系，博士后
2007-2013年 美国达特茅斯医学院, 生化系，博士
主要研究方向
研究脂蛋白（包括高/低密度脂蛋白、乳糜微粒）如何从组织通过淋巴管回到血液的过程，以及这个过程如何被免疫调控及影响代谢而导致心血管，肠道及自体免疫疾病。研究的特点在于利用多领域多学科包括免疫、代谢、淋巴管、脂蛋白和生化技术来解决单一学科不容易解决的问题；并整合细胞，小鼠和人类临床转化的方法来实现新药开发以减缓疾病的进程。
荣誉及获奖情况
2019 Kern Lipid Conference Early Career Investigator Award
2019 Lymphatic Education & Research Network (LE&RN) Travel Award
2019 American Association of Immunologists Trainee Abstract Award
2018 Best Poster Award, Lipoprotein Metabolism Gordon Conference, Waterville Resort, NH
2018 American Heart Association Career Development Award
2018 Travel Award, HDL Workshop in ATVB, San Francisco, CA
2017 Best Poster Award, Sixth Annual Cardiovascular Research Day, St. Louis, MO
2017 FASEB MARC Travel Award
2017 Lymphatic Education & Research Network (LE&RN) Travel Award
2016 Best Poster Award, Fifth Annual Cardiovascular Research Day, St. Louis, MO
2016 Best Travel Award, Lipoprotein Metabolism Gordon Conference, Waterville Resort, NH
2016 Lymphatic Education & Research Network (LE&RN) Travel Award
2014 Institutional Training Grant (T32), Department of Pathology & Immunology Washington University
2014 Best Poster Award, Lipoprotein Metabolism Gordon Conference, Waterville Resort, NH
代表性成果
Huang L H, Parakkal D, Ciorba M A, Mittendorfer B, Patterson B W, Randolph G J. TNF-targeting Therapeutics selectively increase postprandial chylomicron output and endocrine hormone secretion in subjects with active crohn’s disease.2020 Gastroenterology, 159 (5):1955-1957.
Baba. O., Huang, L.H., Elvington, A., Szpakowska, M., Sultan, D., Heo, G., Zhang, X., Luehmann, H.,Detering, L., Chevigne, A., Liu, Y., Randolph, G. J.. CXCR4-binding PET tracers link monocyte recruitment and endothelial injury in murine atherosclerosis. 2020. Arteriosclerosis, Thrombosis, and Vascular Biology. (accepted)
Williams, J W, Huang, L H, Randolph, G J. Cytokine circuits in cardiovascular disease. Immunity,2019,50 (4), 941-954.
Huang L H, Zinselmeyer B H, Chang C H, Saunders B T, Kim B S, Wiig H, Thomas M J, Sorci-Thomas M G, Randolph G J. Interleukin 17-driven trapping of tissue lipoproteins links immunity to cardiovascular risk in murine psoriasis. Cell Metabolism, 2019, 29, 475-487.
Huang L H, Melton E, Sohn P, Jung D Y, Tsai C Y, Ma T, Sano H, Ha H, Friedline R, Kim J, Usherwood E,Chang C C, Chang T Y. Myeloid-specific ACAT1 gene ablation in mouse reduces adipose tissue macrophage content, improves insulin sensitivity and suppresses diet-induced obesity. American Journal of Physiology-Endocrinology and Metabolism, 2018, 315(3): E340-E356.
Huang L H, Kavine K J, Randolph G J. Cardiac lymphatic Vessels, transport, and healing of the infarcted heart. Journal of the American College of Cardiology-Basic Transl Sci., 2017, 2 (4): 477-483.
Huang L H, Sohn P, Melton E, Jung D Y, Rogers M A, Sano H, Ma T, Fiering S N, Ha H K, Friedline R H,Jason K K, Chang C C, Chang T Y. Myeloid-Acyl-CoA:Cholesterol Acyltransferase 1 deficiency reduces lesion macrophage content and suppresses atherosclerosis progression. Journal of Biological Chemistry, 2016, 291(12): 6232-6244.
Huang L H, Elvinton A, Randolph G. The role of the lymphatic system in cholesterol transport. Fortier in Pharmacology, 2015, 6:182.
Huang L H, Nishi K, Li S, Ho T, Dong R H, Chang C C, Chang T Y. Acyl-Coenzyme A: cholesterol acyltransferase 1: significance of single nucleotide polymorphism at residue 526 and role of proline 347 near the fifth transmembrane domain. FEBS J., 2014, 281(7): 1773-1783.
Huang L H, Gui J G, Artinger E, Craig R, Berwin B L, Ernst P A, Chang C C, Chang T Y. Acat1 gene ablation in mice increases hematopoietic progenitor cell proliferation in bone marrow and causes leukocytosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 2013, 33(9): 2081-2087.
申请专利
Chang, T. Y., Chang, C. C., Huang, L. H., Melton, E., Sohn, P.. Method for selectively inhibiting ACAT1 in the treatment of obesity, metabolic syndrome, and atherosclerosis. Jan. 2, 2018. Application number: **.
Chang, T. Y., Chang, C. C., Huang, L. H.. Methods for treating immunosuppression. Jun. 19, 2014. Application number: **.